grant
Investigating structural and biochemical factors guiding concanamycin A biosynthesis
Organization UNIVERSITY OF MICHIGAN AT ANN ARBORLocation ANN ARBOR, UNITED STATESPosted 1 Aug 2025Deadline 30 Jun 2028
NIHUS FederalResearch GrantFY20253-D3-D structure3-Dimensional3-dimensional structure3D3D structureAIDS VirusAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusAddressAnabolismAntibiotic AgentsAntibiotic DrugsAntibioticsArchitectureBacteriaBiochemicalBiologicalBiomedical EngineeringCell BodyCell Communication and SignalingCell ComponentsCell SignalingCell StructureCellsCellular StructuresChemicalsComplexCoupledCryo-electron MicroscopyCryo-electron tomographyCryoelectron MicroscopyCulture MediaDataDerivationDerivation procedureDockingDrugsE-MycinElectron CryomicroscopyElectron MicroscopyEngineeringEngineering / ArchitectureEry-TabErycErydermErythrocinErythromycinErythromycin AFDA approvedFermentationGenerationsHIVHIV InfectionsHTLV-III InfectionsHTLV-III-LAV InfectionsHuman Immunodeficiency VirusesHuman T-Lymphotropic Virus Type III InfectionsHydrophobic InteractionsIlotycinImmune responseImmune signalingImmunosuppressantsImmunosuppressive AgentsImmunosuppressive drugImmunosuppressive treatmentIn SituIndividualIntermediary MetabolismIntracellular Communication and SignalingInvestigationIvermectinKnowledgeLAV-HTLV-IIILC/MSLipidsLymphadenopathy-Associated VirusMacrolidesMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMediatingMedicationMetabolic ProcessesMetabolismMiscellaneous AntibioticModelingMolecularMolecular ProbesNatural ProductsNaturePKS enzymePathway interactionsPediamycinPharmaceutical AgentPharmaceutical PreparationsPharmaceuticalsPharmacologic SubstancePharmacological SubstanceProcessProductionPropertyProteinsProteomeProteomicsRP-MycinRapamuneRapamycinReporterResearchResolutionRobimycinRoleRouteSamplingSignal TransductionSignal Transduction SystemsSignalingSingle Crystal DiffractionSirolimusSodium ChlorideSpectroscopySpectrum AnalysesSpectrum AnalysisSpinal ColumnSpineStreptomycesStructureSystemTherapeuticTherapeutic AgentsTherapeutic FungicidesTimeType I Polyketide SynthaseUltracentrifugationVertebral columnViral DiseasesViral Gene ProductsViral Gene ProteinsViral ProteinsVirus DiseasesVirus-HIVWorkX Ray CrystallographiesX-Ray CrystallographyX-Ray Diffraction CrystallographyX-Ray/Neutron CrystallographyXray Crystallographyanaloganti-fungalanti-fungal agentsanti-fungal drugbackbonebio-engineeredbio-engineersbioengineeringbiologicbiological engineeringbiological signal transductionbiosynthesiscrosslinkcryo-EMcryo-EM tomographycryoEMcryoEM tomographycryoelectron tomographycryogenic electron microscopycryogenicsdrug/agentelectron cryo-tomographyexperimentexperimental researchexperimental studyexperimentsfascinateflexibilityflexiblegrowth mediahost responseimmune suppressive agentimmune suppressorimmune system responseimmunoresponseimmunosuppressive substanceimmunosuppressorimprovedinsightlight microscopylipid solubilityliquid chromatography mass spectrometrymembermutantnanonaturally occurring productnovelparticlepathwaypharmaceuticalpharmacologicpolyketide synthasepolyketidesresolutionsrestraintsaltsocial rolethree dimensionalthree dimensional structureviral infectionvirus infectionvirus proteinvirus-induced disease
Description preview
Proposal Summary
Bacteria produce a wide array of diverse natural products through secondary metabolism. Polyketides stand out
in this group of metabolites owing to their remarkable chemical complexity and varied bioactivities. This
fascinating group of natural products includes FDA-approved antibiotics, antifungals, immunosuppressants, and
many…
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