grant
Investigating the effects of Doxycycline (DoxyPEP) on intra-rectal HIV acquisition
Organization NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASESLocation UNITED STATES
NIHUS FederalResearch GrantFY2025AIDS VirusAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusAddressAlimentary CanalAntibiotic AgentsAntibiotic DrugsAntibioticsAsianBacterial InfectionsBody TissuesChronic DiseaseChronic IllnessDataDevelopmentDietDigestive TractDisease OutcomeDoseDoxycyclineEpitheliumGI TractGI microbiomeGastrointestinal TractGastrointestinal tract structureHIVHumanHuman Immunodeficiency VirusesImmunityIndividualInfectionInflammationIntestinalIntestinesLAV-HTLV-IIILongitudinal StudiesLymphadenopathy-Associated VirusMacacaMacaqueMaintenanceMiscellaneous AntibioticModern ManMucosaMucosal TissueMucous MembranePharmaceutical AgentPharmaceuticalsPharmacologic SubstancePharmacological SubstancePredispositionPreventionProphylactic treatmentProphylaxisRectumRiskSexual TransmissionSexually Transmitted DiseasesSexually Transmitted DisorderSexually Transmitted InfectionSusceptibilityTissuesVancomycinVenereal DiseasesVenereal DisordersVenereal InfectionsVibramycinViralVirusVirus-HIValimentary tractalpha-6-Deoxyoxytetracyclineanti-microbialantimicrobialbacteria infectionbacterial diseasebowelbowel inflammationchronic disordercohortdevelopmentaldietsdigestive canaldigestive tract microbiomeenteric microbiomegastrointestinal microbiomegut inflammationgut microbiomegut-associated microbiomeinflamed bowelinflamed gutinflamed intestineintestinal biomeintestinal inflammationintestinal microbiomelong-term studylongitudinal outcome studiesmetabolomemetabonomemicrobiomemicrobiome community compositionmicrobiome compositionmicrobiome species compositionmicrobiome structurepathogen exposurepathogenic viruspharmaceuticalpoor health outcomepreventpreventingreduced health outcomesexually acquired infectionsexually transmittedtreatment guidelinesviral pathogenvirus pathogenworse health outcome
Description preview
Bacterial, sexually transmitted infections are associated with poor health outcomes and increased risk of secondary viral acquisition. To curb these bacterial infections, clinicians have begun to prescribe high doses of the antibiotic doxycycline as post-exposure prophylaxis. Though effective at preventing bacterial infections, it is unknown…
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