grant
Inhibition of Fibrinogen Reduces Brain Injury and Hydrocephalus in Premature Neonates with Intraventricular Hemorrhage
Organization ALBERT EINSTEIN COLLEGE OF MEDICINELocation BRONX, UNITED STATESPosted 1 Apr 2026Deadline 31 Mar 2028
NIHUS FederalResearch GrantFY20260-4 weeks old1,2,3-Propanetriol1,2,3-TrihydroxypropaneAD dementiaAccelerationAcquired brain injuryAdverse effectsAlteplaseAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimers DementiaAnimal ModelAnimal Models and Related StudiesAnimalsAntibodiesAntigenic DeterminantsAqueduct of SylviusAreaBindingBinding DeterminantsBleedingBloodBlood - brain barrier anatomyBlood ClottingBlood Coagulation FactorBlood Coagulation Factor IBlood Coagulation Factor OneBlood Factor OneBlood Reticuloendothelial SystemBlood coagulationBlood-Brain BarrierBone-Derived Transforming Growth FactorBrainBrain InjuriesBrain Nervous SystemBrain TraumaBrain VentricleBrain regionCD11bCD18CR3CR3 ReceptorCR3ACell IsolationCell SegregationCell SeparationCell Separation TechnologyCerebral PalsyCerebral VentriclesCerebral aqueductCicatrixCirculationClinical Treatment MoabClottingCoagulationCoagulation Factor ICoagulation Factor OneCoagulation FactorsCoagulation ProcessCognitive deficitsCommunicating HydrocephalusComplement 3 ReceptorComplicationDepositDepositionDevelopmentDiseaseDisorderDisseminated SclerosisDomestic RabbitDoseEncapsulatedEncephalonEpitopesExtravasationFactor IFactor OneFibrinFibrinogenFourth VentricleFourth Ventricle of the BrainFourth ventricle structureGestationGlandulae PacchioniGlycerinGlycerolHemato-Encephalic BarrierHemorrhageHortega cellHydrocephalusHydrocephalyHypoxic-Ischemic Brain InjuryITGAMITGAM geneITGB2ITGB2 geneImmune mediated therapyImmunologically Directed TherapyImmunotherapyInfantInflammationIntegrin alpha-M beta-2Integrin alphaMbeta2IntegrinsIntegrins Extracellular MatrixIntraventricularLCAMBLeakageLipidsLymphaticMAC1AMF17MO1AMac 1Mac-1 Adhesive ReceptorMac-1 AntigenMac-1 ReceptorMacrophageMacrophage-1 AntigenMediatingMeningeal circuitMeningeal lymphatic networkMeningeal lymphatic pathwayMeningeal lymphatic systemMeningeal lymphaticsMicrogliaMilk Growth FactorMo1 Antigen ReceptorMo1 Glycoprotein ReceptorModelingMolecular InteractionMonoclonal AntibodiesMorphologyMultiple SclerosisMφNADH oxidaseNADPH OxidaseNerve CellsNerve UnitNervous System DiseasesNervous System DisorderNeural CellNeurocyteNeurologicNeurologic DisordersNeurologic DysfunctionsNeurologicalNeurological DisordersNeuronsNeuroprotectantsNeuroprotective AgentsNeuroprotective DrugsNewborn InfantNewbornsObstructive HydrocephalusOligodendrocytesOligodendrocytusOligodendrogliaOligodendroglia CellOryctolagus cuniculusOxidasesOxidative StressPathologicPathologyPathway interactionsPeptide antibodiesPeptidesPlatelet Transforming Growth FactorPlatelet aggregationPlayPregnancyPremature InfantPrimary Senile Degenerative DementiaProgenitor CellsPublishingRNA SeqRNA sequencingRNAseqRabbitsRabbits MammalsReceptor ProteinRecombinant Tissue Plasminogen ActivatorRoleRouteScarsSignal PathwaySiteSpillageSubarachnoid SpaceSurvivorsT-Plasminogen ActivatorTGF BTGF-betaTGF-βTGFbetaTGFβTestingTherapeuticThrombusTimeTissue Activator D-44Tissue Plasminogen ActivatorTissue-Type Plasminogen ActivatorTransforming Growth Factor betaTransforming Growth Factor-Beta Family GeneTraumatic Brain InjuryVentricularVillusarachnoid villiastrogliosisblood lossbloodbrain barrierbrain damagebrain parenchymabrain-injuredcell sortingclotting factorcognitive defectscompare to controlcomparison controldevelopmentaldisabilityfibrinogen-gamma chainfibrinopeptides gammagitter cellglial activationglial cell activationglobal gene expressionglobal transcription profilehydrocephalicimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based therapiesimmune-based treatmentsimmuno therapyinfants born prematureinfants born prematurelyinsular sclerosisintraventricular hemorrhagemAbsmesogliamicroglial cellmicrogliocytemodel of animalmonoclonal Absmotor behaviormyelinationnano vesiclenanovesicleneonatal careneurobehaviorneurological diseaseneurological dysfunctionneuronalnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynewborn childnewborn childrennext generation therapeuticsnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyoligodendrocyte precursoroligodendrocyte precursor celloligodendrocyte progenitoroligodendrocyte stem cellpathwayperineuralperivascular glial cellprematurepremature babypremature infant humanpremature neonatespremature newbornprematuritypreterm babypreterm infantpreterm infant humanpreterm neonatepreterm newbornpreventpreventingprimary degenerative dementiareceptorrepairrepairedresponsesenile dementia of the Alzheimer typesite targeted deliverysocial rolestem cellst-PAtargeted deliverytranscriptometranscriptome sequencingtranscriptomic sequencingtranscriptomicstraumatic brain damagewhite matter injuryαMβ2
Description preview
ABSTRACT
The occurrence of intraventricular hemorrhage (IVH) leads to posthemorrhagic white matter injury (WMI) and
hydrocephalus. No optimal therapeutic strategy exists to minimize these complications of IVH. The occurrence
of IVH results in the formation of fibrin clots in the ventricle and extravasation of blood in the periventricular brain…
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