grant
Interplay of tumor genomic and immune characteristics and external drivers of health to improve cancer health outcomes
Organization UNIVERSITY OF CALIFORNIA, SAN FRANCISCOLocation SAN FRANCISCO, UNITED STATESPosted 1 Aug 2025Deadline 31 Jul 2030
NIHUS FederalResearch GrantFY2025AdvocateAnaplastic (Malignant) MeningiomaAnaplastic MeningiomaAutomobile DrivingBenignBiochemicalBioinformaticsBiologicalBiologyBiometricsBiometryBiostatisticsBlackBlack PopulationsBlack groupBlack individualBlack peopleBlack raceBlacksBrainBrain Nervous SystemBreast CancerBreast Cancer PatientBreast Cancer therapyBreast Tumor PatientCancer CenterCancer ControlCancer Control ScienceCancerousCancersCharacteristicsClinicalClinical ResearchClinical StudyCollaborationsCommunitiesCommunity OutreachComplexDevelopmentDiseaseDisorderEncephalonEnsureEnvironmental FactorEnvironmental Risk FactorEpidemiological dataEpidemiologyEpidemiology dataExcess MortalityFosteringGene variantGeneticGenomicsGerm LinesGoalsGrantHealthHumanImmuneImmune responseImmunesIncidenceIndividualInflammationInflammatoryInstitutionInvestigatorsInvestmentsKnowledgeLife StyleLifestyleLived experienceLived experiencesMalignant Breast NeoplasmMalignant MeningiomasMalignant NeoplasmsMalignant TumorMalignant neoplasm of prostateMalignant prostatic tumorMediatingModelingModern ManNeighborhoodsOperative ProceduresOperative Surgical ProceduresOutcomePathologyPathway interactionsPatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPatientsPersonsPlayPopulationPre-Clinical ModelPreclinical ModelsPrimary Brain NeoplasmsPrimary Brain TumorsProstate CAProstate CancerProstate malignancyProstatic ParenchymaProstatic TissueQualifyingR-Series Research ProjectsR01 MechanismR01 ProgramResearchResearch GrantsResearch PersonnelResearch Project GrantsResearch ProjectsResearch ResourcesResearchersResource SharingResourcesRisk FactorsSample SizeSamplingScientistStressSurgeonSurgicalSurgical InterventionsSurgical ProcedureTechniquesTissue BanksTissue CollectionTissue repositoryTranslatingTranslational ResearchTranslational ScienceTreatment outcomeTumor BiologyWorkallelic variantanti-cancer researchbiologicblack patientcancer researchcancer typecareercommunity advisory boardcommunity advisory committeecommunity advisory panelcommunity engagementdevelopmentaldifferences in healthdrivingengagement with communitiesenvironmental riskepidemiologicepidemiologic dataepidemiologicalexperiencegenetic variantgenomic varianthealth differencehigh riskhost responseimmune microenvironmentimmune system responseimmunoresponseimmunosuppressive microenvironmentimmunosuppressive tumor microenvironmentimprovedindividuals with breast cancerinsightinterestmalignancymalignant breast tumormembermeningiomamultidisciplinaryneoplasm/cancernovelpathwaypatient oriented outcomespatient populationpatients with breast cancerperson with breast cancerpoor health outcomepredict responsivenesspredicting responsepredictive biological markerpredictive biomarkerspredictive markerpredictive molecular biomarkerprogramsreduced health outcomeresponsesocialsurgerytooltranslation researchtranslational investigationtumortumor immune microenvironmenttumor-immune system interactionsworse health outcome
Description preview
The overall goal of the UCSF SPORE is to improve cancer health outcomes by investigating the interplay of genomic and immune characteristics with individual risk factors and external drivers of health. Three cancers (meningioma, prostate cancer and breast cancer) with well-known differences related to clinical outcomes, will be studied. At the…
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