grant
Investigating opioid-induced dopamine rhythms and their role in respiratory suppression
Organization STANFORD UNIVERSITYLocation STANFORD, UNITED STATESPosted 15 May 2026Deadline 30 Apr 2028
NIHUS FederalResearch GrantFY20264-Aminobutanoic Acid4-Aminobutyric Acid4-amino-butanoic acidAbsence of pain sensationAbsence of sensibility to painActiqAdvisory CommitteesAffectAlternative TherapiesAlternative interventionAminalonAminaloneAnalgesic AgentsAnalgesic DrugsAnalgesic PreparationAnalgesicsAnimalsAnodynesAntinociceptive AgentsAntinociceptive DrugsBehaviorBehavioralBrainBrain Nervous SystemBreathingCause of DeathCell BodyCell Communication and SignalingCell FunctionCell PhysiologyCell ProcessCell SignalingCellsCellular FunctionCellular PhysiologyCellular ProcessCessation of lifeChemicalsChronicComplexCyclicityDA NeuronDataDeathDockingDoctor of PhilosophyDopamineDopamine neuronDoseDrug ExposureDrugsDuragesicElectric CapacitanceElectrical CapacitanceElectrophysiologyElectrophysiology (science)EncephalonEnvironmentExhibitsFeels no painFentanestFentanylFentylFrequenciesGABAGene TranscriptionGenerationsGenesGeneticGenetic TranscriptionGoalsHydroxytyramineHypoxiaHypoxicIntracellular Communication and SignalingInvestigatorsLaboratory ResearchMeasuresMedicationMedicinal ChemistryMembraneMembrane PotentialsMentorsMentorshipMiceMice MammalsModelingMolecularMolecular TargetMurineMusNaloxoneNarcanNarcantiNerve CellsNerve UnitNeural CellNeurocyteNeuronsNeurophysiology / ElectrophysiologyNeurosciencesNo sensitivity to painNucleus AccumbensOpiatesOpioidOxygen DeficiencyPatternPeriodicityPh.D.PhDPharmaceutic ChemistryPharmaceutical ChemistryPharmaceutical PreparationsPhasePhentanylPlayPostdocPostdoctoral FellowPreventionPropertyRNA ExpressionReportingReproducibilityResearchResearch AssociateResearch PersonnelResearchersResistanceRespirationRespiratory AspirationRespiratory DepressionRespiratory InspirationRestResting PotentialsRhythmicityRiskRodentRodentiaRodents MammalsRoleRunningSafetySalineSaline SolutionSignal TransductionSignal Transduction SystemsSignalingStereotypingStressSubcellular ProcessSystemTask ForcesTechniquesTestingTherapeuticTrainingTranscriptionTransmembrane PotentialsUniversitiesVentilatory DepressionVentral Tegmental AreaWorkabortionaddictionaddictive disorderadvisory teamanalgesiabiological signal transductionbrain tissuecapacitancecareercellular targetingcohortdepressed breathingdepression of breathingdopaminergic neurondrug developmentdrug discoverydrug/agentelectrophysiologicalfentanyl exposurefentanyl usegamma-Aminobutyric Acidgenetic approachgenetic strategyinspirationmembrane structuremesolimbic dopamine systemmesolimbic systemneural circuitneural circuitryneural mechanismneurocircuitryneuromechanismneuronalnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapeutic targetnew therapy approachesnew therapy targetnew treatment approachnew treatment strategynovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapeutic targetnovel therapy approachnovel therapy targetopiate consumptionopiate crisisopiate deathsopiate drug useopiate intakeopiate mortalityopiate overdoseopiate related overdoseopiate useopiate use disorderopioid associated apneaopioid associated respiratory depressionopioid consumptionopioid crisisopioid deathsopioid drug overdoseopioid drug useopioid epidemicopioid induced hypoventilationopioid induced overdoseopioid induced respiratory depressionopioid intakeopioid intoxicationopioid mediated respiratory depressionopioid medication overdoseopioid mortalityopioid overdoseopioid overdose deathopioid poisoningopioid related deathopioid related overdoseopioid related respiratory depressionopioid respiratory depressionopioid toxicityopioid useopioid use disorderopioid ventilatory depressionoptogeneticsoverdose deathoverdose fatalitiespain killerpain medicationpain reliefpain relieverpainkillerpatch clamppharmacologicpositive allosteric modulatorpost-docpost-doctoralpost-doctoral traineepreventpreventingrelieve painresearch associatesresistantrespiratoryrespiratory depression caused by opioidsrespiratory depression due to opioidsrespiratory mechanismresponsescRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingskillssocial rolesub-cellular targetingsubcellular targetingsynaptic circuitsynaptic circuitrytheoriesventral tegmentumγ-Aminobutyric Acid
Description preview
Project Summary
Opioid overdose, particularly from fentanyl, is the leading cause of drug-related deaths in the U.S., largely due
to opioid-induced respiratory depression (OIRD). Tolerance to opioids' euphoric and analgesic effects develop
faster than tolerance to their respiratory effects, increasing the risk of fatal overdose. Naloxone reverses…
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