grant
Interrogating the Fgl2-FcgRIIB axis: A novel mechanism mediating apoptosis of tumor-specific memory CD8+ T cells
NIHUS FederalResearch GrantFY2025(TNF)-αAmericanAntitumor ResponseApopainApoptosisApoptosis PathwayApoptosis-Related Cysteine Protease Caspase 3Autocrine SystemsAutoregulationBindingBlood Coagulation Factor IBlood Coagulation Factor OneBlood Factor OneCASP-3CASP3CASP3 geneCD8 CellCD8 T cellsCD8 lymphocyteCD8+ T cellCD8+ T-LymphocyteCD8-Positive LymphocytesCD8-Positive T-LymphocytesCPP-32CPP32CPP32 proteinCPP32BCPP32betaCachectinCancer PatientCancersCell BodyCell Communication and SignalingCell IsolationCell SegregationCell SeparationCell Separation TechnologyCell SignalingCell SurvivalCell ViabilityCell secretionCellsCellular SecretionCharacteristicsCoagulation Factor ICoagulation Factor OneCutaneous MelanomaCysteine Protease CPP32Cysteine Protease CPP32 GeneCytoplasmic DomainCytoplasmic TailDataDiagnosisDiseaseDisorderExhibitsFOXP3FOXP3 geneFactor IFactor OneFc ReceptorFibrinogenFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryForkhead Box P3FutureGene set enrichment analysisGoalsGrantHematopoieticHomeostasisHumanIFN-GammaIFN-gIFN-γIFNGIFNγITIMImmuneImmune InterferonImmune mediated therapyImmune responseImmunesImmunityImmunologically Directed TherapyImmunoreceptor Tyrosine-Based Inhibitory MotifImmunosuppressionImmunosuppression EffectImmunosuppressive EffectImmunotherapeutic agentImmunotherapyInduction of ApoptosisInfiltrationInflammatoryInstitutionInterferon GammaInterferon Type IIIntracellular Communication and SignalingInvestigationJM2Knock-outKnockoutLabelLigand BindingLigandsMHC ReceptorMacrophage-Derived TNFMajor Histocompatibility Complex ReceptorMalignant Cutaneous MelanomaMalignant MelanomaMalignant Melanoma of SkinMalignant NeoplasmsMalignant Skin NeoplasmMalignant TumorMediatingMelanomaMelanoma SkinMelanoma TumorMelanoma patientMemoryMiceMice MammalsModelingModern ManMolecularMolecular InteractionMonocyte-Derived TNFMurineMusNon-Polyadenylated RNAPARP Cleavage ProteasePARP Cleavage Protease GenePD 1PD-1PD1Pathway interactionsPatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPatientsPeptidesPhenotypePhysiological HomeostasisPopulationPostdocPostdoctoral FellowProductionPrognostic MarkerProgrammed Cell DeathProtein SecretionProteinsProteomicsPublicationsRNARNA Gene ProductsReceptor ProteinRegulationRegulatory T-LymphocyteResearchResearch AssociateResistanceRibonucleic AcidRoleSCA-1SCA-1 GeneSCURFINSREBP Cleavage Activity 1SREBP Cleavage Activity 1 GeneSamplingScientific PublicationSignal TransductionSignal Transduction SystemsSignalingSkinSkin CancerSourceSurfaceT cell responseT-Cell Antigen ReceptorsT-Cell ReceptorT-CellsT-LymphocyteT8 CellsT8 LymphocytesTNFTNF ATNF AlphaTNF geneTNF-αTNFATNFαTransgenic MiceTransgenic OrganismsTransmissionTregTumor Necrosis FactorTumor Necrosis Factor-alphaTumor growth in melanomaWorkYamaYama proteinanti-cancer immunotherapyanti-tumor responseantibody receptoranticancer immunotherapyautocrinebiological signal transductioncancer immunotherapycancer infiltrating T cellscancer microenvironmentcaspase-3cell sortingcell typecysteine protease P32cytokinecytotoxic CD8 T cellscytotoxic CD8 T lymphocytedermal melanomaexhaustfightingflow cytophotometryhemopoietichost responseimmune drugsimmune suppressionimmune suppressive activityimmune suppressive functionimmune system responseimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based cancer therapiesimmune-based therapeuticsimmune-based therapiesimmune-based treatmentsimmuno therapyimmunologic therapeuticsimmunoresponseimmunosuppressive activityimmunosuppressive functionimmunosuppressive responseimmunotherapeuticsimmunotherapy agentimmunotherapy for cancerimmunotherapy of cancerimprovedlFN-Gammamalignancymalignant skin tumormelanoma cancer modelmelanoma modelmelanoma tumor modelmouse modelmultiomicsmultiple omicsmurine modelneoplasm/cancernovelpanomicspathwaypatient oriented outcomespatient responsepatient specific responsepatients suffering from melanomapatients with melanomapost-docpost-doctoralpost-doctoral traineeprognostic biomarkerprognostic indicatorprogrammed cell death 1programmed cell death protein 1programmed death 1receptorreceptor bindingreceptor boundrecruitregulatory T-cellsresearch associatesresistance mechanismresistantresistant mechanismresponseresponse biomarkerresponse markersresponsive patientscRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsle2social rolesuccesssystemic lupus erythematosus susceptibility 2therapeutic targetthymus derived lymphocytetranscriptomicstransgenictransmission processtumortumor infiltrating T cellstumor microenvironment
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PROJECT SUMMARY
One in fifty Americans will be diagnosed with melanoma in their lifetime and skin cutaneous melanoma is the
deadliest skin cancer. Cancer immunotherapy is a breakthrough approach to treat this disease and cytotoxic
CD8+ T-cell tumor infiltration is a critical factor to immunotherapeutic success. As such, identifying effective…
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