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Investigating the Effects of Spinal Cord Injury and Rehabilitative Training on Corticospinal Circuits Controlling Contextual Opioid Analgesic Tolerance
Organization YALE UNIVERSITYLocation NEW HAVEN, UNITED STATESPosted 1 Sept 2025Deadline 30 Nov 2025 ⚠️
NIHUS FederalResearch GrantFY2025Academic skillsAcute PainAcutely painfulAddressAffectAnalgesia TestsAnalgesic AgentsAnalgesic DrugsAnalgesic PreparationAnalgesicsAnodynesAnteriorAntinociceptive AgentsAntinociceptive DrugsApplications GrantsAxonBehaviorBehavioralBilateralBiologic FactorBiologicalBiological FactorsBrainBrain Nervous SystemBrain regionBruiseChestClinicContusionsDataDevelopmentDrugsEffectivenessEncephalonEnvironmentEnvironmental FactorEnvironmental Risk FactorFemaleFiberForelimbFoundationsGeneticGoalsGrant ProposalsHindlimbHistologyHomeHyperalgesiaHyperalgesic SensationsImmediate-Early GenesImmunohistochemistryImmunohistochemistry Cell/TissueImmunohistochemistry Staining MethodImpairmentIndividualInjuryInvestigatorsKnowledgeLabelLaboratory ResearchLearningLesionLifeLinkLocationLumbar Portion of Spinal CordLumbar Spinal CordLumbar spinal cord structureMeasuresMechanicsMediatingMedical RehabilitationMedicationMedulla SpinalisMethodsMiceMice MammalsModelingMonitorMurineMusNerve CellsNerve UnitNeural CellNeurocyteNeuronsNociceptionNociception TestsOpiatesOpioidOpioid AnalgesicsOpticsOverdosePainPain AssessmentPain ControlPain MeasurementPain TherapyPain managementPain measurePainfulPathway interactionsPatientsPharmaceutical PreparationsPharmacologyPhasePhotometryPlayPopulationPositionPositioning AttributeProceduresProxyRefractoryRehabilitationRehabilitation therapyReportingResearchResearch PersonnelResearchersResistanceRiskRodentRodent ModelRodentiaRodents MammalsRoleSCI PatientsScientific Advances and AccomplishmentsSpinalSpinal CordSpinal Cord TraumaSpinal TraumaSpinal cord injuredSpinal cord injurySpinal cord injury patientsTechnical ExpertiseTechniquesTestingThoraceThoracicThoraxTracerTrainingTransmissionTraumatic MyelopathyViralWorkactivity markeraddictionaddictive disorderbehavioral pharmacologybiologiccareerchronic neuropathic painchronic painchronic pain controlchronic pain interventionchronic pain managementchronic pain therapychronic pain treatmentcingulate cortexclinical relevanceclinically relevantconditioningconventional therapyconventional treatmentdensitydevelopmentaldrug/agentenvironmental riskexperiencegenetic approachgenetic strategyhomeshyperalgiaimprovedin vivoinjuriesinsightlicit opioidmalemechanicmechanicalmotor rehabmotor rehabilitationmotor rehabilitative therapyneuralneuronalneuronal circuitneuronal circuitryneuropathic painnociceptivenon-medical opioid usenonmedical opioid usenovelopiate analgesiaopiate analgesicopiate consumptionopiate drug useopiate intakeopiate medicationopiate misuseopiate overdoseopiate pain medicationopiate pain relieveropiate related overdoseopiate toleranceopiate useopiate use disorderopioid analgesiaopioid anestheticopioid consumptionopioid drug overdoseopioid drug useopioid habituationopioid induced overdoseopioid intakeopioid intoxicationopioid medicationopioid medication overdoseopioid misuseopioid overdoseopioid pain medicationopioid pain relieveropioid painkilleropioid poisoningopioid related overdoseopioid toleranceopioid toxicityopioid useopioid use disorderopticaloverdose deathoverdose fatalitiesoverdose riskpain assaypain interventionpain killerpain medicationpain modelpain outcomepain relieverpain treatmentpain-related outcomepainful neuropathypainkillerpathwaypharmacobehavioralpost-traumaposttraumaprescribed opiateprescribed opioidprescription opiateprescription opioidprofessorrehab therapyrehabilitativerehabilitative therapyresistantresponsescientific accomplishmentsscientific advancessham surgeryskillssocial roletechnical skillstolerance to opiatestransmission processtreat chronic pain♀♂
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Description preview
PROJECT SUMMARY: Pain remains a major issue after spinal cord injury (SCI), with over 60% experiencing
chronic pain and one-third suffering from intense, opioid-resistant pain. This leads to higher opioid use,
increasing risks of tolerance and misuse, underscoring the need to understand the biological factors involved. As
individuals with SCI…
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