grant
Interaction between nuclear epigenetic and metabolic pathways in cancer
Organization UNIVERSITY OF PENNSYLVANIALocation PHILADELPHIA, UNITED STATESPosted 1 Sept 2022Deadline 31 Aug 2029
NIHUS FederalResearch GrantFY2025Antioncogene Protein p53AreaBasal Transcription FactorBasal transcription factor genesBiologyCancer BiologyCancer CauseCancer EtiologyCancer GenesCancer ModelCancer cell lineCancer-Promoting GeneCancerModelCancersCellular Tumor Antigen P53ChromatinClinicCommunicationDNADeoxyribonucleic AcidDevelopmentDiseaseDisorderEnhancersEnzyme GeneEnzymesEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessFunding MechanismsFutureGene ExpressionGene TargetingGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGenomicsHistonesHistoryIntermediary MetabolismLinkMalignant NeoplasmsMalignant TumorMembraneMetabolicMetabolic PathwayMetabolic ProcessesMetabolismNormal CellNuclearOncogenesOncogenicOncoprotein p53P53Pathway interactionsPhosphoprotein P53Phosphoprotein pp53ProductionProtein TP53ProteomicsPublishingRecording of previous eventsRegulatory ElementResearchRoleTP53TP53 geneTRP53Transcription Factor Proto-OncogeneTranscription factor genesTransforming GenesTumor Protein p53Tumor Protein p53 GeneTumor Suppressor ProteinsWorkanti-cancer immunotherapyanticancer immunotherapycancer immunotherapycofactordevelopmentalepigenetic regulationepigeneticallyfascinatehistoriesimmune-based cancer therapiesimmunotherapy for cancerimmunotherapy of cancerindividual heterogeneityindividual variabilityindividual variationinfancyinfantileinhibitorinsightmalignancymembrane structuremouse modelmultidisciplinarymurine modelmutantneoplasm/cancernovelp53 Antigenp53 Genesp53 Tumor Suppressorpathwaypatient populationpatient responsepatient specific responsepharmacologicprogramsprotein p53refractory cancerresistant cancerresponsive patientsmall molecule therapeuticssocial roletargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttranscription factortumortumor suppressor
Description preview
Abstract
Despite
cancer
impressive strides in conventional small molecule therapeutics and novel cancer immunotherapies,
continues to be a devastating disease. Certain cancers are refractory to available therapies, and
patients' responses show large individual variability. Cancer involves striking dysregulation of epigenetic
pathways, with…
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