grant
Investigating the influence of human milk oligosaccharides on bacterial-immune dynamics in the gravid vaginal tract
Organization BAYLOR COLLEGE OF MEDICINELocation HOUSTON, UNITED STATESPosted 1 Aug 2025Deadline 31 Jul 2028
NIHUS FederalResearch GrantFY2025(TNF)-αA vaginaeA. vaginaeAdhesionsAerobicAlimentary CanalAnimal ModelAnimal Models and Related StudiesAnti-InflammatoriesAnti-Inflammatory AgentsAnti-inflammatoryAntibiotic AgentsAntibiotic DrugsAntibioticsAssayAtopobium vaginaeAutoregulationBacteriaBacterial Antibiotic ResistanceBacterial VaginitisBacterial VaginosisBifidobacteriumBioassayBiologic ModelsBiological AssayBiological ModelsBioreactorsBloodBlood Reticuloendothelial SystemBlood SerumBreast MilkBreast fed infantBreastfed infantBreastmilkCachectinCell Communication and SignalingCell SignalingCirculationCommunitiesComplexDataDigestive TractDiseaseDisorderEpithelial CellsEpitheliumFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryGI TractGU InfectionGastrointestinal TractGastrointestinal tract structureGene TranscriptionGeneralized GrowthGenetic TranscriptionGenitourinary System InfectionGenitourinary infectionGestationGlycansGravidGrowthHealthHealth BenefitHealth StatusHomeostasisHumanHuman MicrobiomeHuman MilkHuman Mother's MilkImmuneImmune responseImmunesImmunologyIn VitroIndividualInfantInfectionInflammationInflammatoryIntracellular Communication and SignalingInvadedLactationLactobacillusLevel of HealthMacrophage-Derived TNFMammary Gland MilkMediatingMedicineMentorshipMethodsMiceMice MammalsMicrobeMiscellaneous AntibioticModel SystemModern ManMonocyte-Derived TNFMother's MilkMothersMurineMusNeonatalNonspecific VaginitisOrganoidsOutcomePathway interactionsPhysiological HomeostasisPlayPolysaccharidesPregnancyPregnancy OutcomePremature BirthPrematurely deliveringPreterm BirthProductionRNA ExpressionRiskRisk FactorsRoleS agalactiaeS. agalactiaeSerumSignal TransductionSignal Transduction SystemsSignalingSolidStreptococcus Group BStreptococcus agalactiaeStructureSupplementationSwabTNFTNF ATNF AlphaTNF geneTNF-αTNFATNFαTestingTherapeuticTissue GrowthTrainingTranscriptionTransmissionTumor Necrosis FactorTumor Necrosis Factor-alphaUrineVaginaVaginitisWomanWorkadverse consequenceadverse outcomealimentary tractanalyze microbiomeantibiotic resistant bacteriabacterial antibiotic resistantbacterial communitybacterial resistance to antibioticbeneficial florabeneficial microbesbeneficial microflorabeneficial microorganismbiological signal transductionbreast feeding infantbreastfeeding infantcollegecollegiatecommunity microbescomparative genomicscytokinedigestive canalexperimentexperimental researchexperimental studyexperimentsfeedingflow cytophotometrygenitourinary tracthealth levelhost microbe associationhost microbe relationshiphost responsehost-microbe interactionshost-microbial interactionshost-microorganism interactionshuman milk oligosaccharideshuman-associated microbiomeimmune system responseimmunoresponsein uteroin vitro activityin vivoinfant outcomeinfectious disease of genitourinary systeminsightintestinal barrierintestinal mucosal barrierlactatinglactationalmaternal milkmaternal outcomemembermicrobe communitymicrobialmicrobial communitymicrobial compositionmicrobial consortiamicrobial floramicrobiomemicrobiome analysismicrobioreactormicrobiotamicrofloramicroorganism communitymodel of animalmother outcomemouse modelmultispecies consortiamurine modelneonatal outcomeneonatenew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnon-specific vaginitisnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyontogenypathobiontpathogenpathogenic E colipathogenic E. colipathogenic Escherichia colipathwaypolymicrobial communityprebioticspregnantpremature childbirthpremature deliverypreterm deliveryresponserisk mitigationsocial roletransmission processurogenital infectionurogenital tractvaginal biomevaginal floravaginal microbial communityvaginal microbiomevaginal microbiotavaginal microfloravaginal mucosa
Description preview
Project Summary
The vaginal microbiota during pregnancy is an important reservoir for infant microbial seeding, but factors that
impact the composition are complex and largely unknown. Vaginal presence of neonatal pathogens, like group
B Streptococcus and extraintestinal pathogenic Escherichia coli, are associated with increased risk for adverse…
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