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Investigating how cancer cells maintain redox homeostasis to support biomass production

Organization HARVARD MEDICAL SCHOOLLocation BOSTON, UNITED STATESPosted 1 Feb 2022Deadline 31 Jan 2026 ⚠️
NIHUS FederalResearch GrantFY20253-PyridinecarboxamideATP SynthesisATP Synthesis PathwayAffectAmino AcidsAutoregulationBiomassBody TissuesCaloric RestrictionCancer PatientCancer TreatmentCancer cell lineCancersCell BodyCell Growth in NumberCell MultiplicationCell ProliferationCellsCellular ProliferationCitratesClinicalConsumptionCoupledD-GlucoseDevelopmentDextroseEC 1.1.1.27EnvironmentEnzyme GeneEnzymesEquilibriumFatty AcidsFermentationGlnGlucoseGlutamineGoalsH+ elementHomeostasisHydrogen IonsIntermediary MetabolismL-GlutamineL-Lactate DehydrogenaseL-Lactic Acid DehydrogenaseL-SerineLactate DehydrogenaseLipidsMalignant CellMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMalignant NeoplasmsMalignant TumorMeasuresMediatorMetabolicMetabolic ProcessesMetabolismMitochondriaNAD-Lactate DehydrogenaseNADHNatural regenerationNiacinamideNicotinamideNicotinamidumNicotinic acid amideNicotylamideNon-Essential Amino AcidNonessential Amino AcidNucleotidesNutrientOncogenesisOxidantsOxidation-ReductionOxidative PhosphorylationOxidative Phosphorylation PathwayOxidizing AgentsPathway interactionsPellagra-Preventing FactorPhysiologicPhysiologicalPhysiological HomeostasisProcessProductionProliferatingProtein BiosynthesisProteinsProtonsPyruvateQ LevoglutamideQ. LevoglutamideReactionRedoxRegenerationResearchRespirationRibosomal Peptide BiosynthesisRibosomal Protein BiosynthesisRibosomal Protein SynthesisRoleSerineTestingTherapeuticTissuesVitamin B 3Vitamin B3Vitamin PPaminoacidanti-cancer therapybalancebalance functioncalorie restrictioncancer cellcancer cell metabolismcancer metabolismcancer therapycancer typecancer-directed therapycofactorcostdevelopmentaldietary restrictionelectron acceptorimprovedinsightinterestlactic acid dehydrogenasemalignancymitochondrialmouse modelmurine modelneoplasm/cancernoveloxidationoxidation reduction reactionpathwaypreservationprogramsprotein synthesisregeneraterespiratory mechanismresponserestricted dietsocial rolesuccesssynergismtumortumor cell metabolismtumor growthtumor metabolismtumorigenesisuptake

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Project Summary
To proliferate, cells must synthesize sufficient biomass, including nucleotides, proteins, and lipids. This
is particularly important for rapidly proliferating cancer cells, which reprogram metabolism to meet the increased
biosynthetic demands of proliferation. However, biosynthetic demands differ across cancer types and…

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Investigating how cancer cells maintain redox homeostasis to support biomass production — HARVARD MEDICAL SCHOOL | UNITE | Dev Procure