grant
Investigating Relationships of the Upper Airway Microbiota with SARS-CoV-2 Susceptibility and Coronavirus Disease 2019 Disease Presentation
Organization VANDERBILT UNIVERSITYLocation Nashville, UNITED STATESPosted 1 Apr 2026Deadline 31 Mar 2028
NIHUS FederalResearch GrantFY202616S RNA sequencing16S RNAseq16S gene sequencing16S rDNA amplicon sequencing16S rRNA DNA sequencing16S rRNA amplicon sequencing16S rRNA gene amplicon sequencing16S rRNA gene sequencing16S rRNA genomic profiling16S rRNA sequencing16S ribosomal RNA gene sequencing16S ribosomal RNA sequencing16S seq16S sequencing16s rRNA seq2019 novel corona virus2019 novel coronavirus2019-nCoV2019-nCoV variant2019-nCoV variant forms2019-nCoV variant strainsAcademic Medical CentersAchievementAchievement AttainmentActive Follow-upAcuteAddressAgeBiological MarkersCOVID disease severityCOVID severityCOVID-19COVID-19 associated deathCOVID-19 associated fatalityCOVID-19 associated mortalityCOVID-19 deathCOVID-19 disease severityCOVID-19 exposureCOVID-19 fatalityCOVID-19 induced deathCOVID-19 induced fatalityCOVID-19 induced mortalityCOVID-19 infectionCOVID-19 mortalityCOVID-19 predispositionCOVID-19 related deathCOVID-19 related fatalityCOVID-19 related mortalityCOVID-19 severityCOVID-19 susceptibilityCOVID-19 therapyCOVID-19 treatmentCOVID-19 variantCOVID-19 variant formsCOVID-19 variant strainsCOVID-19 virusCOVID-19 virus infectionCOVID-19 vulnerabilityCOVID19 associated deathCOVID19 associated fatalityCOVID19 associated mortalityCOVID19 deathCOVID19 disease severityCOVID19 fatalityCOVID19 induced deathCOVID19 induced fatalityCOVID19 induced mortalityCOVID19 infectionCOVID19 mortalityCOVID19 related deathCOVID19 related fatalityCOVID19 related mortalityCOVID19 severityCOVID19 virusCV-19Centers for Disease ControlCenters for Disease Control and PreventionCenters for Disease Control and Prevention (U.S.)Cessation of lifeCharacteristicsCirculationClinicalClinical DataCoV-2CoV2Coronavirus Infectious Disease 2019Coronavirus disease 2019 predispositionCoronavirus disease 2019 susceptibilityCoronavirus disease 2019 vulnerabilityDataData SetDeathDiagnostic FindingsDiathesisDiseaseDisease susceptibilityDisorderEssential employeeEssential personEssential personnelEssential staffEssential workerEvaluationFrequenciesFutureGeneral Prognostic FactorGrippeHouseholdImmunityIndividualInfectionInfluenzaInfluenza AInfluenza A virusInfluenza BInfluenza B VirusInfluenza Viruses Type AInfluenza Viruses Type BInfluenzavirus AIntubationLaboratoriesLife ExpectancyLinkLong COVIDLong COVID-19Long coronavirus diseaseLong coronavirus disease 2019Longitudinal StudiesLongitudinal SurveysMethodsNatureOrthomyxovirus Type AOrthomyxoviruses Type BOutcomeParticipantPredisposed to COVID-19Predisposed to SARS-CoV-2Predisposed to Severe acute respiratory syndrome coronavirus 2PredispositionPreventative interventionPreventionPrognostic FactorPrognostic/Survival FactorPublic HealthReportingResearch SpecimenRespiratory syncytial virusRiskRoleSARS corona virus 2SARS-CO-V2SARS-COVID-2SARS-CoV-2SARS-CoV-2 associated deathSARS-CoV-2 associated fatalitySARS-CoV-2 associated mortalitySARS-CoV-2 deathSARS-CoV-2 disease severitySARS-CoV-2 exposureSARS-CoV-2 fatalitySARS-CoV-2 induced deathSARS-CoV-2 induced fatalitySARS-CoV-2 induced mortalitySARS-CoV-2 infectionSARS-CoV-2 mortalitySARS-CoV-2 predispositionSARS-CoV-2 related deathSARS-CoV-2 related fatalitySARS-CoV-2 related mortalitySARS-CoV-2 severitySARS-CoV-2 susceptibilitySARS-CoV-2 therapySARS-CoV-2 treatmentSARS-CoV-2 variantSARS-CoV-2 variant formsSARS-CoV-2 variant strainsSARS-CoV-2 vulnerabilitySARS-CoV2SARS-CoV2 exposureSARS-CoV2 infectionSARS-associated corona virus 2SARS-associated coronavirus 2SARS-coronavirus-2SARS-related corona virus 2SARS-related coronavirus 2SARSCoV2Sample SizeSamplingSevere Acute Respiratory Coronavirus 2Severe Acute Respiratory Distress Syndrome CoV 2Severe Acute Respiratory Distress Syndrome Corona Virus 2Severe Acute Respiratory Distress Syndrome Coronavirus 2Severe Acute Respiratory Syndrome CoV 2Severe Acute Respiratory Syndrome-associated coronavirus 2Severe Acute Respiratory Syndrome-related coronavirus 2Severe acute respiratory syndrome associated corona virus 2Severe acute respiratory syndrome coronavirus 2Severe acute respiratory syndrome coronavirus 2 exposureSevere acute respiratory syndrome coronavirus 2 infectionSevere acute respiratory syndrome coronavirus 2 predispositionSevere acute respiratory syndrome coronavirus 2 susceptibilitySevere acute respiratory syndrome coronavirus 2 vulnerabilitySevere acute respiratory syndrome related corona virus 2SeveritiesSeverity of illnessSigns and SymptomsSiteSmokingSpecimenStratificationSusceptibilitySymptomsTestingTherapeuticTherapeutic InterventionTransmissionType A InfluenzaUnited StatesUnited States Centers for Disease ControlUnited States Centers for Disease Control and PreventionUniversity Medical CentersVaccinationVirusWorkWuhan coronavirusactive followupacute COVID-19acute SARS-CoV-2 infectionacute phase of COVID-19acute phase of SARS-CoV-2 infectionacute symptomadverse consequenceadverse outcomeagesairway microbial communityairway microbiotabio-markersbiologic markerbiomarkerchronic COVIDchronic COVID-19chronic novel coronavirus disease 2019co-morbidco-morbiditycomorbiditycoronavirus disease 2019coronavirus disease 2019 associated deathcoronavirus disease 2019 associated fatalitycoronavirus disease 2019 associated mortalitycoronavirus disease 2019 deathcoronavirus disease 2019 disease severitycoronavirus disease 2019 exposurecoronavirus disease 2019 fatalitycoronavirus disease 2019 induced deathcoronavirus disease 2019 induced fatalitycoronavirus disease 2019 induced mortalitycoronavirus disease 2019 infectioncoronavirus disease 2019 mortalitycoronavirus disease 2019 related deathcoronavirus disease 2019 related fatalitycoronavirus disease 2019 related mortalitycoronavirus disease 2019 severitycoronavirus disease 2019 therapycoronavirus disease 2019 treatmentcoronavirus disease 2019 variantcoronavirus disease 2019 variant formscoronavirus disease 2019 variant strainscoronavirus disease 2019 viruscoronavirus disease severitycoronavirus disease-19coronavirus disease-19 mortalitycoronavirus disease-19 viruscoronavirus infectious disease-19death due to COVID-19death due to COVID19death due to SARS-CoV-2death due to coronavirus disease 2019death due to severe acute respiratory syndrome coronavirus 2death in COVIDdeath in COVID-19death in SARS-CoV-2death in coronavirus diseasedeath in coronavirus disease 2019death in severe acute respiratory syndrome coronavirus 2disease riskdisease severitydisorder riskexperienceexposure to COVID-19exposure to SARS-CoV-2exposure to SARS-CoV2exposure to Severe acute respiratory syndrome coronavirus 2exposure to coronavirus disease 2019fatality due to COVID-19fatality due to COVID19fatality due to SARS-CoV-2fatality due to coronavirus disease 2019fatality due to severe acute respiratory syndrome coronavirus 2flufollow upfollow-upfollowed upfollowuphCoV19improvedinfected with COVID-19infected with COVID19infected with SARS-CoV-2infected with SARS-CoV2infected with coronavirus disease 2019infected with severe acute respiratory syndrome coronavirus 2infection with SARS-CoV-2intervention for preventionintervention therapyliability to diseaselife-style factorlifestyle factorslong haul COVIDlong haul COVID-19long haul coronavirus diseaselong haul coronavirus disease 2019long-hauler COVIDlong-hauler COVID-19long-hauler coronavirus disease 2019long-hauler syndromelong-term COVIDlong-term COVID-19long-term coronavirus diseaselong-term coronavirus disease 2019long-term studylongitudinal designlongitudinal experimental designlongitudinal outcome studieslongitudinal research designlongitudinal research studylongitudinal study designmanage symptommembermicrobial consortiamicrobial floramicrobiotamicrobiota compositionmicrofloramortality due to COVID-19mortality due to COVID19mortality due to SARS-CoV-2mortality due to coronavirus disease 2019mortality due to severe acute respiratory syndrome coronavirus 2multispecies consortianCoV2nasal swabpersistent COVID-19post COVID syndromepost COVID-19 syndromepost acute COVID syndromepost acute COVID-19post acute COVID-19 syndromepost acute SARS-CoV-2post acute coronavirus disease 2019post acute coronavirus disease 2019 syndromepost acute coronavirus disease syndromepost acute severe acute respiratory syndrome coronavirus 2post coronavirus disease 2019 syndromepost coronavirus disease syndromepost-COVID conditionspost-acute phases of COVID-19predisposed to Coronavirus disease 2019prevention interventionpreventional intervention strategypreventive interventionprolonged COVID-19 symptomsprospectiverespiratoryrespiratory microbiotarespiratory virussevere acute respiratory syndrome coronavirus 2 associated deathsevere acute respiratory syndrome coronavirus 2 associated fatalitysevere acute respiratory syndrome coronavirus 2 associated mortalitysevere acute respiratory syndrome coronavirus 2 deathsevere acute respiratory syndrome coronavirus 2 disease severitysevere acute respiratory syndrome coronavirus 2 fatalitysevere acute respiratory syndrome coronavirus 2 induced deathsevere acute respiratory syndrome coronavirus 2 induced fatalitysevere acute respiratory syndrome coronavirus 2 induced mortalitysevere acute respiratory syndrome coronavirus 2 mortalitysevere acute respiratory syndrome coronavirus 2 related deathsevere acute respiratory syndrome coronavirus 2 related fatalitysevere acute respiratory syndrome coronavirus 2 related mortalitysevere acute respiratory syndrome coronavirus 2 severitysevere acute respiratory syndrome coronavirus 2 therapysevere acute respiratory syndrome coronavirus 2 treatmentsevere acute respiratory syndrome coronavirus 2 variantsevere acute respiratory syndrome coronavirus 2 variant formssevere acute respiratory syndrome coronavirus 2 variant strainssexsocial rolestemsusceptible to COVID-19susceptible to Coronavirus disease 2019susceptible to SARS-CoV-2susceptible to Severe acute respiratory syndrome coronavirus 2symptom managementtransmission processtreat COVID-19treat SARS-CoV-2treat coronavirus disease 2019treat severe acute respiratory syndrome coronavirus 2viral transmissionvirus transmissionvulnerable to COVID-19vulnerable to Coronavirus disease 2019vulnerable to SARS-CoV-2vulnerable to Severe acute respiratory syndrome coronavirus 2
Description preview
PROJECT SUMMARY/ABSTRACT
Coronavirus disease 2019 (COVID-19), caused by the SARS-CoV-2 virus, has had a worldwide impact with an
estimation of over 775 million cases and seven million deaths. In 2020 and 2021, the United States saw a decline
in life expectancy due to excess deaths due to COVID-19. Fortunately, the current era with effective…
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