grant
Interrogation of Genetic Dependencies in Renal Cell Carcinomas.
Organization DIVISION OF BASIC SCIENCES - NCILocation UNITED STATES
NIHUS FederalResearch GrantFY2025Abnormal Assessment of MetabolismCRISPRCRISPR editing screenCRISPR screenCRISPR-based screenCRISPR/Cas systemCRISPR/Cas9 screenCancersCell BodyCell LineCellLineCellsCharacteristicsClinicalClustered Regularly Interspaced Short Palindromic RepeatsDNA mutationDependenceGenesGeneticGenetic ChangeGenetic PredispositionGenetic Predisposition to DiseaseGenetic ScreeningGenetic SusceptibilityGenetic defectGenetic mutationGenetic propensityGenomic approachGoalsGrawitz TumorHistologicHistologicallyHypernephroid CarcinomaHypernephromaInherited PredispositionInherited SusceptibilityIntermediary MetabolismKidney CancerKidney CarcinomaKnock-outKnockoutLibrariesMalignant NeoplasmsMalignant TumorMetabolicMetabolic ProcessesMetabolic StudiesMetabolismMetabolism StudiesModelingMolecularMolecular TargetMutationNephroid CarcinomaOutcomePatientsRenal AdenocarcinomaRenal CancerRenal CarcinomaRenal Cell AdenocarcinomaRenal Cell CancerRenal Cell CarcinomaResearchStrains Cell LinesTherapeutic InterventionValidationcancer typeclustered regularly interspaced short palindromic repeats screencombinatorialcultured cell linefitnessfunctional genomicsgenetic etiologygenetic mechanism of diseasegenetic vulnerabilitygenetically predisposedgenome editinggenome mutationgenome scalegenome-widegenomewidegenomic editinggenomic effortgenomic strategyimprovedintervention therapykidney adenocarcinomamalignancymetabolic abnormality assessmentneoplasm/cancernucleaseprogramsscreeningscreeningssmall molecular inhibitorsmall molecule inhibitortherapeutic targetvalidations
Description preview
We have established a Cas9-Cas12a CHyMErA-based combinatorial CRISPR screening platform in patient-derived renal cell carcinoma (RCC) cell lines and confirmed robust nuclease expression and genome editing efficiency. Leveraging a genome-wide CRISPR knockout library, we conducted systematic screens across diverse environmental and genetic RCC…
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