grant
Intestinal Epithelial Heat Shock Protein 25/27 integrates host immune and microbial drivers required for mucosal restitution following inflammatory injury of the gut
Organization UNIVERSITY OF CHICAGOLocation CHICAGO, UNITED STATESPosted 2 Feb 2026Deadline 30 Nov 2029
NIHUS FederalResearch GrantFY2026AblationActin FilamentsActinsAddressAdhesion PlaquesAffectAreaAssayAutoregulationB cell differentiation factorB cell stimulating factor 2B-Cell Differentiation FactorB-Cell Differentiation Factor-2B-Cell Stimulatory Factor-2BCDFBSF-2BSF2BindingBioassayBiological AssayBleedingBody TissuesCSAID-Binding Protein 1CSAID-Binding Protein 2CSBP2Cell BodyCell Communication and SignalingCell DifferentiationCell Differentiation processCell Growth in NumberCell LocomotionCell MaturationCell MigrationCell MovementCell MultiplicationCell ProliferationCell SignalingCell-Matrix Adherens JunctionsCellsCellular ExpansionCellular GrowthCellular MigrationCellular MotilityCellular ProliferationChromatinChronicClinicalColitisColonColon InjuryColorectal CancerCommunicable DiseasesComplexCytochalasin DCytokine-Suppressive Antiinflammatory Drug-Binding Protein 1Cytokine-Suppressive Antiinflammatory Drug-Binding protein 2DSS colitisDSS modelDSS mouse modelDSS-induced acute colitisDSS-induced colitisDataDiseaseDisease remissionDisorderDrug TherapyElementsEngraftmentEnsureEpithelial Cell ProliferationEpithelial CellsEventExhibitsFibrosisFilamentFocal AdhesionsFocal ContactsGene ExpressionGene TargetingGene TranscriptionGenesGeneticGenetic TranscriptionGerm-FreeGut MucosaHPGFHeat shock proteinsHemorrhageHepatocyte-Stimulating FactorHomeostasisHumanHybridoma Growth FactorIFN-beta 2IFNB2IL-22IL-6IL6 ProteinImmuneImmunesImpairmentIn VitroInfectionInfectious DiseasesInfectious DisorderInflammationInflammatoryInflammatory Bowel DiseasesInflammatory Bowel DisorderInjuryInterleukin-6IntestinalIntestinal MucosaIntestinesIntracellular Communication and SignalingIschemic ColitisKnowledgeLabelMAPK14MAPK14 Mitogen-Activated Protein KinaseMAPK14 geneMGI-2MechanicsMediatingMediatorMiceMice MammalsMicrofilamentsMitogen-Activated Protein Kinase 14ModelingModern ManMolecularMolecular InteractionMolecular WeightMucosaMucosal InflammationMucosal TissueMucositisMucous MembraneMurineMusMxi2Myeloid Differentiation-Inducing ProteinMyofilamentsNuclearOccluding JunctionsOrganoidsOutcomePathway interactionsPatient CarePatient Care DeliveryPharmacological TreatmentPharmacotherapyPhasePhysiologicPhysiologicalPhysiological HomeostasisPlasmacytoma Growth FactorPolymersProcessProliferatingRNA ExpressionRNA SeqRNA sequencingRNAseqRadiationRecoveryRegulationRemissionRiskRoleSAPK2ASTAT3STAT3 geneSignal TransductionSignal Transduction SystemsSignalingSmall IntestinesSodium Dextran SulfateStressStress-Activated Protein Kinase 2ATNBS colitisTNBS miceTNBS modelTNBS mouse modelTNBS-induced colitisTestingTight JunctionsTissuesTranscriptionWound RepairZonula Occludensbasebasesbiological signal transductionblood lossbowelcare for patientscare of patientscaring for patientscell growthcell motilitycellular differentiationchronic inflammatory diseasecolitis-induced dysbiosiscolon microbescolon microbial communitycolon microbiotacolonic microbiotacytokinedesigndesigningdextran sulfate sodium colitisdextran sulfate sodium induced colitisdextran sulfate sodium modeldextran sulfate sodium mouse modeldirectional celldirectional cellsdisease phenotypedrug discoverydrug interventiondrug treatmentfunctional outcomeshealingin vivoin vivo Modelinflammatory disease of the intestineinflammatory disorder of the intestineinjuredinjuriesinjury to the intestinesinsightinterferon beta 2interleukin-22intestinal autoinflammationintestinal epitheliumintestinal injurymechanicmechanicalmicrobialmicrobial consortiamicrobial floramicrobiotamicrofloramonolayermouse modelmucosa-associated microbesmucosa-associated microbial communitymucosa-associated microbiotamucosal floramucosal microbesmucosal microbiotamucosal microfloramultispecies consortiamurine modelnovelp38p38 MAP Kinasep38 MAPK Genep38 Mitogen Activated Protein Kinasep38 Protein Kinasep38 SAPKp38-Alphap38Alphapathwaypharmaceutical interventionpharmacologicpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticspolymerpolymericpolymerizationprogramspromoterpromotorrepairrepairedresponsesmall bowelsocial rolestress proteintranscriptome sequencingtranscriptomic sequencingtrinitrobenzene sulfonic acid colitistrinitrobenzene sulfonic acid induced colitistrinitrobenzene sulfonic acid induced mouse modeltrinitrobenzene sulfonic acid modeltrinitrobenzene sulfonic acid mouse modelvigilancewound healingwound recoverywound resolution
Get Agency plan to apply$29.99/mo · 7-day free trial · pipeline · alerts
or
— or —Get email alerts for similar roles
Description preview
Project Summary/Abstract
Mucosal healing is an essential physiological response to inflammatory and injurious diseases of the bowel,
including ischemic colitis, radiation-induced mucosal injury, and inflammatory bowel diseases (IBD). In fact,
successful and complete mucosal healing in IBD is associated with better clinical outcomes, longer…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click