grant
Intra-articular corticosteroid injections for symptomatic osteoarthritis: The effects of injection dose, frequency, and timing on safety
Organization WASHINGTON UNIVERSITYLocation SAINT LOUIS, UNITED STATESPosted 10 Sept 2025Deadline 31 Aug 2028
NIHUS FederalResearch GrantFY202521+ years oldAccelerationActive Follow-upAcuteAddressAdmissionAdmission activityAdrenal Cortex HormonesAdultAdult HumanAdverse ExperienceAdverse effectsAdverse eventAffectAgeAgingAnalgesic AgentsAnalgesic DrugsAnalgesic PreparationAnalgesicsAnodynesAntinociceptive AgentsAntinociceptive DrugsApoplexyArthritisArthroplastyAutoimmune DiseasesBlood GlucoseBlood PressureBlood SugarBone DensityBone Mineral DensityBrain Vascular AccidentCardiac DiseasesCardiac DisordersCardiovascularCardiovascular Body SystemCardiovascular DiseasesCardiovascular Organ SystemCardiovascular systemCaringCase SeriesCellulitisCerebral StrokeCerebrovascular ApoplexyCerebrovascular StrokeCharacteristicsChronic Kidney FailureChronic Renal DiseaseChronic Renal FailureClinical Practice GuidelineClinical ResearchClinical StudyCommunitiesComplexConsensusCorticoidsCorticosteroidsCoxarthrosisDataDegenerative ArthritisDegenerative polyarthritisDiabetes MellitusDoseDrugsEventExclusionExposure toExtended Care FacilitiesFracture due to osteoporosisFrequenciesGoalsHeart DiseasesHeart VascularHerpes ZosterHerpes zoster diseaseHip OsteoarthritisHistoryHospital AdmissionHospitalizationHyperglycemiaHypertensionImmune responseImmunosuppressionImmunosuppression EffectImmunosuppressive EffectImpairmentIncidenceIndividualInfectionInjectionsInterventionIntravenousJoint Prosthesis ImplantationJointsKnee OsteoarthritisKnowledgeLifeMedicalMedicare claimMedicationMethodologyMethodsNursing HomesOperative ProceduresOperative Surgical ProceduresOralOsteoarthritisOsteoarthrosisOsteoporosisOsteoporosis with fractureOsteoporotic fractureOut-patientsOutcomeOutpatientsPainPain ControlPain TherapyPain managementPainfulPatientsPatternPharmaceutical PreparationsPhysiciansPneumoniaPopulationProceduresProviderQOLQuality of lifeRandomization trialRecommendationRecording of previous eventsReplacement ArthroplastyReportingResearchRiskSafetySample SizeScientistShinglesShoulderSiteSkilled Nursing FacilitiesStrokeSubgroupSurgicalSurgical InterventionsSurgical ProcedureTimeUncertaintyUrinary tract infectionUrinary tract infectious diseaseVascular Hypertensive DiseaseVascular Hypertensive DisorderZonaZosterabsorptionactive followupadulthoodadverse consequenceadverse event riskadverse outcomeagesarthriticautoimmune conditionautoimmune disorderautoimmunity diseasebrain attackcardiovascular disordercerebral vascular accidentcerebrovascular accidentchronic kidney diseasecirculatory systemclinical decision-makingclinical practice and guidelinesco-morbidco-morbiditycomorbiditydegenerative joint diseasedesigndesigningdiabetesdisabilitydoubtdrug/agentevidence basefallsfollow upfollow-upfollowed upfollowupfrailtyfunctional improvementheart disorderherpes zonahigh blood pressurehigh riskhip OAhistorieshost responsehyperglycemichyperpiesiahyperpiesishypertensive diseasehypertensive disorderhypertrophic arthritisimmune suppressionimmune suppressive activityimmune suppressive functionimmune system responseimmunoresponseimmunosuppressive activityimmunosuppressive functionimmunosuppressive responseimprove functionimproved functional outcomesinfection riskjoint arthroplastyjoint replacementknee OAknee joint OAknee joint osteoarthritisnursing homeold ageolder adultolder adulthoodosteoporosis associated fractureosteoporosis related fractureosteoporosis with pathological fracturepain interventionpain killerpain medicationpain reductionpain relieverpain treatmentpainkillerprescription analgesicprescription pain medicationprescription pain relieverpreventpreventingrandomized trialreduce painsexshared decision makingstrokedstrokessurgerysymptom treatmentsymptomatic treatmenttime intervaltreat symptomtreatment guidelinesurinary infection
Description preview
PROJECT SUMMARY / ABSTRACT
Osteoarthritis (OA) is the most common type of arthritis and a frequent cause of pain and disability.
Osteoarthritis annually affects ~595 million adults globally, with anticipated rises in incidence due to aging of
the population. Treatment guidelines for symptomatic OA of the knee, hip, and shoulder recommend non-…
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