grant
Investigating the Pathogenic Role of Tubulin Post-translational Modifications in CIPN
Organization COLUMBIA UNIVERSITY HEALTH SCIENCESLocation NEW YORK, UNITED STATESPosted 1 Sept 2024Deadline 31 Aug 2029
NIHUS FederalResearch GrantFY202520S Catalytic Proteasome20S Core Proteasome20S Proteasome20S Proteosome21+ years old5-FU5-Fluracil5FUAblationAbscissionAcuteAdultAdult HumanAdverse effectsAffectAfferent NeuronsAgonistAlkylating AgentsAlkylatorsAnti-Cancer AgentsAnticonvulsant AgentAnticonvulsant DrugsAnticonvulsantsAnticonvulsive AgentsAnticonvulsive DrugsAntineoplastic AgentsAntineoplastic DrugsAntineoplasticsAnzataxAsotaxAxonBehaviorBehavioral AssayBiopsyBody TissuesBortezomibBristaxolCDDPCancer DrugCancer PatientCell Communication and SignalingCell SignalingCell modelCellular modelChemotherapy-induced peripheral neuropathyChronicCis-diammine-dichloroplatinumCis-diamminedichloridoplatinumCis-diamminedichloro Platinum (II)Cis-dichloroammine Platinum (II)Cis-platinous Diamine DichlorideCis-platinum IICis-platinum II Diamine DichlorideCisplatinCisplatinaCisplatinumCollaborationsCommunicationComplicationCysplatynaDataDevelopmentDichlorodiammineplatinumDiseaseDisorderDissociationDistalDoseDrug TherapyDrug usageDrugsDysfunctionEndoplasmic ReticulumEnzyme GeneEnzymesErgastoplasmExcisionExtirpationFiberFluoro UracilFluorouracilFluoruracilFluouracilFunctional disorderGenesHereditaryHumanHyperalgesiaHyperalgesic SensationsImageIn VitroIn vivo analysisInheritedInjuryIntracellular Communication and SignalingIntravenousInvestigatorsLeurocristineLoxP-flanked alleleMacropainMacroxyproteinaseMeasuresMechanicsMediatingMedicationMembrane PotentialsMiceMice MammalsMicro-tubuleMicrotubulesMitochondriaModelingModern ManModificationMolecularMotorMulticatalytic ProteinaseMurineMusNeoplastic Disease Chemotherapeutic AgentsNephrotoxicNerveNerve CellsNerve UnitNeural CellNeurocyteNeurologicNeurologicalNeuronsNeuropathyOpioid AnalgesicsOralOxygen ConsumptionPNS DiseasesPaclitaxelPaclitaxel (Taxol)PainPainfulPathogenesisPathogenicityPathologyPatientsPatternPeripheralPeripheral Nerve DiseasesPeripheral NervesPeripheral Nervous SystemPeripheral Nervous System DiseasesPeripheral Nervous System DisordersPeripheral NeuropathyPeyrone's ChloridePeyrone's SaltPharmaceutical PreparationsPharmacological TreatmentPharmacotherapyPhysiopathologyPlatinum DiamminodichloridePlayPost-Translational Modification Protein/Amino Acid BiochemistryPost-Translational ModificationsPost-Translational Protein ModificationPost-Translational Protein ProcessingPosttranslational ModificationsPosttranslational Protein ProcessingPraxelPre-Clinical ModelPreclinical ModelsProductionProsomeProteasomeProteasome Endopeptidase ComplexProteasome InhibitorProtein ModificationProteosomeProtocolProtocols documentationPublishingQuantitative EvaluationsRegulationRemovalResearch PersonnelResearchersResting PotentialsRoleSensory Nerve EndingsSensory NeuronsSensory impairmentSignal TransductionSignal Transduction SystemsSignalingSkinSurgical RemovalTRP channelTaxolTaxol ATaxol KonzentratTestingTherapeuticThermal HyperalgesiasTimeTissuesTransient receptor potential channelTransmembrane PotentialsTubulinTumor-Specific Treatment AgentsVinca Alkaloid CompoundVinca AlkaloidsVincristineVincrystineWorkadulthoodafferent nerveanti-cancer druganti-depressant agentanti-depressant drugsanti-depressantsanti-depressive agentsaxon damageaxon injuryaxonal damageaxonal degenerationaxonal injuryaxonopathybiological signal transductionchemotherapeutic agentchemotherapeutic compoundschemotherapeutic drugschemotherapeutic medicationschemotherapycis dichlorodiammineplatinumcis platinum compoundcis-Diaminedichloroplatinumcis-Diamminedichloroplatinumcis-Diamminedichloroplatinum(II)cis-Dichlorodiammineplatinum(II)cis-Platinumcomparativedegenerative axondevelopmentaldrug actiondrug induced hearing impairmentdrug induced hearing lossdrug interventiondrug treatmentdrug usedrug/agentfloxedfloxed allelehigh riskhyperalgiaimagingin vivoin vivo evaluationin vivo testinginhibitorinjuriesinsightkidney toxicitylentiviral-mediatedmechanicmechanicalmechanical allodyniamitochondrialmulticatalytic endopeptidase complexmultidisciplinarynephrotoxicitynerve damageneuronalneuropathicneuropathic painneurotoxicnovelopiate analgesiaopiate analgesicopiate pain medicationopiate pain relieveropioid analgesiaopioid anestheticopioid pain medicationopioid pain relieveropioid painkillerototoxicototoxicityoverexpressoverexpressionoxovincaleukoblastinepainful neuropathypathophysiologypharmaceutical interventionpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticspreventpreventingresectionsciatic nerveseizure drugseizure medicationsensory nervesocial rolespontaneous painsural nervetaxanetheoriesα Tubulin
Description preview
SUMMARY
Chemotherapy induced peripheral neuropathy (CIPN) is the most prevalent neurological complication of
oral or intravenous chemotherapy. Approximately 50–90% of patients under chemotherapy are affected by CIPN
and bear a high risk of chronicity (approx. 30–40%). Limited symptomatic relief is provided by opioid analgesics,
antidepressants,…
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