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Investigating spatial and temporal heterogeneity in mitochondria during aging using in vivo high-content chemical imaging

Organization GEORGIA INSTITUTE OF TECHNOLOGYLocation ATLANTA, UNITED STATESPosted 1 Aug 2024Deadline 30 Apr 2026 ⚠️
NIHUS FederalResearch GrantFY20252-photonAD dementiaAD modelAddressAgeAgingAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimer's disease modelAlzheimers DementiaAnimalsAreaAutoregulationBiologic ModelsBiological ModelsBiologyBody TissuesC elegansC. elegansC.elegansCaenorhabditis elegansCell BodyCell Communication and SignalingCell FunctionCell PhysiologyCell ProcessCell SignalingCellsCellular FunctionCellular PhysiologyCellular ProcessCellular biologyCharacteristicsChemicalsDNA mutationDataDetectionDevelopmentDiseaseDisorderDysfunctionEnergy ExpenditureEnergy MetabolismEnvironmentEpidermisExhibitsFLIM imagingFluorescence AgentsFluorescence Light MicroscopyFluorescence MicroscopyFluorescent AgentsFluorescent DyesFunctional disorderGenetic ChangeGenetic ModelsGenetic defectGenetic mutationGerm LinesGripsHeterogeneityHomeostasisImageImaging ProceduresImaging TechnicsImaging TechniquesIndividualIntermediary MetabolismIntestinalIntestinesIntracellular Communication and SignalingIonsLabelLinkLipidsLocationMachine LearningMapsMetabolicMetabolic ProcessesMetabolismMitochondriaModel SystemModelingMorphologyMuscleMuscle TissueMutationNematodaNematodesNerve CellsNerve UnitNeural CellNeurocyteNeuronsOrganellesOrganismPhysiologicPhysiologic MonitoringPhysiologicalPhysiological HomeostasisPhysiological MonitoringPhysiologyPhysiopathologyPlayPositionPositioning AttributePrimary Senile Degenerative DementiaPublishingRegulationReporterResearchRoleShapesSignal PathwaySignal TransductionSignal Transduction SystemsSignalingStaining methodStainsStructureSubcellular ProcessSynapsesSynapticTechniquesTissuesVariantVariationage associatedage correlatedage dependentage groupage linkedage relatedage specificagesalzheimer modelbiological signal transductionbowelcell biologycell typedevelopmentalenergy balancefitnessfluorescence imagingfluorescence life-time imagingfluorescence life-time imaging microscopyfluorescence lifetime imagingfluorescence lifetime imaging microscopyfluorescent dye/probefluorescent imaginggenome mutationgraspimagingimaging approachimaging based approachimaging in vivoimprovedin vivoin vivo Modelin vivo imaginginnovateinnovationinnovativeinsightlife spanlifespanliving systemmachine based learningmitochondrialmitochondrial dysfunctionmodel organismmuscularneuronalnew approachesnovelnovel approachesnovel strategiesnovel strategyold ageparticlepathophysiologyprimary degenerative dementiaroundwormsenile dementia of the Alzheimer typesocial rolespatial and temporalspatial temporalspatiotemporalsynapsetooltwo-photonyounger age

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PROJECT SUMMARY
Title: Investigating spatial and temporal heterogeneity in mitochondria during aging using in vivo high-
content chemical imaging
The spatial and temporal regulation of mitochondria is critical for controlling various cellular processes, including
energy balance and metabolism, in specific locations and timeframes. Mitochondria…

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