grant
Investigating the Ferrostatic Role of Adipose Tissue Macrophages
Organization MASSACHUSETTS INSTITUTE OF TECHNOLOGYLocation CAMBRIDGE, UNITED STATESPosted 1 Jul 2025Deadline 30 Jun 2028
NIHUS FederalResearch GrantFY2025AblationActive OxygenAdipocytesAdipose CellAdipose tissueAdrenergic ReceptorAdrenoceptorsAdult-Onset Diabetes MellitusAnemiaAntigen-Presenting CellsAutoregulationBiochemistryBiologicalBiological ChemistryBiologyBlood CirculationBlood DiseasesBlood SerumBloodstreamBody TissuesCD71CancersCarrier ProteinsCell BodyCell Communication and SignalingCell FunctionCell PhysiologyCell ProcessCell SignalingCellsCellular FunctionCellular PhysiologyCellular ProcessDataDevelopment and ResearchDiseaseDisorderDysfunctionElementsEnvironmentEpinephrine ReceptorsEquilibriumFHC geneFHC proteinFTH geneFTH proteinFTH1FTH1 geneFTHL6Fat CellsFatty TissueFe deficiencyFe elementFe isotopeFe overloadFerritinFerritin Heavy Chain 1Functional disorderGene Expression MonitoringGene Expression Pattern AnalysisGene Expression ProfilingGenesGeneticGlucose tolerance testGoalsHematologic DiseasesHematological DiseaseHematological DisorderHomeostasisHost DefenseHousingICP-MSIPGTTImmune systemImmunityImmunologyIn TransferrinIndividualInductively Coupled Plasma Mass SpectrometryIndustrializationInjectionsInnate ImmunityIntermediary MetabolismIntracellular Communication and SignalingInvestigationIronIron IsotopesIron OverloadKetosis-Resistant Diabetes MellitusKnowledgeLightLinkLipocytesLipolysisLiteratureMacrophageMaintenanceMalignant NeoplasmsMalignant TumorMature LipocyteMature fat cellMaturity-Onset Diabetes MellitusMeasuresMediatingMetabolic ProcessesMetabolismMiceMice MammalsMicronutrientsMitochondriaModelingMolecularMonitorMurineMusMyelogenousMyeloidMφNIDDMNative ImmunityNatural ImmunityNervous System DiseasesNervous System DisorderNeurologic DisordersNeurological DisordersNon-Insulin Dependent DiabetesNon-Insulin-Dependent Diabetes MellitusNon-Specific ImmunityNoninsulin Dependent DiabetesNoninsulin Dependent Diabetes MellitusNonspecific ImmunityOrganOrgan ModelOrganismOxygen RadicalsPathway interactionsPhotoradiationPhysiologicPhysiologicalPhysiological HomeostasisPhysiologyPhysiopathologyPopulationPreparationPro-OxidantsProcessR & DR&DReactive Oxygen SpeciesRegulationRoleRouteSensorySerumSiderophilinSignal TransductionSignal Transduction SystemsSignalingSlow-Onset Diabetes MellitusSpecificityStable Diabetes MellitusStarvationSubcellular ProcessSupporting CellT2 DMT2DT2DMTFR geneTFR proteinTFR1TFRCTFRC geneTRFRTechnologyTestingTissuesTrainingTranscript Expression AnalysesTranscript Expression AnalysisTransferrinTransferrin ReceptorTransferrin Receptor 1Transport Protein GeneTransport ProteinsTransporter ProteinType 2 Diabetes MellitusType 2 diabetesType II Diabetes MellitusType II diabetesValidationWhole OrganismWorkaccessory celladenoreceptoradiposeadult onset diabetesanalyze gene expressionbalancebalance functionbiologicbiological signal transductionblood disordercareercell typechronic inflammatory diseasedevelop therapydifferential expressiondifferentially expressedexperimentexperimental researchexperimental studyexperimentsferroportinferroportin1 proteinfluorophoregene expression analysisgene expression assayglucose metabolisminsightinsulin sensitivity testinsulin tolerance testinsulin-induced hypoglycemia testintervention developmentintraperitoneal glucose tolerance testiron deficiencyketosis resistant diabetesliving systemmalignancymaturity onset diabetesmetal transporting protein 1mitochondrialmouse modelmurine modelneoplasm/cancerneurological diseasenovelpathophysiologypathwaypharmacologicpreparationsresearch and developmentresponseskillssocial rolesolute carrier family 40 (iron-regulated transporter), member 1therapy developmenttranscriptional differencestranscriptional profilingtranscriptomicstreatment developmenttype 2 DMtype II DMtype two diabetesuptakevalidationswhite adipose tissueyellow adipose tissue
Description preview
PROJECT SUMMARY
Iron is a micronutrient that is essential for nearly every living organism, and maintaining its homeostasis
therefore represents a crucial biological problem across all scales: from cells, to tissues, to the whole organism.
We propose that central regulation of local iron supply in the adipose tissue is controlled by VAMs…
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