grant
Investigating personalized approaches to de-intensify therapy for nodular lymphocyte-predominant Hodgkin lymphoma
Organization STANFORD UNIVERSITYLocation STANFORD, UNITED STATESPosted 1 Aug 2024Deadline 31 Jul 2029
NIHUS FederalResearch GrantFY2025AddressAfter CareAfter-TreatmentAftercareAssayB lymphomaB-Cell LymphomasBioassayBioinformaticsBiological AssayBiometricsBiometryBiopsyBiostatisticsBlood PlasmaBlood SampleBlood specimenBody TissuesBrill-Symmers DiseaseCancer BiologyCardiac ToxicityCardiotoxicCardiotoxicityCardiovascular DiseasesCareer Development AwardsCareer Development Awards and ProgramsCareer Development Programs K-SeriesCell BodyCellsCessation of lifeChemotherapy and RadiationChemotherapy and/or radiationClinicalClinical ProtocolsClinical TrialsCoronary ArteriosclerosisCoronary Artery DiseaseCoronary Artery DisorderCoronary AtherosclerosisCustomDNA mutationDataDeathDevelopmentDevelopment PlansDiagnosisDiagnosticDiseaseDisorderDoctor of PhilosophyEcologic SystemsEcological SystemsEcosystemFollicle Center LymphomaFollicular LymphomaFollicular Non-Hodgkin's LymphomaFoundationsFutureGene ExpressionGene Expression MonitoringGene Expression Pattern AnalysisGene Expression ProfilingGenesGeneticGenetic ChangeGenetic RiskGenetic defectGenetic mutationGenomicsGenotypeGerminoblastic SarcomaGerminoblastomaGiant Follicular LymphomaGoalsHematologic CancerHematologic MalignanciesHematologic NeoplasmsHematological MalignanciesHematological NeoplasmsHematological TumorHematopoietic CancerHereditaryHistiocytic LymphomaHodgkin DiseaseHodgkin DisorderHodgkin lymphomaHodgkin'sHodgkin's LymphomaHodgkin's diseaseHodgkins lymphomaHumanHybrid captureHybridization captureImmuneImmunesInheritedK-AwardsK-Series Research Career ProgramsKnowledgeLarge-Cell LymphomasLymphatic cellLymphocyteLymphocyticLymphomaMalignantMalignant - descriptorMalignant Hematologic NeoplasmMalignant LymphogranulomaMalignant LymphomaMeasurableMeasuresMentorshipMethodsModern ManMorbidityMorbidity - disease rateMutateMutationNodular LymphomaOrphan DiseaseOutcomePatient SelectionPatientsPersonalized medical approachPh.D.PhDPhenotypePlasmaPlasma SerumPredictive FactorPrognostic MarkerProgression-Free SurvivalsRNA SeqRNA sequencingRNAseqRaceRacesRadiation OncologyRadiation therapyRadiotherapeuticsRadiotherapyRare DiseasesRare DisorderRecurrenceRecurrentRegulationRelapseResearchResearch Career ProgramReticuloendothelial System, Serum, PlasmaReticulolymphosarcomaReticulosarcomaReticulum-Cell SarcomaRiskRisk-associated variantSamplingSelection for TreatmentsSomatic CellTestingTissuesToxic effectToxicitiesTrainingTranscript Expression AnalysesTranscript Expression AnalysisTranslational Research EnterpriseTumor BurdenTumor LoadUniversitiesactive methodactive techniqueactive treatmentanalyze gene expressionatherosclerotic coronary diseasebiomarker identificationcancer immunologycardiovascular disease riskcardiovascular disordercardiovascular disorder riskcardiovascular riskcardiovascular risk factorcareercareer developmentcell transformationcell typechemo/radiation therapychemotherapychemotherapy and radiotherapyclinically actionablecomputer based predictionconferenceconventioncoronary arterial diseasecustomsdata managementdesigndesigningdevelopmentaldisease riskdisorder riskexperiencegene expression analysisgene expression assaygenome mutationgenomic biomarkergenomic markergenotyped patientsglobal gene expressionglobal transcription profilehigh riskhybridization-based captureidentification of biomarkersidentification of new biomarkersimprovedindividualized approachliquid biopsylymph cellmalignant lymphocytemarker identificationmedical collegemedical schoolsmortalityneoplasm immunologynovelorphan disorderoutcome predictionpersonalization of treatmentpersonalized approachpersonalized medicinepersonalized therapypersonalized treatmentpost treatmentprecision approachpredict clinical outcomepredictive modelingprofessorprognosticprognostic abilityprognostic biomarkerprognostic indicatorprognostic powerprognostic utilityprognostic valueprogramsprogression riskprospectiveprotein biomarkersprotein markersracialracial backgroundracial originradiation or chemotherapyradiation treatmentrisk allelerisk generisk genotyperisk locirisk locusrisk variantscRNA sequencingscRNA-seqschool of medicineselection of treatmentsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingspatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicsstandard carestandard treatmentstatisticssummitsurveillance strategysymposiasymposiumtailored approachtargeted sequencingtherapy optimizationtherapy selectiontooltranscriptional profilingtranscriptometranscriptome sequencingtranscriptomic sequencingtranscriptomicstransformed cellstranslation research enterprisetranslational research programtreatment optimizationtreatment selectiontreatment with radiationtumortumor DNAtumor cell DNAtumor immunologytumor-specific DNAwork groupworking group
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PROJECT SUMMARY/ABSTRACT:
Michael Binkley, MD, MS is an Assistant Professor of Radiation Oncology at Stanford
University School of Medicine. His long-term career goal is to combine his expertise in managing
patients with hematologic malignancies with his research expertise in statistics, genomics, and
cancer biology to develop improved treatment…
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