grant
Investigating the effect of dysregulated vitamin D metabolism on kidney development following preterm birth
Organization UNIVERSITY OF VIRGINIALocation CHARLOTTESVILLE, UNITED STATESPosted 1 Apr 2024Deadline 31 Mar 2028
NIHUS FederalResearch GrantFY20251,25-Dihydroxycholecalciferol Receptors1,25-Dihydroxyvitamin D 3 Receptors1,25-Dihydroxyvitamin D3 Receptors1-Alpha-Hydroxylase21+ years old25-Hydroxyvitamin D3-1-Alpha-HydroxylaseAdultAdult HumanAffectAlbuminuriaAnimalsArchivesBindingBirthBlood PressureBlood SerumBolusBolus InfusionCYP27B1CYP27B1 geneCalcitriol ReceptorsCell BodyCell DifferentiationCell Differentiation processCellsCells Placenta-TissueCholecalciferol ReceptorsChronic Kidney FailureChronic Renal DiseaseChronic Renal FailureClinicalClinical TrialsCytochrome P450, Subfamily XXVIIB, Polypeptide 1DevelopmentDietDiseaseDisorderDoseDysfunctionExposure toFaceFatsFatty acid glycerol estersFormulationFoundationsFunctional disorderFutureGene ExpressionGene TranscriptionGenetic TranscriptionGestationGlomerular diseaseGoalsHealthHumanImpairmentIn VitroIndividualInjuryIntermediary MetabolismKidneyKidney DiseasesKidney Urinary SystemLungLung Respiratory SystemMeasuresMetabolic ProcessesMetabolismMiceMice MammalsMicronutrientsModelingModern ManModificationMolecularMolecular InteractionMothersMurineMusNPHS1 gene productNephropathyNormal PlacentomaNuclearNutritionalOrganOutcomeP450C1-AlphaParturitionPathogenesisPathway interactionsPerinatalPeripartumPhenotypePhysiopathologyPlacentaPlacenta Embryonic TissuePlacentomePregnancyPremature BirthPremature InfantPrematurely deliveringPreterm BirthRNA ExpressionRNA SeqRNA sequencingRNAseqRenal DiseaseRenal Glomerular Diseases and SyndromesRenal functionRenal glomerular diseaseRenal glomerular disease or syndromeRenal glomerular disorderRenal glomerular syndromeReportingResearchResolutionRetinaRiskRoleSafetySamplingSerumSourceSupplementation with vitamin DTestingTherapeuticTranscriptionUnderserved PopulationUnited StatesVIT DVisceral Epithelial CellVitamin DVitamin D 3 ReceptorsVitamin D DeficiencyVitamin D ReceptorsVitamin D supplementationVitamin D3 ReceptorVitaminsWorkadulthoodantagonismantagonistcellular differentiationchronic kidney diseaseclinical practicedensitydevelopmentaldietsearly onsetextreme prematurityextremely premature infantextremely pretermextremely preterm infantfacesfacialgastrointestinalglomerular filtrationglomerular visceral epithelial cellhigh riskimprovedin vivoinfants born prematureinfants born prematurelyinjurieskidney developmentkidney disorderkidney functionmouse modelmurine modelneonatal miceneonatenephrinnephrogenesisnovelnutritiousoffspringpathophysiologypathwayplacental transferpodocytepremature babypremature childbirthpremature deliverypremature infant humanpremature neonatespremature newbornpreterm babypreterm deliverypreterm infantpreterm infant humanpreterm neonatepreterm newbornpreventpreventingprimary outcomepulmonarypuprenalrenal disorderresolutionsrisk mitigationsecondary outcomesocial roletranscriptome sequencingtranscriptomic sequencingtranscriptomicsunder served groupunder served individualunder served peopleunder served populationunderserved groupunderserved individualunderserved peopleurinaryvery prematurevery pretermvitamin D supplement
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PROJECT SUMMARY/ABSTRACT
Vitamin D deficiency is common in neonates born preterm and implicated the pathogenesis disease in several
organs, such as the lung and retina. In the kidney, vitamin D supplementation clearly prevents the loss of a
podocytes in animals with glomerular disease. The podocyte is a terminally differentiated cell vital to the…
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