grant
Investigating stochastic genome folding as a mechanism to generate cell-surface protein diversity required for neural self-avoidance
Organization UNIVERSITY OF CALIFORNIA, SAN FRANCISCOLocation SAN FRANCISCO, UNITED STATESPosted 1 Mar 2024Deadline 28 Feb 2029
NIHUS FederalResearch GrantFY20253-D3-Dimensional3DAblationAddressAllelesAllelomorphsArchitectureAssayBase PairingBioassayBiologic ModelsBiological AssayBiological ModelsBrainBrain Nervous SystemCell BodyCell Culture SystemCell Surface ProteinsCellsChromatinChromatin LoopChromatin Loop DomainsChromosomesComplexCoupledCouplingDNA LoopDNA MethylationDataDecision MakingDevelopmentDiseaseDisorderEncephalonEngineering / ArchitectureEnhancersGene Action RegulationGene ArrangementGene ClusterGene ExpressionGene Expression RegulationGene InactivationGene OrderGene PositionGene RegulationGene Regulation ProcessGene SilencingGene TranscriptionGenerationsGenesGeneticGenetic TranscriptionGenomeGenomic DNAGenomic approachGoalsHealthHeterochromatinHumanIndividualInstructionIsoformsLabelLifeLinkMaintenanceMammaliaMammalsMapsMeasuresMemoryMiceMice MammalsModel SystemModelingModern ManMolecularMurineMusNamesNatureNerve CellsNerve UnitNervous System DiseasesNervous System DisorderNeural CellNeural DevelopmentNeuritesNeurocyteNeurologic DisordersNeurological DisordersNeuronsNon-Polyadenylated RNANuclearOpticsPatternPhysiologicPhysiologicalPlayProcessProgenitor CellsPropertyProtein IsoformsProteinsProteomePublishingRNARNA ExpressionRNA Gene ProductsReaderRegulationResearch ProposalsResolutionRestRibonucleic AcidRoleShapesStructureTestingTranscriptTranscriptioncell typecohesincombinatorialdevelopmentalgDNAgenomic effortgenomic strategyhistone methylationin vivomouse modelmurine modelnamenamednamingneuralneural circuitneural circuitryneural controlneural patterningneural regulationneurocircuitryneurodevelopmentneurological diseaseneuromodulationneuromodulatoryneuronalneuropsychiatric diseaseneuropsychiatric disorderneuroregulationolfactory sensory neuronsopticalpostmitoticpreventpreventingpromoterpromotorprotein complexreconstructionresolutionssingle cell genomicssocial rolestem cellssynaptic circuitsynaptic circuitrythree dimensionaltranscriptional silencing
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PROJECT SUMMARY
During brain development, the assembly of functional neural circuits necessitates sophisticated regulation of
neural arborization patterns. This mechanism is achieved by a process known as neural self-avoidance, which
allows projections from the same neuron to recognize and avoid self. In mammals, the regulation of neural self-…
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