grant
Integrative approaches to elucidate p53 transcriptional networks during carcinogenesis
Organization STANFORD UNIVERSITYLocation STANFORD, UNITED STATESPosted 14 Aug 2015Deadline 31 Jul 2029
NIHUS FederalResearch GrantFY2025AcuteAffectAlternate SplicingAlternative RNA SplicingAlternative SplicingAlveolarAnti-OncogenesAntioncogene Protein p53AntioncogenesAssayBioassayBiological AssayCRISPR editing screenCRISPR screenCRISPR-based screenCRISPR/Cas9 screenCancer InductionCancer Suppressor GenesCancer TreatmentCancersCell BodyCell DifferentiationCell Differentiation processCell Growth in NumberCell MultiplicationCell ProliferationCellsCellular ProliferationCellular Tumor Antigen P53DNA DamageDNA InjuryDiseaseDisorderEarly DiagnosisEarly treatmentEmerogenesEventEvolutionGene TranscriptionGenesGenetic TranscriptionGoalsHepatocarcinomaHepatocellular CarcinomaHepatocellular cancerHepatomaHumanIndividualKRAS(G12D)KRASG12DKineticsLiver Cells CarcinomaLung AdenocarcinomaLung damageLung tissue regenerationMalignant CellMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMalignant NeoplasmsMalignant TumorMediatingMiceMice MammalsModern ManMolecularMolecular Tumor SuppressionMurineMusMutant Strains MiceMutateOnco-Suppressor GenesOncogenes-Tumor SuppressorsOncoprotein p53P53Pathway interactionsPhosphoprotein P53Phosphoprotein pp53PlayPrimary carcinoma of the liver cellsProtein TP53ProteomeProteomicsRNA ExpressionRNA SplicingRNA-Binding ProteinsRecessive OncogenesResearchRoleSplicingTP53TP53 geneTRP53TestingTherapeuticTranscriptionTranscriptional Activation DomainTuba-seqTumor Protein p53Tumor Protein p53 GeneTumor Suppressing GenesTumor SuppressionTumor Suppressor GenesTumor Suppressor ProteinsWorkZinc Finger DomainZinc Finger MotifsZinc Fingersanti-cancer therapycancer cellcancer microenvironmentcancer therapycancer-directed therapycarcinogenesiscellular differentiationclustered regularly interspaced short palindromic repeats screenearly detectionearly therapyimprovedin vivoinsightliver carcinomalung injurylung regenerationmalignancymouse modelmouse mutantmurine modelneoplasm/cancernoveloncosuppressor genep53 Antigenp53 Genesp53 Tumor Suppressorpathwayposttranscriptionalprogramsprotein p53pulmonary damagepulmonary injurypulmonary regenerationpulmonary tissue damagepulmonary tissue injuryresponsescATAC sequencingscATAC-seqscRNA sequencingscRNA-seqshRNAshort hairpin RNAsingle cell ATAC-seqsingle cell ATAC-sequencingsingle cell Assay for Transposase Accessible Chromatin sequencingsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell sequencing assay for transposase accessible chromatinsingle cell transcriptomic profilingsingle-cell Assay for Transposase-Accessible Chromatin with sequencingsingle-cell RNA sequencingsingle-cell assay for transposase-accessible chromatin using sequencingsingle-cell assay for transposase-accessible chromatin-seqsmall hairpin RNAsocial rolestandard of caretargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttumortumor barcoding and sequencingtumor microenvironmenttumor suppressor
Description preview
PROJECT SUMMARY/ABSTRACT
The TP53 tumor suppressor gene is mutated in over half of all human cancers, but the mechanisms through
which p53 suppresses cancer in vivo remain incompletely understood. Notably, there are no standard-of-care
cancer therapies based on the p53 pathway. In this proposal, we strive to deconstruct the pathways through
which…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click