grant
Investigating epigenetic mechanisms of cancer
Organization UNIVERSITY OF FLORIDALocation GAINESVILLE, UNITED STATESPosted 1 Sept 2024Deadline 31 Aug 2029
NIHUS FederalResearch GrantFY2025Amino AcidsAssayAwardBioassayBiochemicalBiological AssayCRISPR editing screenCRISPR screenCRISPR-based screenCRISPR/Cas9 screenCancer CenterCancer InterventionCancer PatientCancer Research ProgramsCancer Research ProjectCancersCell BodyCellsCellular ExpansionCellular GrowthChromatinCollaborationsDNA AlterationDNA Sequence AlterationDNA mutationDependenceDrug resistanceEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessFloridaFundingGene ExpressionGene Expression MonitoringGene Expression Pattern AnalysisGene Expression ProfilingGeneralized GrowthGeneticGenetic AlterationGenetic ChangeGenetic defectGenetic mutationGlucocorticoid ReceptorGlucocorticoidsGlutamatesGrowthHDAC8HDAC8 geneHealthHepatic Neoplasm SecondaryHepatic metastasisHeterogeneityHistone Deacetylase 8Histone FoldHistone H2BImmuneImmunesIntraocular MelanomaInvestigatorsL-GlutamateL-LysineLeadLiver secondariesLiver secondary cancerLysineMalignant MelanomaMalignant NeoplasmsMalignant TumorMelanomaMetastasisMetastasizeMetastatic LesionMetastatic MassMetastatic NeoplasmMetastatic Neoplasm to the LiverMetastatic TumorMetastatic Tumor to the LiverMetastatic malignant neoplasm to liverMutationNeoplasm MetastasisOncogenesisPathogenesisPathway interactionsPatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPb elementPhenotypePropertyResearchResearch PersonnelResearch SupportResearchersResistanceSecondary NeoplasmSecondary TumorSequence AlterationSpecialistTechniquesTechnologyTissue GrowthTranscript Expression AnalysesTranscript Expression AnalysisUniversitiesUveal MelanomaWorkacute lymphoblastic leukemia cellacute lymphocytic leukemia cellacute lymphoid leukemia cellaminoacidanalyze gene expressionanti-cancer researchcancer metastasiscancer progressioncancer researchcareercell growthclustered regularly interspaced short palindromic repeats screendrug resistantdrug withdrawalepigeneticallyepigenomicsexperimentexperimental researchexperimental studyexperimentsgene expression analysisgene expression assaygenome mutationgenomic alterationglutamatergicheavy metal Pbheavy metal leadhistone H3 methyltransferasehistone methylasehistone methyltransferaseimprovedinhibitorliver metastasesmalignancymalignant liver neoplasm, specified as secondarymetastasis in the livermetastasis to the livermetastasize to the livermetastatic cancer to livermetastatic livermetastatic liver neoplasmmutantneoplasm progressionneoplasm/cancerneoplastic progressionontogenypathwaypatient oriented outcomesprogramsreceptor expressionresistance to Drugresistantresistant to Drugsecondary liver malignancysecondary malignant liver neoplasmsuccesstargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttranscriptional profilingtumor cell metastasistumor progressiontumorigenesisuvea melanoma
Description preview
Project Summary
Disruptions of epigenetic mechanisms that regulate gene expression are frequently found in cancer and
collaborate with genetic alterations to drive cancer phenotypes such as therapy resistance and immune escape.
Since 2016, Dr. Bennett, the research specialist for this R50 award application, has supervised teams of
researchers and…
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