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Investigating the mechanism of decision-making in the mitochondrial Protease YME1
Organization SCRIPPS RESEARCH INSTITUTE, THELocation LA JOLLA, UNITED STATESPosted 16 Jan 2024Deadline 15 Jan 2026 ⚠️
NIHUS FederalResearch GrantFY2025AD dementiaAICDAAICDA proteinAID geneAID proteinATP-Dependent ProteasesATP-Requiring ProteaseAdenosine Triphosphate-Dependent Proteolytic SystemAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimers DementiaApoptosisApoptosis PathwayAssayAutomobile DrivingAutoregulationBindingBioassayBiochemicalBiological AssayCDA2 proteinCancersCardiovascular DiseasesCatalytic CoreCatalytic DomainCatalytic RegionCatalytic SiteCatalytic SubunitCell BodyCellsCellular StressCellular Stress ResponseCellular biologyChaperoneCommunicationComplexConsensus SequenceConserved SequenceCryo-electron MicroscopyCryoelectron MicroscopyDecision MakingDegenerative Neurologic DisordersElectron CryomicroscopyEnzyme GeneEnzymesEsteroproteasesEventEye diseasesFluorescenceGeneticGenetics-MutagenesisHealthHomeostasisHumanImpairmentInner mitochondrial membraneInvestigationIsoformsMalignant NeoplasmsMalignant TumorMediatingMetabolicMetabolic DiseasesMetabolic DisorderMitochondriaMitochondrial ProteinsModalityModelingModern ManMolecularMolecular ChaperonesMolecular Dynamics SimulationMolecular InteractionMolecular Modeling Nucleic Acid BiochemistryMolecular Modeling Protein/Amino Acid BiochemistryMolecular ModelsMorphologyMutagenesisMutagenesis Molecular BiologyN-terminalNH2-terminalNervous System Degenerative DiseasesNeural Degenerative DiseasesNeural degenerative DisordersNeurodegenerative DiseasesNeurodegenerative DisordersNeurologic Degenerative ConditionsOptic AtrophyOptic atrophy 1OrganellesOutcome StudyOxidative PhosphorylationOxidative Phosphorylation PathwayParalysis AgitansParkinsonParkinson DiseasePathologicPeptidasesPeptide HydrolasesPeptidesPhysiologicPhysiologicalPhysiological HomeostasisPlayPrimary ParkinsonismPrimary Senile Degenerative DementiaProcessProgrammed Cell DeathProtease GeneProteasesProtein IsoformsProteinasesProteinsProteolytic ClippingProteolytic EnzymesProteolytic ProcessingProteolytic RegulationProteomeQuality ControlRegulation of ProteolysisRoleSiteStimulusStressStructureTailTestingThesaurismosisToxic effectToxicitiesWorkYeastsactivation-induced cytidine deaminaseactivation-induced deaminaseage associatedage correlatedage dependentage linkedage relatedage specificbasebasescardiovascular disordercell biologycell stresscryo-EMcryoEMcryogenic electron microscopydegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdrivingeye disorderfunctional plasticityhuman diseaseinsightinsoluble aggregatemalignancymetabolism disordermigrationmitochondrialmitochondrial dysfunctionmolecular dynamicsmolecular modelingneoplasm/cancerneurodegenerative illnessocular diseaseocular disorderophthalmopathypreferencepreservationpreventpreventingprimary degenerative dementiaprotein aggregateprotein aggregationprotein functionprotein homeostasisproteostasisresponsesenile dementia of the Alzheimer typesocial role
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Description preview
PROJECT SUMMARY
YME1 is an ATP-dependent protease located in the inner mitochondrial membrane, and plays a central role in
executing the functional activities of the mitochondrial protein quality control network. Preserving homeostasis
within the mitochondria is critical to maintaining cellular health and preventing a wide range of human diseases…
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