grant
Influence of the Menopausal Transition and Lifetime Ovarian Exposure on Neural Metabolism, Connectivity and Pathology
Organization MASSACHUSETTS GENERAL HOSPITALLocation BOSTON, UNITED STATESPosted 15 Mar 2024Deadline 28 Feb 2029
NIHUS FederalResearch GrantFY2026AD biological markerAD biomarkerAD dementiaAD pathologyAD pathwayAD related biomarkerAD riskAD risk factorAD-associated pathwaysAD-related pathwaysAD-specific pathwaysAPOEAbscissionAccelerationAccountingAffectAgeAllelesAllelomorphsAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer disease mechanismAlzheimer pathwayAlzheimer risk factorAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimer's Disease PathwayAlzheimer's biomarkerAlzheimer's disease biological markerAlzheimer's disease biomarkerAlzheimer's disease pathologyAlzheimer's disease related biomarkerAlzheimer's disease riskAlzheimer's mechanismAlzheimer's pathologyAlzheimer's related biomarkerAlzheimer's related pathwaysAlzheimers DementiaAlzheimer’s biological markerAmyloidAmyloid SubstanceAmyloid depositionApo-EApoE proteinApolipoprotein EAquadiolBiological MarkersBrainBrain Nervous SystemBrain regionCellular ExpansionCellular GrowthCerebrumCharacteristicsCognitionCognitiveDevelopmentDifferences between sexesDiffers between sexesDimenformonDiogynDiogynetsEncephalonEstraceEstradiolEstradiol-17 betaEstradiol-17betaEstraldineEstrogensExcisionExposure toExtirpationFoundationsFunctional MRIFunctional Magnetic Resonance ImagingGenesGenetic PredispositionGenetic Predisposition to DiseaseGenetic RiskGenetic SusceptibilityGenetic propensityGenotypeImpairmentIndividualInherited PredispositionInherited SusceptibilityIntermediary MetabolismInvestigatorsLaboratoriesLeadLightMeasuresMediatingMemoryMenarcheMenopausal StatusMenopauseMetabolicMetabolic ProcessesMetabolismMidlife womenModelingNerve DegenerationNeuron DegenerationNeuronal InjuryOvarianOvarian hormoneOvocyclinOvocylinPETPET ScanPET imagingPETSCANPETTParticipantPathologyPatternPb elementPerformancePerimenopausalPerimenopausePersonsPhotoradiationPlayPositron Emission Tomography Medical ImagingPositron Emission Tomography ScanPositron-Emission TomographyPost-MenopausePost-menopausal PeriodPostmenopausal PeriodPostmenopausePre-MenopausePre-menopausal PeriodPremature MenopausePremenopausalPremenopausal PeriodPremenopausePrimary Senile Degenerative DementiaProcessProgynonPubertyPublic HealthRad.-PETRemovalResearchResearch PersonnelResearchersRestRiskRisk ReductionRoleSample SizeSamplingSex DifferencesSexual differencesSurgical RemovalSymptomsSynaptic plasticityTestingTherapeutic EstradiolTherapeutic EstrogenWomanaccumulated exposureaccumulated long-term exposureafter menopauseagesaggregate exposurealzheimer riskamyloid pathologybio-markersbiologic markerbiomarkerbiomarker in ADbiomarker in Alzheimer'sbiomarker in Alzheimer's diseasebrain metabolismcell growthcerebralcognitive functioncumulative exposurecumulative life exposurecumulative long-term exposuredevelop therapydevelopmentalearly menopauseexperiencefMRIfemale at midlifefollowing menopausegenetic vulnerabilitygenetically predisposedglucose metabolismheavy metal Pbheavy metal leadintervention developmentlater in lifelater lifelife-course exposurelifelong exposurelifespan exposurelifetime exposuremechanisms in ADmechanisms in Alzheimer's diseasemenmenopause transitionmid lifemid-lifemid-life femalemiddle agemiddle agedmiddle-aged femalemiddle-aged womenmidlifeneuralneural degenerationneural imagingneural modelneuro-imagingneurodegenerationneurodegenerativeneuroimagingneurological degenerationneurological imagingneuron developmentneuron injuryneuronal degenerationneuronal developmentpast menopausepathways associated with ADpathways associated with Alzheimer'spathways contribute to Alzheimer'spathways involved in Alzheimer diseasepathways that contribute to ADpathways that drive ADpathways underlying Alzheimer'speri-menopausalperi-menopausepositron emission tomographic (PET) imagingpositron emission tomographic imagingpositron emitting tomographypost-menopausalpostmenopausalpostmenopausal statuspre-menopausalpremature age of menopausepremenopausal statusprimary degenerative dementiaprotective effectreduce riskreduce risksreduce that riskreduce the riskreduce these risksreduces riskreduces the riskreducing riskreducing the riskresectionresilienceresilientrisk factor for developing Alzheimer'srisk factor in Alzheimer'srisk of developing Alzheimer'srisk-reducingsenile dementia of the Alzheimer typesex based differencessex-dependent differencessex-related differencessex-specific differencessocial rolesynapse functionsynaptic functiontherapy developmenttotality of exposurestransition to menopausetransitional menopausetreatment developmentwomen at midlifewomen in midlife
Description preview
Women are significantly more likely to develop Alzheimer’s disease than men, making up 2/3 of all AD cases.
Growing evidence suggests that this difference is related to the decline in ovarian hormone levels experienced
by women at midlife through menopause. Women who experience menopause later in life, and thus have a
longer lifespan exposure to…
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