grant
Initiation of a cohort to define pathogenic Mechanisms, Precision diagnosis And Complications of Thrombotic Microangiopathies: The IMPACT Study
Organization JOHNS HOPKINS UNIVERSITYLocation BALTIMORE, UNITED STATESPosted 15 Sept 2025Deadline 30 Jun 2030
NIHUS FederalResearch GrantFY20250-11 years old21+ years oldADAMTSAccess to InformationAcuteAddressAdultAdult HumanApoplexyAssayAutoantibodiesAutoimmune ThrombocytopeniasAutoimmune Thrombocytopenic PurpuraBasic ResearchBasic ScienceBioassayBiologicalBiological AssayBlood PlasmaBlood VesselsBrain Vascular AccidentBrain Vascular DisordersCardiac DiseasesCardiac DisordersCardiac infarctionCardiovascularCardiovascular Body SystemCardiovascular DiseasesCardiovascular Organ SystemCardiovascular systemCell BodyCellsCerebral InfarctionCerebral StrokeCerebrovascular ApoplexyCerebrovascular DiseaseCerebrovascular DisordersCerebrovascular StrokeCessation of lifeChildChild YouthChildren (0-21)ChronicChronic Kidney FailureChronic Renal DiseaseChronic Renal FailureClinicalClinical DataClinical ResearchClinical StudyClinical TrialsClottingCoagulationCoagulation ProcessCognitiveCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalCollaborationsComplementComplement InactivatorsComplement InhibitorsComplement ProteinsDataDeathDevelopmentDiagnosisDisease OutcomeDisease remissionDisturbance in cognitionESKDESRDEnd stage renal failureEnd-Stage Kidney DiseaseEnd-Stage Renal DiseaseEsteroproteasesEvaluationEventFDA approvedFamilyFosteringFundingFutureFuture GenerationsGasser's SyndromeGeneticGoalsGuidelinesHealthHealth StatusHeart DiseasesHeart VascularHemolysisHemolytic AnemiaHemolytic-Uremic SyndromeHypertensionIQ DeficitIdiopathic Thrombocytopenic PurpuraImmuneImmune mediated therapyImmune thrombocytopeniaImmunesImmunologically Directed TherapyImmunosuppressionImmunosuppression EffectImmunosuppressive EffectImmunotherapyImpaired cognitionImpairmentIndividualInfrastructureInternationalIntervention TrialInterventional trialIntracranial Vascular DiseasesIntracranial Vascular DisordersInvestigatorsIschemiaKidneyKidney Urinary SystemLevel of HealthLifeMeasuresMediatingMedicalMedical SocietiesMental DepressionMorbidityMorbidity - disease rateMoschkowitz DiseaseMyocardial InfarctMyocardial InfarctionNeurocognitive DeficitOrphan DiseaseOutcomePathogenesisPathogenicityPatient EducationPatient InstructionPatient Outcomes AssessmentsPatient Reported MeasuresPatient Reported OutcomesPatient TrainingPatient advocacyPatientsPeptidasesPeptide HydrolasesPersonsPhenotypePlasmaPlasma ExchangePlasma SerumPregnancy OutcomeProspective cohortProtease GeneProteasesProteinasesProteolytic EnzymesPublicationsRare DiseasesRare DisorderRecombinantsRecoveryRecurrenceRecurrentRecurrent diseaseRegistriesRelapseRelapsed DiseaseRemissionReportingResearch PersonnelResearch ProposalsResearch TrainingResearchersReticuloendothelial System, Serum, PlasmaRiskRoleSamplingScientific PublicationScientific SocietiesScientistStrokeSurvivorsThrombocytopeniaThrombocytopenic PurpuraThrombopeniaThrombopenic PurpuraThrombosisThrombotic Thrombocytopenic PurpuraThrombotic Thrombopenic PurpuraTimeTrainingTranslational ResearchTranslational ScienceUnited StatesVascular Hypertensive DiseaseVascular Hypertensive DisorderWerlhof's Diseaseadulthoodautoimmune antibodyautoreactive antibodybiologicbrain attackbrain vascular diseasebrain vascular dysfunctioncardiac infarctcardiovascular disordercareercerebral infarctcerebral vascular accidentcerebral vascular diseasecerebral vascular dysfunctioncerebrovascular accidentcerebrovascular dysfunctionchronic kidney diseasecirculatory systemclinical practiceclinical remissionclinical research siteclinical siteclinical trainingclinical trial readinessco-morbidco-morbiditycognitive dysfunctioncognitive functioncognitive losscohortcomorbiditycomplementationconferenceconventioncoronary attackcoronary infarctcoronary infarctiondepositorydepressiondevelopmentalerythrolysisexperiencehealth levelheart attackheart disorderheart infarctheart infarctionhigh blood pressurehyperpiesiahyperpiesishypertensive diseasehypertensive disorderimmune suppressionimmune suppressive activityimmune suppressive functionimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune thrombocytopenic purpuraimmune-based therapiesimmune-based treatmentsimmuno therapyimmunosuppressive activityimmunosuppressive functionimmunosuppressive responseimprovedindustrial partnershipindustry partnerindustry partnershipinhibitorinjury to organsintelligence quotient deficitintracranial vascular dysfunctionkidslife spanlifespanlong-term sequelaemortalitymultidisciplinaryneurocognitive declineneurocognitive impairmentnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapeuticsnew therapynew therapy approachesnew treatment approachnew treatment strategynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapeuticsnovel therapynovel therapy approachorgan injuryorphan disorderoutreach to informationpatient advocacy groupprospectiverenalrepositoryself reactive antibodysocial rolestrokedstrokessummitsymposiasymposiumthromboembolic complicationsthrombosis complicationsthromboticthrombotic complicationsthrombotic diseasethrombotic disordertranslation researchtranslational investigationtreatment researchtreatment strategyvascularweb sitewebsiteyoungster
Description preview
PROJECT SUMMARY - OVERALL
The overall goal of this proposal is to create a Rare Disease Clinical Research Consortium (RDCRC) to
facilitate collaborative clinical and translational research, patient advocacy and education, and training
clinicians and researchers focused on thrombotic microangiopathies (TMAs). TMAs are a group of rare
disorders…
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