🗂️
Archived grant — no longer open
This grant has closed and is kept as a historical reference. Browse current grants for active opportunities.
grant
Intraventricular Hemorrhage Disrupts the Blood Brain Barrier in Premature Infants
Organization ALBERT EINSTEIN COLLEGE OF MEDICINELocation BRONX, UNITED STATESPosted 1 Mar 2021Deadline 28 Feb 2026 ⚠️
NIHUS FederalResearch GrantFY20251,2,3-Propanetriol1,2,3-Trihydroxypropane21+ years oldAcquired brain injuryAdherens JunctionAdhering JunctionAdhesive JunctionAdultAdult HumanAffectAgonistAnchoring JunctionApoplexyAutopsyBBB disruptionBBB functionBBB permeabilizationBBB permeableBehavioralBindingBiologyBloodBlood - brain barrier anatomyBlood Reticuloendothelial SystemBlood TestsBlood capillariesBlood leukocyteBlood-Brain BarrierBrainBrain Hypoxia-IschemiaBrain InfarctionBrain InjuriesBrain Nervous SystemBrain Vascular AccidentBrain regionCapillary Endothelial CellCardiac ToxicityCardiotoxicCardiotoxicityCell BodyCell Communication and SignalingCell MaturationCell SignalingCellsCerebral PalsyCerebral StrokeCerebrovascular ApoplexyCerebrovascular StrokeCerebrumChaperoneChoroid PlexusCirculationCognitive deficitsComplicationCoupledDevelopmentDiseaseDisorderDisseminated SclerosisDomestic RabbitDrugsEdg ReceptorsEncephalonEndotheliumEngineeringEvaluationEventExudateFailureG Protein-Complex ReceptorG Protein-Coupled Receptor GenesG-Protein-Coupled ReceptorsG-ProteinsGPCRGTP-Binding ProteinsGTP-Regulatory ProteinsGene TranscriptionGenetic TranscriptionGlycerinGlycerolGuanine Nucleotide Coupling ProteinGuanine Nucleotide Regulatory ProteinsHedgehog (Hh) signal transduction pathwayHemato-Encephalic BarrierHematologic TestsHematological TestsHematology TestingHortega cellHumanHydrocephalusHydrocephalyImmuneImmune infiltratesImmune responseImmunesImmunityImmunosuppressionImmunosuppression EffectImmunosuppressive EffectInfantInfiltrationInflammationInflammatory ResponseInjuryInterventionIntracellular Communication and SignalingLeucocytic infiltrateLeukocytesLeukocytes Reticuloendothelial SystemLipid ALipidsLiquid substanceMR ImagingMR TomographyMRIMRIsMagnetic Resonance ImagingMarrow leukocyteMediatingMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMedicationMiceMice MammalsMicrogliaModelingModern ManMolecular ChaperonesMolecular InteractionMorphologyMultiple SclerosisMurineMusMyeloid CellsNMR ImagingNMR TomographyNervous System InjuriesNervous System PhysiologyNervous System TraumaNervous System damageNeurologicNeurologic functionNeurologicalNeurological DamageNeurological InjuryNeurological functionNeurological traumaNuclear Magnetic Resonance ImagingObstructionOccluding JunctionsOryctolagus cuniculusPathologicPathway interactionsPermeabilityPharmaceutical PreparationsPremature InfantProductionProgenitor CellsPublic HealthRNA ExpressionRabbitsRabbits MammalsReceptor ProteinReceptor SignalingRecoveryResearchRoleS1P ReceptorSCmRNAseqSHHSHH geneSamplingSignal TransductionSignal Transduction SystemsSignalingSingle cell mRNA seqSonic HedgehogSphingosine-1-Phosphate ReceptorStrokeStructure of choroid plexusSurvivorsTestingTight JunctionsTime StudyTracerTranscriptionVentricularWhite Blood CellsWhite CellZeugmatographyZonula Occludensadulthoodantagonismantagonistastrogliosisbiological signal transductionblood-brain barrier disruptionblood-brain barrier functionblood-brain barrier permeabilizationblood-brain barrier permeablebloodbrain barrierbloodbrain barrier disruptionbloodbrain barrier functionbloodbrain barrier permeabilizationbloodbrain barrier permeablebrain attackbrain damagebrain infarctbrain parenchymabrain-injuredcapillarycerebralcerebral vascular accidentcerebrovascular accidentcognitive defectscontrast enhanceddevelopmentaldrug/agenteffective therapyeffective treatmentfluidgitter cellglobal gene expressionglobal transcription profilehedgehog signalinghedgehog signaling pathwayhh signaling pathwayhost responsehydrocephalichypoxia/ischemiaimmune cell infiltrateimmune suppressionimmune suppressive activityimmune suppressive functionimmune system responseimmunoresponseimmunosuppressive activityimmunosuppressive functionimmunosuppressive responseinfants born prematureinfants born prematurelyinjuriesinsular sclerosisintraventricular hemorrhagelipid mediatorliquidmesogliamicroglial cellmicrogliocytemigrationmyelinationnecropsyneonatenervous system functionneurobehaviorneurobehavioralneuroprotectionneuroprotectiveneurotraumanew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyoligodendrocyte precursoroligodendrocyte precursor celloligodendrocyte progenitoroligodendrocyte stem cellpathwayperivascular glial cellpostmortemprematurepremature babypremature infant humanprematuritypreterm babypreterm infantpreterm infant humanpreventpreventingreceptorrestorationrhoshRNAshort hairpin RNAsingle cell mRNA sequencingsmall hairpin RNAsmoothened signaling pathwaysocial rolesphingosine 1-phosphatestem cellsstrokedstrokessubstantia albatargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttraffickingtranscriptometranscytosiswhite blood cellwhite blood corpusclewhite matterwhite matter injury
Applications closed.
Description preview
Abstract
Intraventricular hemorrhage (IVH) remains a major neurological complication of prematurity that results in
cerebral palsy, hydrocephalus, and cognitive deficits. No effective therapy exists to prevent these disorders in
infants with IVH. IVH triggers inflammation in the periventricular germinal matrix and adjacent white matter,
resulting…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click