grant
Investigating regulatory mechanisms of the AP1 transcription factor in hypoxic (low oxygen) cell adaptation
Organization UKRILocation United Kingdom
UKRIUK ResearchGrantActive
Description preview
We plan to test the hypothesis that components of the AP-1 transcription factor are activated in response to key hypoxic signalling pathways and reactive oxygen species (ROS) induced post translational modifications.
Specifically we will:
(1) Identify key hypoxic signalling pathways that regulate AP-1 protein activity in hypoxia using a CRISPR…
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