grant
Integrated therapies for alcohol use and ALD (ITAALD) Network - IU Clinical Center
Organization INDIANA UNIVERSITY INDIANAPOLISLocation INDIANAPOLIS, UNITED STATESPosted 15 Sept 2012Deadline 30 Jun 2029
NIHUS FederalResearch GrantFY20251, 2-DehydrocortisoneAddressAffectAlcohol DrinkingAlcohol associated hepatitisAlcohol consumptionAlcohol hepatitisAlcohol induced hepatitisAlcohol related hepatitisAlcoholic HepatitisAlcoholic Liver DiseasesAncillary StudyAntimicrobial EffectAntioxidantsApoptoticBehavior Conditioning TherapyBehavior ModificationBehavior TherapyBehavior TreatmentBehavioral Conditioning TherapyBehavioral ModificationBehavioral TherapyBehavioral TreatmentBiological Specimen BanksBiological Substance BanksCare GiversCaregiversChimera ProteinChimeric ProteinsClinicalClinical TreatmentClinical TrialsCollectionCombined Modality TherapyCompensationConditioning TherapyCounselingDataData BanksData BasesDatabanksDatabasesDehydrocortisoneDelta(1)-CortisoneDeltacortisoneDeltadehydrocortisoneDiagnosisDrug TherapyEligibilityEligibility DeterminationEtOH drinkingEtOH useEthanol-induced hepatitisEvaluationFDA approvedFundingFusion ProteinGlucocorticoidsGuidelinesHealth Care ProvidersHealth PersonnelHeavy DrinkingHepatic DisorderHepatitisHospitalsIL-1 ReceptorsIL-1raIL-22IL1 ReceptorsIL1 febrile inhibitorIL1RNIndividualInformaticsInterleukin-1 Receptor AntagonistInterleukin-1 ReceptorsInvestigatorsKnowledgeLinkLiverLiver diseasesMeasuresMetacortandracinMorbidityMorbidity - disease rateMultimodal TherapyMultimodal TreatmentN-acetylhomotaurineNIAAANational Institute on Alcohol Abuse and AlcoholismObservation researchObservation studyObservational StudyObservational researchOutcomePatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPatientsPharmacological TreatmentPharmacotherapyPhasePhysiciansPrednisonePrednisonumProtocol ScreeningQOCQOLQuality of CareQuality of lifeRandomizedRandomized, Controlled TrialsRegression AnalysesRegression AnalysisRegression DiagnosticsReportingResearch DesignResearch PersonnelResearch ResourcesResearchersResourcesSafetySiteStatistical RegressionSteroid CompoundSteroidsStudy TypeSystems BiologyTranslational ResearchTranslational ScienceTransplantationZincZn elementabstaining from alcoholabstaining from ethanolabstinence from alcoholabstinence from ethanolacamprosateacamprostatealcohol abstinencealcohol abuse therapyalcohol abuse treatmentalcohol induced hepatic injuryalcohol induced liver disorderalcohol induced liver injuryalcohol ingestionalcohol intakealcohol misusealcohol product usealcohol related liver diseasealcohol treatmentalcohol usealcohol use disorderalcohol-associated liver diseasealcohol-induced hepatic dysfunctionalcohol-induced liver diseasealcohol-induced liver dysfunctionalcohol-mediated liver dysfunctionalcohol-mediated liver injuryalcohol-related liver diseasealcoholic beverage consumptionalcoholic drink intakealcoholic liver injuryanakinraantagonismantagonistanti-microbial effectbehavior interventionbehavior studybehavioral interventionbehavioral studybiological specimen repositorybiosample repositorybiospecimen bankbiospecimen repositorycare as usualcare outcomescatalystclinical centerclinical interventionclinical therapycohortcombination therapycombined modality treatmentcombined treatmentdata basedata depositorydata repositorydata set repositorydataset repositorydelta-Cortisonedrink heavilydrinkingdrug interventiondrug treatmentethanol abstinenceethanol consumptionethanol drinkingethanol induced hepatic injuryethanol induced liver disorderethanol induced liver injuryethanol ingestionethanol intakeethanol liver diseaseethanol misuseethanol product useethanol useethanol use disorderethanol-induced hepatic dysfunctionethanol-induced liver diseaseethanol-induced liver dysfunctionethanol-mediated liver dysfunctionethanol-mediated liver injuryexcessive alcohol consumptionexcessive alcohol ingestionexcessive alcohol intakeexcessive drinkingexcessive ethanol ingestionextreme drinkinghealth care outcomeshealth care personnelhealth care workerhealth providerhealth workforcehealthy volunteerheavy alcohol usehepatic body systemhepatic diseasehepatic organ systemhepatopathyimprovedinterleukin 1 receptor antagonist proteininterleukin-22liver disorderlongitudinal databasemedical personnelmeetingmeetingsmortalitymotivational enhancement therapymotivational interviewmulti-modal therapymulti-modal treatmentnew drug targetnew drug treatmentsnew druggable targetnew drugsnew pharmacological therapeuticnew pharmacotherapy targetnew therapeutic targetnew therapeuticsnew therapynew therapy targetnext generation therapeuticsnovelnovel drug targetnovel drug treatmentsnovel druggable targetnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel pharmacotherapy targetnovel therapeutic targetnovel therapeuticsnovel therapynovel therapy targetopen labelopen label studyoptimal therapiesoptimal treatmentspatient oriented outcomespatient populationpatient registrypharmaceutical interventionpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticsprimary end pointprimary endpointprogramsprospectiverandomisationrandomizationrandomized control trialrandomly assignedsocial stigmaspecimen bankspecimen repositorystandard of carestigmastudy designtranslation researchtranslational investigationtranslational studytransplanttreatment as usualtreatment providertreatment strategytrial designtrial regimentrial treatmentunhealthy alcohol useurine IL-1 inhibitorurine interleukin 1 inhibitorurine-derived IL1 inhibitorusual care
Description preview
Alcohol-associated liver disease (ALD) is a leading cause of liver-related mortality/morbidity, and there is no FDA-approved therapy for any stage of ALD. Advanced ALD conditions, including severe alcohol-associated hepatitis (sAH) have especially poor outcomes. Indeed, the 90-day mortality for sAH is ~30%. Return to drinking impacts quality of…
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