grant
Intradialytic Myocardial Stunning in Hemodialysis Patients - a Novel Cardiovascular Risk Factor
Organization NEW YORK UNIVERSITY SCHOOL OF MEDICINELocation NEW YORK, UNITED STATESPosted 24 Dec 2021Deadline 30 Nov 2026
NIHUS FederalResearch GrantFY2026AcuteAddressAmericanArrhythmiaAttentionAutonomic DysfunctionAutonomic nervous systemBaroreceptor ReflexBaroreflexBiological MarkersBlood PlasmaBlood PressureCardiacCardiac ArrhythmiaCardiovascularCardiovascular Body SystemCardiovascular Organ SystemCardiovascular systemCaringCatecholaminesCessation of lifeCitiesComplicationDataDeathDeath RateDedicationsDevelopmentDialysisDialysis patientsDialysis procedureDysfunctionESKDESRDEchocardiogramEchocardiographyEnd stage renal failureEnd-Stage Kidney DiseaseEnd-Stage Renal DiseaseEndocrine Gland SecretionEpidemiologyEventExpenditureFunctional disorderFundingHealth Insurance for Aged and Disabled, Title 18Health Insurance for Disabled Title 18HeartHeart ArrhythmiasHeart VascularHeart failureHemodialysesHemodialysisHispanicHormonesImpairmentIncidenceIndividualIntervention TrialInterventional trialInvestigationIschemic HeartIschemic Heart DiseaseIschemic myocardiumKnowledgeLeadLeft Ventricular DysfunctionLeft Ventricular HypertrophyLevarterenolLevonorepinephrineLifeLinkMaintenanceMeasurementMeasuresMedicareModalityMonitorMorbidityMotionMulti-center studiesMulticenter StudiesMyocardialMyocardial IschemiaMyocardial StunningMyocardial depressionMyocardial dysfunctionNecrosisNecroticNerve CellsNerve UnitNervous System controlNeural CellNeurocyteNeurohormonesNeuronsNoradrenalineNorepinephrineOsmolar ConcentrationOsmolarityPETPET ScanPET imagingPETSCANPETTPathogenesisPathologicPatientsPatternPb elementPhenotypePhysiologyPhysiopathologyPlasmaPlasma SerumPopulationPositron Emission Tomography Medical ImagingPositron Emission Tomography ScanPositron-Emission TomographyPredispositionPrevalenceProceduresPublishingRad.-PETRecurrenceRecurrentReflexReflex actionResearch DesignReticuloendothelial System, Serum, PlasmaRisk FactorsRoleStressStress cardiomyopathyStudy TypeStunned MyocardiumSubgroupSusceptibilitySympathetic Nervous SystemSympathinsSyndromeTakotsuboTestingTimeTitle 18Toxic effectToxicitiesTransthoracic EchocardiographyUltrafiltrationUnited StatesVariantVariationWomanattributable deathattributable mortalityautonomic reflexbio-markersbiologic markerbiomarkerblack patientcardiac damagecardiac dysfunctioncardiac failurecardiac ischemiacardiovascular riskcardiovascular risk factorcirculatory systemcohortcoronary ischemiadesigndesigningdevelopmentaldialysis therapyepidemiologicepidemiologicalhealth insurance for disabledheart damageheart dysfunctionheart ischemiaheart sonographyheavy metal Pbheavy metal leadhemodynamicshigh riskhigh risk grouphigh risk individualhigh risk peoplehigh risk populationimprovedinnovateinnovationinnovativeinsightleft ventricle abnormalitymortalitymortality ratemyocardial damagemyocardial ischemia/hypoxiamyocardium ischemianeural imagingneuro-imagingneuroendocrine hormonesneurohormonalneuroimagingneurological imagingneuronalneurophysiologicalneurophysiologynew drug targetnew drug treatmentsnew druggable targetnew drugsnew pharmacological therapeuticnew pharmacotherapy targetnew therapeutic targetnew therapeuticsnew therapynew therapy targetnext generation therapeuticsnovelnovel drug targetnovel drug treatmentsnovel druggable targetnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel pharmacotherapy targetnovel therapeutic targetnovel therapeuticsnovel therapynovel therapy targetpathophysiologypatient subclasspatient subclusterpatient subgroupspatient subpopulationspatient subsetspatient subtypespositron emission tomographic (PET) imagingpositron emission tomographic imagingpositron emitting tomographypreventpreventingresponsesocial rolestress-induced cardiomyopathystudy designsudden cardiac deathtargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttrial design
Description preview
Project Summary
Despite rigorous investigations and the expenditure of nearly 6% of Medicare funds on their care, annual
mortality among the 511,000 dialysis patients in the United States is extraordinarily high. Approximately, 17%
of patients die annually with half of deaths attributable to cardiovascular (CV) causes, particularly sudden
cardiac…
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