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Investigating IGF2BP1 as a novel Therapeutic Target for Ewing Sarcoma
Organization DANA-FARBER CANCER INSTLocation BOSTON, UNITED STATESPosted 3 Apr 2024Deadline 25 Jul 2025 ⚠️
NIHUS FederalResearch GrantFY20250-11 years old3' Untranslated Regions3'UTRAcuteAdenosineAffectAnchorage-Independent GrowthAssayAttenuatedBasal Transcription FactorBasal transcription factor genesBindingBioassayBiochemicalBiological AssayBiologyBone CancerCLIP-SeqCRISPRCRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas systemCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCancer GenesCancer-Promoting GeneCancersCas nuclease technologyCell BodyCell CycleCell DeathCell Division CycleCell LineCell SurvivalCell ViabilityCellLineCellsCellular ExpansionCellular GrowthChemicalsChemotherapy ProtocolChemotherapy RegimenChemotherapy-Oncologic ProcedureChildChild YouthChildhoodChildhood CancersChildhood Solid NeoplasmChildhood Solid TumorChildren (0-21)Chimera ProteinChimeric ProteinsClustered Regularly Interspaced Short Palindromic RepeatsClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyCombination Chemotherapy RegimenComplexDNADataData BasesDatabasesDeoxyribonucleic AcidDependenceDiseaseDisease remissionDisorderDropsDrug CombinationsDrugsEWSR2Enzyme GeneEnzymesEventEwing Sarcoma Breakpoint Region 2Ewing's Family of TumoursEwing's Sarcoma/Peripheral Primitive Neuroectodermal TumorEwing's TumorEwings sarcomaFLI1FLI1 geneFellowshipFli-1 proto-oncogene, ETS transcription factorFriend leukemia virus integration 1Fusion ProteinFutureGeneral Transcription Factor GeneGeneral Transcription FactorsGeneralized GrowthGenesGeneticGrowthGuide RNAHITS-CLIPHigh-throughput sequencing of CLIP cDNA libraryImmune PrecipitationImmunoblottingImmunoprecipitationIn VitroInfectionInjectionsInvadedK Homology DomainKH DomainKnock-outKnockoutLibrariesLife ExpectancyLinkMaintenanceMalignant Bone NeoplasmMalignant CellMalignant Childhood NeoplasmMalignant Childhood TumorMalignant NeoplasmsMalignant Osseous NeoplasmMalignant Osseous TumorMalignant Pediatric NeoplasmMalignant Pediatric TumorMalignant TumorMalignant Tumor of the BoneMalignant childhood cancerMapsMediatingMedicationMessenger RNAMetastatic Ewing's SarcomaMethodsMiceMice MammalsMiningModificationMolecularMolecular InteractionMonitorMurineMusNatureNon-Polyadenylated RNAOncogenesOperative ProceduresOperative Surgical ProceduresOsseous CancerPDX modelPathogenesisPatient derived xenograftPatientsPediatric Solid TumorPharmaceutical PreparationsPhenotypePlayPositionPositioning AttributeProliferatingProteinsQuimioterapiaRNARNA Gene ProductsRNA SeqRNA sequencingRNA-Binding ProteinsRNAseqRadiation therapyRadiotherapeuticsRadiotherapyRecurrenceRecurrentRelapseRemissionRepressionResearchResearch ResourcesResistanceResourcesRibonucleic AcidRoleSIC-1Short interfering RNASmall Interfering RNAStandardizationStrains Cell LinesStructureSubstrate InteractionSurgicalSurgical InterventionsSurgical ProcedureSystemTestingTherapeuticTissue GrowthTrainingTranscriptTranscription Factor Proto-OncogeneTranscription factor genesTransforming GenesTumor BurdenTumor LoadWestern BlottingWestern ImmunoblottingWorkXenograft Modelattenuateattenuatesbonecancer cellcancer chemotherapycancer in a childcancer in childrencareercell growthcell transformationchild with cancerchildhood malignancycrosslinking and immunoprecipitation sequencingcultured cell linedata basedata miningdataminingdesigndesigningdrug/agentfunctional genomicsgRNAgenome editinggenomic editinggraduate schoolin vivoinhibitorinsightkidsmRNAmRNA DegradationmRNA Transcript Degradationmalignancynecrocytosisneoplasm/cancernew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetontogenypatient derived xenograft modelpediatricpediatric cancerpediatric malignancypost-doctoral trainingprotein blottingradiation treatmentresistantsiRNAskillssmall molecular inhibitorsmall molecule inhibitorsocial rolesurgerytherapeutic agent developmenttherapeutic developmenttherapeutic targettooltranscription factortranscriptome sequencingtranscriptomic sequencingtransformed cellstreatment with radiationtumortumorigenicxenograft transplant modelxenotransplant modelyoungster
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Project Summary
Ewing sarcoma (ES) is the second most prevalent bone cancer among children. Aggressive in nature, ES is
driven by a fusion transcription factor of which EWS/FLI1 accounts for ~85% of cases. Drugging EWS/FLI1 is
difficult, as it is highly disordered. New ES therapies that modulate novel therapeutic targets are urgently needed.…
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