grant
Integrated multimodal phenotyping of zebrafish models of human cognitive disorders
Organization UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAHLocation SALT LAKE CITY, UNITED STATESPosted 20 Sept 2024Deadline 31 Aug 2029
NIHUS FederalResearch GrantFY2025AcousticsAddressAnimal ModelAnimal Models and Related StudiesAnimalsAssayBar CodesBasal Transcription FactorBasal transcription factor genesBehaviorBehavioralBehavioral AssayBioassayBiologicalBiological AssayBiologyBrachydanio rerioBrainBrain Nervous SystemBrain regionCRISPRCRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas systemCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCas nuclease technologyCell FunctionCell PhysiologyCell ProcessCellular FunctionCellular MorphologyCellular PhysiologyCellular ProcessCellular biologyCharacteristicsClustered Regularly Interspaced Short Palindromic RepeatsClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyCognition DisordersCognitiveCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalComputational toolkitDNADanio rerioDataData AnalysesData AnalysisData ScienceData SetDedicationsDeoxyribonucleic AcidDescriptorDevelopmentDevelopmental BiologyDimensionsDiseaseDisorderDisturbance in cognitionDrop-seqEmbryoEmbryonicEncephalonExpression SignatureFosteringGene Expression ProfileGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGenerationsGenesGeneticGenetic DiseasesGenetic TranscriptionGenotypeGoalsHumanImageImpaired cognitionIndividualInformaticsJointsKnock-outKnockoutLaboratoriesLarvaLeadLinkMachine LearningManualsMeasurementMeasuresMentorsMentorshipMethodologyMicrofluidicsModelingModern ManMolecularMolecular Modeling Nucleic Acid BiochemistryMolecular Modeling Protein/Amino Acid BiochemistryMolecular ModelsMorphologyMutateNerve CellsNerve UnitNeural CellNeurocyteNeurodevelopmental DisorderNeurological Development DisorderNeuronsPathway interactionsPb elementPhenotypePhysiologicPhysiologicalPostdocPostdoctoral FellowProtocolProtocols documentationQuantitative MicroscopyRNA ExpressionResearchResearch AssociateResearch MethodologyResearch MethodsResolutionSamplingStimulusStructureSubcellular ProcessSyndromeSystemTechniquesTechnologyTherapeutic InterventionTimeTrainingTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesUniversitiesUtahVisualWorkZebra DanioZebra FishZebrafishbarcodebehavior outcomebehavior phenotypebehavioral outcomebehavioral phenotypingbiologicbrain morphologycareer developmentcell biologycell morphologycell typecognitive diseasecognitive disordercognitive dysfunctioncognitive losscognitive syndromecohortcomputational toolboxcomputational toolscomputational toolsetcomputer based predictioncomputerized toolsdata interpretationdevelopmentaldisease modeldisorder modeldroplet sequencingexperimentexperimental researchexperimental studyexperimentsfull scale manufacturingfunctional genomicsgene expression patterngene expression signaturegene functiongenetic conditiongenetic disordergenome editinggenomic editingglobal gene expressionglobal transcription profileheavy metal Pbheavy metal leadhigh dimensionalityhuman modelimagingimprovedinsightintervention therapyknowledge integrationlarge scale manufacturinglarge scale productionmachine based learningmachine learning based prediction modelmachine learning based predictive modelmachine learning predictionmachine learning prediction modelmachine visionmass productionmembermodel of animalmodel of humanmolecular modelingmolecular phenotypemulti-modalitymultimodalitymutantneurodevelopmental diseaseneuronalnew approachesnew technologynew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovel approachesnovel strategiesnovel strategynovel technologiesnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachpathwayphenotypic datapost-docpost-doctoralpost-doctoral traineepredictive modelingresearch and methodsresearch associatesresolutionsresponsescRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingtherapeutic agent developmenttherapeutic developmenttooltranscription factortranscriptional profiletranscriptional signaturetranscriptomeµfluidic
Description preview
Neurodevelopmental disorders often have clear genetic components but linking genotype to phenotype remains
challenging. Recent advances in genome editing technology have enabled the rapid generation of animal models
for cognitive genetic disorders. However, the differing methodologies used across laboratories to phenotype
these models confounds…
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