grant
Intrinsic STING signaling shapes phagocytosis-dependent innate immunity
Organization OHIO STATE UNIVERSITYLocation Columbus, UNITED STATESPosted 19 Feb 2026Deadline 31 Jan 2031
NIHUS FederalResearch GrantFY2026AddressAffectAgonistAntigen-Presenting CellsApoptoticBacteriaCancer Causing AgentsCancer TreatmentCancersCarcinogensCell BodyCell Communication and SignalingCell NucleusCell Senescence InductionCell SignalingCellsCellular TransformationCellular injuryCheckpoint inhibitorChemicalsChemotactic CytokinesChemotherapy and RadiationChemotherapy and/or radiationCross PresentationCyclic GMPCyclicityCytoplasmCytosolDNADNA DamageDNA InjuryDNA NucleasesDNaseDataDefectDeoxyribonucleasesDeoxyribonucleic AcidDevelopmentDinucleoside PhosphatesDiseaseDisorderDouble-Stranded DNAEventExtravasationGene CombinationsGene ExpressionGene TranscriptionGenerationsGenesGenetic TranscriptionGuanosine Cyclic MonophosphateHomologous Chemotactic CytokinesHost DefenseHumanImmuneImmune SurveillanceImmune checkpoint inhibitorImmune mediated therapyImmune systemImmunesImmunologic SurveillanceImmunologically Directed TherapyImmunosurveillanceImmunotherapyImpairmentIn VitroInfectionInflammatoryInnate Immune ResponseInnate ImmunityIntercrinesIntracellular Communication and SignalingInvadedLaboratoriesLeadLeakageMalignantMalignant - descriptorMalignant CellMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMalignant NeoplasmsMalignant TumorMediatingMicrobeMitochondrial DNAModern ManNative ImmunityNatural ImmunityNon-Specific ImmunityNonspecific ImmunityNuclearNucleic AcidsNucleusOncogensPathway interactionsPb elementPeriodicityPhagocytesPhagocytic CellPhagocytosisPrediction of Response to TherapyProductionProteinsRNA ExpressionRadiationRadiation therapyRadiotherapeuticsRadiotherapyRefractoryRepressionResearchRhythmicitySIS cytokinesShapesSignal TransductionSignal Transduction SystemsSignalingSignaling Factor Proto-OncogeneSignaling Pathway GeneSignaling ProteinSpillageStimulator of Interferon GenesSystemT-CellsT-LymphocyteTransactivationTranscriptionTreatment outcomeTumor AntigensTumor CellTumor-Associated AntigenVesicleaccessory celladaptive immunityamebocyteanti-cancer therapyanti-tumor immune responsebiological signal transductioncGAMP STINGcGAMP-STINGcGAMP/STINGcGAS/STINGcGMPcancer antigenscancer cellcancer therapycancer-directed therapycarcinogenicitycell agecell damagecell injurycell transformationcellular agecellular aging inductioncellular damagecellular senescence inductionchemo/radiation therapychemoattractant cytokinechemokinechemotherapychemotherapy and radiotherapycyclic GMP-AMP synthase/STINGcytokinedamage to cellsdevelopmentaldinucleotideds-DNAdsDNAepigenetic gene silencingepigenetic silencingheavy metal Pbheavy metal leadimmune check point inhibitorimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based therapiesimmune-based treatmentsimmuno therapyimmunogenicimprovedin vivoinjury to cellsinsightmalignancymetaplastic cell transformationmicrobialmicrobial antigenmicronucleusmicroorganism antigenmtDNAneoplasm/cancerneoplastic cellnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovelnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachoncogenic agentpathwaypredict therapeutic responsepredict therapy responseradiation or chemotherapyradiation treatmentreconstitutereconstitutionresistance mechanismresistant mechanismsenescence inductiontherapy predictionthymus derived lymphocytetrans-activationtransformed cellstranslation strategytranslational approachtranslational strategytreatment predictiontreatment response predictiontreatment with radiationtumortumor-specific antigen
Description preview
ABSTRACT:
Our laboratory discovered and confirmed STING (Stimulator of Interferon Genes) as an
essential component of the cytosolic DNA-mediated innate immune response pathway. We
subsequently demonstrated that STING signaling is commonly suppressed in microbial infected
cells or human cancers, which enable such cells to escape the host…
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