grant
Investigating the impact of a diabetic urinary environment on group B Streptococcus virulence and host response.
Organization BAYLOR COLLEGE OF MEDICINELocation HOUSTON, UNITED STATESPosted 1 Mar 2026Deadline 28 Feb 2029
NIHUS FederalResearch GrantFY202621+ years oldABC Transport ProteinABC Transporter ProteinABC TransportersATP-Binding Cassette TransportersActive OxygenAdultAdult HumanAdult-Onset Diabetes MellitusAffectAldehydesAminobenzyl PenicillinAminobenzylpenicillinAmpicillinAntibiotic AgentsAntibiotic DrugsAntibiotic ResistanceAntibioticsAutomobile DrivingBacteriaBacterial GenesBiologic ModelsBiological ModelsBladderBladder Urinary SystemBlood NeutrophilBlood Polymorphonuclear NeutrophilCarbohydratesCarbonCell BodyCell FunctionCell PhysiologyCell ProcessCellsCellular FunctionCellular Immune FunctionCellular PhysiologyCellular ProcessCiprofloxacinComplexD-GlucoseDataDevelopmentDextroseDiabetes MellitusDiabetic mouseDiseaseDisorderE coliE. coliEnergy-Generating ResourcesEnvironmentEpithelial CellsEpitheliumEscherichia coliFructoseGene TranscriptionGeneralized GrowthGenesGenetic TranscriptionGenitourinaryGenitourinary systemGlucoseGlycosuriaGroups at riskGrowthHormone imbalanceHost DefenseHost FactorHost Factor ProteinHumanHyperglycemiaHypoglycemiaImmuneImmune responseImmunesImmunologyIn VitroIncidenceIndividualInfectionIntegration Host FactorsIntermediary MetabolismInterventionInvadedInvestigatorsK pneumoniaeK. pneumoniaeKetosis-Resistant Diabetes MellitusKlebsiella pneumoniaeLevuloseLinkLiteratureMarrow NeutrophilMaturity-Onset Diabetes MellitusMedicineMentorshipMetabolicMetabolic DiseasesMetabolic DisorderMetabolic ProcessesMetabolismMiscellaneous AntibioticModel SystemModelingModern ManMucosaMucosal TissueMucous MembraneNIDDMNeutrophilic GranulocyteNeutrophilic LeukocyteNon-Insulin Dependent DiabetesNon-Insulin-Dependent Diabetes MellitusNoninsulin Dependent DiabetesNoninsulin Dependent Diabetes MellitusNutrientOrganoidsOxidative StressOxygen RadicalsPathogenesisPathogenicity FactorsPathway interactionsPatientsPeople at riskPersonsPersons at riskPlayPolymorphonuclear CellPolymorphonuclear LeukocytesPolymorphonuclear NeutrophilsPopulationPopulations at RiskPre-DMPrediabetesPrediabetes syndromePrediabetic StatePredispositionPregnant WomenPreventative measurePreventive measurePro-OxidantsPyelonephritisRNA ExpressionRNA SeqRNA sequencingRNAseqReactive Oxygen SpeciesRecurrenceRecurrentRegulationResearchResearch PersonnelResearchersResistanceResistance to antibioticsResistant to antibioticsRespirationRisk ReductionRoleS agalactiaeS. agalactiaeSamplingShapesSlow-Onset Diabetes MellitusSoft Tissue InfectionsSourceStable Diabetes MellitusStreptococcal InfectionsStreptococcus Group BStreptococcus agalactiaeStreptococcus infectionSubcellular ProcessSusceptibilityT2 DMT2DT2DMTestingThesaurismosisTissue GrowthTrainingTranscriptionTropismType 2 Diabetes MellitusType 2 diabetesType II Diabetes MellitusType II diabetesUrinary tractUrinary tract infectionUrinary tract infectious diseaseUrineUrogenitalUrogenital SystemVirulenceVirulence FactorsVirulentWorkadult onset diabetesadulthoodalternative treatmentantibiotic drug resistanceantibiotic resistantclinical relevanceclinically relevantcollegecollegiatedevelopmentaldiabetesdiabetes mouse modeldiabeticdiabetic patientdifferential expressiondifferentially expresseddrivingenergy efficiencyenergy sourceexpectant motherexpectant womenexpecting motherexpecting womenexperienceexperimentexperimental researchexperimental studyexperimentsfitnesshigh risk grouphigh risk individualhigh risk peoplehigh risk populationhormonal imbalancehost responsehyperglycemichypoglycemichypoglycemic episodesimmune functionimmune system responseimmunoresponseimprovedin vivoindividuals who are pregnantinfected neonateinfected newborninsightinterestketosis resistant diabeteskidney infectionmaturity onset diabetesmetabolism disordermicrobialmouse modelmurine modelmutantneonatal infectionneonateneutrophilnewborn infectionnon-diabeticnondiabeticnovelontogenypathogenpathwaypeople who are pregnantpre-diabetespre-diabeticprediabeticpregnant femalespregnant motherspregnant peoplepregnant populationspreventpreventingreduce riskreduce risksreduce that riskreduce the riskreduce these risksreduces riskreduces the riskreducing riskreducing the riskresistantrespiratory mechanismresponserisk-reducingsocial rolesugarthose who are pregnanttissue culturetranscriptional differencestranscriptome sequencingtranscriptomic sequencingtreatment strategytype 2 DMtype II DMtype two diabetesurinaryurinary bladderurinary infectionurinary sepsisurosepsiswomen who are pregnant
Description preview
PROJECT SUMMARY/ABSTRACT
Group B Streptococcus (GBS) is commonly associated with neonatal infections and can also cause a
variety of soft tissue infections, including urinary tract infections (UTI) in non-pregnant adults. However, patients
suffering from type 2 diabetes have a significantly higher incidence of GBS UTIs. Additionally, diabetics…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click