grant
Investigating the function of a ciliary protein in neural development
Organization UNIVERSITY OF WASHINGTONLocation SEATTLE, UNITED STATESPosted 16 Jun 2025Deadline 15 May 2028
NIHUS FederalResearch GrantFY20254-Aminobutanoic Acid4-Aminobutyric Acid4-amino-butanoic acidAffectAfferent NeuronsAffinity ChromatographyAminalonAminaloneBehaviorBiochemicalBiochemistryBiological ChemistryBiological FunctionBiological ProcessBody TissuesBrainBrain Nervous SystemC elegansC. elegansC.elegansCRISPRCRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas systemCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCaenorhabditis elegansCas nuclease technologyCell BodyCell Communication and SignalingCell FunctionCell PhysiologyCell ProcessCell SignalingCellsCellular FunctionCellular PhysiologyCellular ProcessCiliaClinical geneticsClustered Regularly Interspaced Short Palindromic RepeatsClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyComplexDataDegenerative Neurologic DisordersDendritesDevelopmentDiseaseDisorderDrosophilaDrosophila genusDysfunctionEncephalonEngineeringFoundationsFunctional disorderGABAGene variantGeneticGenetic studyGoalsGrowth and DevelopmentGrowth and Development functionHumanIntracellular Communication and SignalingInvestigatorsKnowledgeMediatingMedical GeneticsModern ManMolecularMotor CellMotor NeuronsNerve CellsNerve UnitNervous SystemNervous System Degenerative DiseasesNervous System DiseasesNervous System DisorderNeural CellNeural Degenerative DiseasesNeural DevelopmentNeural degenerative DisordersNeurobiologyNeurocyteNeurodegenerative DiseasesNeurodegenerative DisordersNeurodevelopmental DisorderNeurologic Body SystemNeurologic Degenerative ConditionsNeurologic DisordersNeurologic Organ SystemNeurological Development DisorderNeurological DisordersNeuronsOrganOrthologOrthologous GeneOutcomePathologicPathway interactionsPatientsPhotoreceptor CellPhotoreceptorsPhotosensitive CellPhysiologicPhysiologicalPhysiopathologyProcessProteinsProteomicsResearchResearch PersonnelResearchersRetinaRodentRodentiaRodents MammalsRoleScientistSensorySensory NeuronsShapesSignal TransductionSignal Transduction SystemsSignalingSubcellular ProcessSynapsesSynapticSyndromeSystemTechniquesTestingTherapeutic InterventionTimeTissuesTrainingTransgenesTransgenic OrganismsTransmissionUbiquitin Ligase Component GeneUbiquitin Ligase GeneVisual ReceptorVisualizationWorkaffinity purificationallelic variantbiological signal transductionciliopathydegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdevelopmentalexperimentexperimental researchexperimental studyexperimentsfruit flygain of functiongamma-Aminobutyric Acidgenetic approachgenetic strategygenetic variantgenomic varianthuman diseasein vivointercellular connectionintervention therapylater in lifelater lifemodel organismmotoneuronnervous system developmentneurobiologicalneurodegenerative illnessneurodevelopmentneurodevelopmental diseaseneurological diseaseneuron developmentneuronalneuronal developmentnovelpathophysiologypathwaypostsynapticpresynapticskillssocial rolesuperresolution microscopysynapsesynapse formationsynaptogenesistime usetransgenetransgenictransmission processubiquitin ligaseγ-Aminobutyric Acid
Description preview
PROJECT SUMMARY/ABSTRACT
Synapses serve as vital intercellular connections facilitating rapid and accurate transmission of information
between neurons. Successful nervous system development is dependent on proper synapse formation, an
intricate and highly coordinated process regulated by complex cellular and molecular mechanisms. Elucidating
the…
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