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Investigating the molecular and cellular mechanisms of virus-associated hepatocellular carcinoma
Organization ROCKEFELLER UNIVERSITYLocation NEW YORK, UNITED STATESPosted 1 Sept 2019Deadline 31 Mar 2026 ⚠️
NIHUS FederalResearch GrantFY2025ATAC sequencingATAC-seqATACseqAddressAdvanced CancerAdvanced Malignant NeoplasmAllelesAllelomorphsAntigen PresentationAntigen Presentation PathwayAntigen Processing and PresentationAntioncogene Protein p53Assay for Transposase-Accessible Chromatin using sequencingAutomobile DrivingBiologic PhenomenaBiological PhenomenaBiologyBypassCancer CauseCancer ControlCancer Control ScienceCancer EtiologyCancer PatientCancer TreatmentCancersCarcinoma CellCell AgingCell BodyCell CommunicationCell Cycle ArrestCell InteractionCell SenescenceCell Senescence InductionCell Surface ProteinsCell surfaceCell-to-Cell InteractionCellsCellular AgingCellular SenescenceCellular Tumor Antigen P53Cellular injuryCharacteristicsCuesCytotoxic cellDataDevelopmentDiseaseDisease OutbreaksDisorderEngineeringEnvironmentEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEpitheliumEvolutionExtrahepaticGeneticGenetic ScreeningGoalsHepatic CancerHepatic Neoplasm SecondaryHepatic NeoplasmsHepatic metastasisHepatocarcinomaHepatocellular CarcinomaHepatocellular cancerHepatomaHeterogeneityImmuneImmune EvasionImmune SurveillanceImmune mediated therapyImmune systemImmunesImmunityImmunocompetentImmunocompromisedImmunocompromised HostImmunocompromised PatientImmunodeficient MouseImmunologic SurveillanceImmunologically Directed TherapyImmunologyImmunomodulationImmunosuppressed HostImmunosurveillanceImmunotherapyImpairmentInnate ImmunityK lymphocyteKI miceKnock-in MouseLabelLaboratoriesLesionLigandsLinkLiver Cells CarcinomaLiver neoplasmsLiver secondariesLiver secondary cancerLungLung Respiratory SystemMalignant CellMalignant Epithelial CellMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMalignant NeoplasmsMalignant TumorMalignant neoplasm of liverMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMediatingMetastasisMetastasis to the LungMetastasizeMetastatic LesionMetastatic MassMetastatic NeoplasmMetastatic Neoplasm to the LiverMetastatic Neoplasm to the LungMetastatic TumorMetastatic Tumor to the LiverMetastatic Tumor to the LungMetastatic malignant neoplasm to liverMiceMice MammalsModelingMolecularMolecular Dynamics SimulationMouse StrainsMurineMusNK CellsNative ImmunityNatural ImmunityNatural Killer CellsNeoplasm MetastasisNon-Specific ImmunityNonspecific ImmunityOncogenesisOncoprotein p53OutbreaksP53Pathway interactionsPatientsPhasePhosphoprotein P53Phosphoprotein pp53PlayPopulation HeterogeneityPostdocPostdoctoral FellowPredispositionPrimary carcinoma of the liver cellsProcessProliferatingProtein TP53ProteomeR-Series Research ProjectsR01 MechanismR01 ProgramRNA SeqRNA sequencingRNAseqRegulatory PathwayReplicative SenescenceResearchResearch AssociateResearch GrantsResearch Project GrantsResearch ProjectsRoleSecondary NeoplasmSecondary TumorShapesSideSiteSusceptibilityTP53TP53 geneTRP53TechnologyTumor CellTumor ImmunityTumor PromotionTumor Protein p53Tumor Protein p53 GeneValidationVirusWorkadaptive immunityanti-cancer therapyanti-tumor immune responseanti-tumor immunityantitumor immunityassay for transposase accessible chromatin followed by sequencingassay for transposase accessible chromatin seqassay for transposase accessible chromatin sequencingassay for transposase-accessible chromatin with sequencingcancer cellcancer immunitycancer metastasiscancer progressioncancer therapycancer-directed therapycell damagecell injurycellular aging inductioncellular damagecellular senescence inductiondamage to cellsdevelopmentaldiverse populationsdrivingdynamical evolutionepigeneticallyexhaustionhepatic neoplasiahepatic neoplasmhepatic tumorheterogeneous populationimmune clearanceimmune competentimmune eliminationimmune evasiveimmune microenvironmentimmune modulationimmune regulationimmune senescenceimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based therapiesimmune-based treatmentsimmuno therapyimmunologic reactivity controlimmunomodulatoryimmunoregulationimmunoregulatoryimmunosenescenceimmunosuppressed patientimmunosuppressive microenvironmentimmunosuppressive tumor microenvironmentin vivoinjury to cellsinsightknockin miceliver cancerliver carcinomaliver malignancyliver metastasesliver tumorlung metastasismalignancymalignant liver neoplasm, specified as secondarymalignant liver tumormetastasis in the livermetastasis to the livermetastasize to the livermetastasize to the lungmetastatic cancer to livermetastatic livermetastatic liver neoplasmmolecular dynamicsmortalitymouse modelmurine modelneoplasm progressionneoplasm/cancerneoplastic cellneoplastic progressionnew approachesnovelnovel approachesnovel strategiesnovel strategyp53 Antigenp53 Genesp53 Tumor Suppressorpathwaypharmacologicpopulation diversitypost-docpost-doctoralpost-doctoral traineeprogramsprotein p53pulmonary metastasisreplicative agingresearch associatesrestorationscRNA sequencingscRNA-seqsecondary liver malignancysecondary malignant liver neoplasmsenescencesenescence inductionsenescentsenescent cellsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial roletooltranscriptome sequencingtranscriptomic sequencingtumortumor cell metastasistumor immune microenvironmenttumor initiationtumor progressiontumor-immune system interactionstumorigenesisvalidations
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PROJECT SUMMARY/ABSTRACT
Cancer development accompanies with the dynamic evolution of immunity, a well-known process termed as
immunoediting. However, the underlying mechanisms of the transition between each phase, from immune
surveillance to final escape, still remain a lot to discover. This proposal aims to study…
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