grant
INROADS Project 2
Organization ICAHN SCHOOL OF MEDICINE AT MOUNT SINAILocation NEW YORK, UNITED STATESPosted 15 May 2026Deadline 30 Apr 2031
NIHUS FederalResearch GrantFY20260-11 years old21+ years oldAddressAdultAdult HumanAffectAllergic ReactionAllergic to foodAllergy to foodAllergy to peanutsAnaphylactic ReactionAnaphylactic ShockAnaphylaxisAngioedemaAngioneurotic EdemaBiologicalBiological MarkersCardiovascularCardiovascular Body SystemCardiovascular Organ SystemCardiovascular systemCell BodyCell FunctionCell PhysiologyCell ProcessCellsCellular FunctionCellular PhysiologyCellular ProcessChildChild YouthChildren (0-21)ClassificationClinicalClinical PathsClinical PathwaysDistressDrugsExpression SignatureFDA approvedFDA licensed drugsFDA-approved agentsFDA-approved drugFDA-approved medicationsFDA-approved pharmaceuticalsFDA-approved therapeutic agentFood AllergyFood HypersensitivityFood and Drug Administration approved drugFood and Drug Administration approved medicationsFood and Drug Administration approved pharmaceuticalsGene Expression ProfileGiant UrticariaGoalsGroundnut HypersensitivityHeart VascularHivesImmune mediated therapyImmunochemical ImmunologicImmunologicImmunologicalImmunologicallyImmunologically Directed TherapyImmunologicsImmunotherapyIndividualIngestionLifeMachine LearningMedicationModalityOralPatientsPeanut HypersensitivityPerformancePharmaceutical PreparationsPopulationProbabilistic ModelsProbability ModelsProteinsPublic HealthQuincke's EdemaRNA SeqRNA sequencingRNAseqReactionRiskRisk ReductionSpecificityStatistical ModelsSubcellular ProcessSystematicsT-CellsT-LymphocyteTestingTranscriptUnited StatesUrticariaadulthoodallergic reaction to peanutallergic response to peanutallergic to peanutsanti-IgEanti-IgEidbio-markersbiologicbiologic markerbiomarkercirculatory systemclinical implementationcohortcomparativedesensitizationdrug/agentexperiencefood challengegastrointestinalgene expression patterngene expression signatureglobal gene expressionglobal transcription profileimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based therapiesimmune-based treatmentsimmuno therapyimprovedingestkidsmachine based learningmachine learning based methodmachine learning methodmachine learning methodologiesomalizumaboral immunotherapypeanut allergicpeanut allergyperformance testsperipheral bloodreduce riskreduce risksreduce that riskreduce the riskreduce these risksreduces riskreduces the riskreducing riskreducing the riskrespiratoryrisk-reducingstatistical linear mixed modelsstatistical linear modelsthymus derived lymphocytetooltranscriptional profiletranscriptional signaturetranscriptometranscriptome sequencingtranscriptomic sequencingtranscriptomicsyoungster
Description preview
SUMMARY – Project 2: Signatures and Classifiers of Peanut Desensitization (SPADE)
Peanut allergy is a clinical and public health problem that affects 2.2% of children and 1.8% of adults in the
United States. While there remains no cure for peanut allergy, desensitization treatment reduces sensitivity to
peanut such that small exposures may not…
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