grant
Investigating the Regulatory Roles of Histone Chaperones in Cellular Plasticity
Organization UNIVERSITY OF CALIFORNIA RIVERSIDELocation RIVERSIDE, UNITED STATESPosted 1 Aug 2023Deadline 31 Jul 2028
NIHUS FederalResearch GrantFY2025Basal Transcription FactorBasal transcription factor genesBindingBiochemicalCell BodyCell Fate ControlCell Fate RegulationCell Growth in NumberCell MultiplicationCell ProliferationCell ReprogrammingCellsCellular ProliferationChaperoneChromatinComplexDNADNA RecombinationDNA ReplicationDNA SynthesisDNA biosynthesisDeoxyribonucleic AcidDevelopmentDifferentiated GeneDiseaseDisorderElementsEnhancersGene Down-RegulationGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGenetic RecombinationGenetic TranscriptionGenomeGoalsHealthHeterochromatinHistonesLinkMaintenanceMolecularMolecular ChaperonesMolecular InteractionNucleosomesPathway interactionsPlayPost-Transcriptional Gene SilencingProcessProgenitor CellsProteinsRNA ExpressionRNA InterferenceRNA SilencingRNAiRecombinationRegulationResearchResearch ProposalsRoleSequence-Specific Posttranscriptional Gene SilencingSiteSpecific qualifier valueSpecifiedStructure-Activity RelationshipTranscriptionTranscription Factor Proto-OncogeneTranscription RepressionTranscription factor genesVariantVariationWorkcellular reprogrammingchemical structure functionchromatin assembly factor 1chromatin assembly factor Idesigndesigningdevelopmentalepigenomegene repressionmultiomicsmultiple omicsnew drug treatmentsnew drugsnew pharmacological therapeuticnew technologynew therapeuticsnew therapynext generation therapeuticsnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel technologiesnovel therapeuticsnovel therapypanomicspathwaypreventpreventingpromoterpromotorrepairrepairedsocial rolestemstem cellsstructural determinantsstructural factorsstructure function relationshiptranscription factor
Description preview
PROJECT SUMMARY
Histone chaperones are functionally and structurally diverse proteins. They play a central role in chromatin
organization and maintenance by binding to histones and facilitating nucleosome assembly during DNA
replication, transcription, recombination and repair processes. Moreover, some histone chaperones evolved
additional…
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