grant

Innovations in Functional B Cell Epitope Discovery for Food Allergy

Organization STANFORD UNIVERSITYLocation STANFORD, UNITED STATESPosted 30 Sept 2025Deadline 29 Sept 2026
NIHUS FederalResearch GrantFY2025AllergensAllergicAllergic to foodAllergyAllergy to foodAntibodiesAntigenic DeterminantsB blood cellsB cellB cell receptorB cellsB-Cell Antigen ReceptorB-Cell EpitopesB-CellsB-Lymphocyte EpitopesB-LymphocytesB-cellBinding DeterminantsBlood PlasmaBlood SampleBlood specimenBovine SpeciesCashewCashew nutCattleCell DegranulationClinicalClone CellsEpitopesExposure toFoodFood AllergyFood HypersensitivityGoalsHeterogeneityHumanIgEIgG1IgG4Immunoglobulin EMarrow Mast CellMilkModern ManPatientsPlasmaPlasma SerumProteinsReticuloendothelial System, Serum, PlasmaSerologyShrimpSpecificityTissue BasophilsTissue Samplebovidbovinechicken eggcowfood allergenfood challengeinnovateinnovationinnovativemast cellmastocyteoral immunotherapyresponse
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Full Description

The goal of the proposal is to obtain fundamental functional understanding of human B cell epitopes in food allergy and in response to oral immunotherapies for food allergy. The clinical and serological features of patients who have allergies to different foods suggest that there may be heterogeneity in allergen-specific B cell clones or antibody features for these allergens. This proposal will analyze the epitope targets of allergic patient B cell receptors and antibodies.

Grant Number: 75N93024C00075-P00001-9999-1
NIH Institute/Center: NIH

Principal Investigator: SCOTT BOYD

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