grant
Intersecting clinical, genomic, and experimental investigation to understand the mechanisms and impact of coronary artery patterning
Organization PALO ALTO VETERANS INSTIT FOR RESEARCHLocation PALO ALTO, UNITED STATESPosted 1 Aug 2024Deadline 31 Jul 2028
NIHUS FederalResearch GrantFY202521+ years oldAdultAdult HumanAfricanAnatomic SitesAnatomic structuresAnatomyAngioplastyAortaArteriesAssayAwarenessBioassayBiologicalBiological AssayBypassCXCL12CXCL12 geneCXCL12 proteinCandidate Disease GeneCandidate GeneCardiac arteryCardiologyCardiovascularCardiovascular Body SystemCardiovascular DiseasesCardiovascular Organ SystemCardiovascular systemCatheterizationCause of DeathCellular biologyChemokine (C-X-C Motif) Ligand 12ClassificationClinicalComplementary interventionComplementary therapiesComplementary treatmentCoronaryCoronary AngiographyCoronary ArteriosclerosisCoronary Artery DiseaseCoronary Artery DisorderCoronary AtherosclerosisCoronary Vessel AnomaliesCoronary abnormalitiesCoronary anomaliesCoronary arteryCoronary artery dysfunctionCoronary dysfunctionDNA TherapyDataData SetDeveloping fetusDevelopmentDiseaseDisorderDrug TherapyDrugsEHR systemEmbryo and Fetal DevelopmentEmbryonic and Fetal DevelopmentEpidemiologyEuropeanFetal DevelopmentFoundationsGWA studyGWASGene Transfer ClinicalGene variantGeneralized GrowthGenesGeneticGenetic DeterminismGenetic InterventionGenetic PolymorphismGenetic studyGenomicsGoalsGrowthHealth Care SystemsHeart InjuriesHeart VascularHeart arteryHeritabilityHispanic AmericansHumanHuman GeneticsIndividualInjuryIntegrated Health Care SystemsInterventionInvestigationInvestmentsKnowledgeLeftLifeMapsMechanicsMedicalMedicationMedicineMeta-AnalysisMethodsModelingModern ManMolecularNatural Language ProcessingNatural regenerationOperative ProceduresOperative Surgical ProceduresOutcomePBSFParticipantPathway interactionsPatientsPatternPharmaceutical PreparationsPharmacological TreatmentPharmacotherapyPhenotypePopulation GeneticsPopulation HeterogeneityPre-B Cell Growth Stimulating FactorPredisposition geneProceduresPropertyRegenerationRegenerative pathwayRegistriesResearchRiskSCYB12SDF-1SDF-1ASDF-1BSDF-1alphaSDF1SDF1ASDF1BSdf1 proteinSeriesStromal Cell-Derived Factor 1SurgicalSurgical InterventionsSurgical ProcedureSusceptibility GeneSystematicsTLSF-ATLSF-BTPAR1TestingTissue GrowthTranslational ResearchTranslational ScienceUnited StatesVariantVariationVeteransVeterans Health AdministrationVeterans Health AffairsWorkacute coronary syndromeadulthoodadvanced diseaseadvanced illnessallelic variantatherosclerotic coronary diseasebiobankbiologicbiorepositorycardiac injurycardiovascular disordercausal allelecausal genecausal mutationcausal variantcausative mutationcausative variantcell biologycirculatory systemcoronary arterial diseasecoronary artery abnormalitiescoronary artery anomaliesdesigndesigningdevelopmentaldiverse populationsdrug interventiondrug treatmentdrug/agentelectronic health record systemepidemiologicepidemiologicalepigenetic biomarkerepigenetic markergene locusgene manipulationgene repair therapygene therapygene-based therapygenetic determinantgenetic epidemiologic studygenetic epidemiologygenetic locusgenetic manipulationgenetic therapygenetic variantgenetically manipulategenetically perturbgenome wide associationgenome wide association scangenome wide association studygenomewide association scangenomewide association studygenomic locationgenomic locusgenomic therapygenomic varianthIRHheterogeneous populationhiPSChuman iPShuman iPSChuman induced pluripotent cellhuman induced pluripotent stem cellshuman inducible pluripotent stem cellshuman inducible stem cellshuman population geneticshuman population studyimprovedinduced human pluripotent stem cellsinjuriesinnovateinnovationinnovativeintegrated health systemintegrated system of careintraluminal angioplastymechanicmechanicalmortalitymouse geneticsmultidisciplinarynatural language understandingnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyontogenypathwaypharmaceutical interventionpharmacologicpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticspolymorphismpopulation diversitypre-clinicalpreclinicalpredisposing geneprogramsregenerateregeneration pathwayregenerative cellrevascularizationstatisticsstromal cell-derived factor-1alphastructural mutationstructural variantstructural variationsuccesssurgerysusceptibility allelesusceptibility locussusceptibility varianttranslation researchtranslational investigationwhole genome association analysiswhole genome association study
Description preview
PROJECT SUMMARY/ABSTRACT
Coronary artery disease (CAD) remains a leading cause of death despite the availability of lifesaving pharma-
cological and mechanical interventions. Complementary treatments are desperately needed, particularly for
individuals with advanced disease. Here, we propose foundational work toward realizing a hypothetical `medi-…
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