grant
Influence of hypoxia on the antiviral functions of human intestinal epithelial cells
Organization UNIVERSITY OF FLORIDALocation GAINESVILLE, UNITED STATESPosted 4 Apr 2025Deadline 31 Mar 2030
NIHUS FederalResearch GrantFY2026AddressAlimentary CanalAnti-viral ResponseAutomobile DrivingBacteriaBasal Transcription FactorBasal transcription factor genesBiochemicalBiomedical EngineeringCasein Kinase TSCasein Kinase-2Cell BodyCell Communication and SignalingCell DifferentiationCell Differentiation processCell SignalingCellsCessation of lifeCharacteristicsChildhoodClinicalCommunicable DiseasesDataDeathDephosphorylationDevelopmentDiarrheaDigestive TractEnteralEntericEnterocytesEnvironmentEpithelial CellsFLJ11330FaceFlareGI TractGastroenteritisGastrointestinal TractGastrointestinal tract structureGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGoalsHumanHypoxiaHypoxicIFNIFN-regulatory factor 3IRF-3 proteinIRF3IRF3 geneImmuneImmune responseImmunesImpairmentIndividualInfectionInfectious DiseasesInfectious DisorderInflammationInflammatory Bowel DiseasesInflammatory Bowel DisorderInnate Immune ResponseInterferon Regulatory Factor 3InterferonsIntestinalIntestinesIntracellular Communication and SignalingKnowledgeLifeLife CycleLife Cycle StagesLiteratureMaintenanceMediatingModelingModern ManMolecularNF-Kb-Activating Kinase GeneNorovirusNorwalk-like VirusesO elementO2 elementOrganoidsOutcomeOxygenOxygen DeficiencyPathogenicityPathologyPatientsPhosphatasesPhosphohydrolasesPhosphomonoesterasesPhosphoprotein PhosphatasePhosphoprotein Phosphatase-2CPhosphoprotein PhosphohydrolasePhosphoric Monoester HydrolasesPhysiologicPhysiologicalPositionPositioning AttributePredispositionPreparationProductionProgenitor CellsProtein DephosphorylationProtein Kinase CK2Protein Kinase CKIIProtein Phosphatase CProtein Phosphatase GeneProtein Phosphatase-1Protein Phosphatase-2AProtein phosphataseProteinsReceptor ProteinResearch ProposalsRotavirusSignal TransductionSignal Transduction SystemsSignalingStructureSusceptibilityT2KTBK1TBK1 geneTechnologyTranscription Factor Proto-OncogeneTranscription factor genesTranslatingVillusViralViral ActivityViral DiseasesViral FunctionViral PhysiologyVirionVirusVirus DiseasesVirus ParticleVirus ReplicationWorkalimentary tractbio-engineeredbio-engineersbioengineeringbiological engineeringbiological signal transductionbowelcasein kinase IIcell typecellular differentiationcellular targetingchip modelchip systemcombatcommensal floracommensal microbescommensal microbiotacommensal microfloradevelopmentaldigestive canaldrivingenteral infectionenteral pathogenenteric infectionenteric pathogenenteric pathogen infectionenteric viral infectionenteric virus infectionenteropathogenenteropathogen infectionenteropathogenic infectionexperienceexperimentexperimental researchexperimental studyexperimentsfacesfacialgenetic approachgenetic strategyglobal healthgut homeostasishost responsehuman pathogenimmune system responseimmunoresponseimprovedinfected with enteropathogeninflammatory disease of the intestineinflammatory disorder of the intestineintestinal autoinflammationintestinal epitheliumintestinal infectionintestinal pathogenintestine infectionintestine pathogenlife coursemortalitynew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnormoxianovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targeton a chipon chiporgan chiporgan on a chiporgan on chippathogenpediatricpharmacologicpreparationspreservationreceptorresponsespatial integrationstem cellstranscription factorviral infectionviral multiplicationviral replicationvirus infectionvirus multiplicationvirus-induced disease
Description preview
Project Summary
Enteric viruses infect or initiate their lifecycle through the gastro-intestinal tract. Pathogenic enteric viruses
(e.g. rotavirus, norovirus) are of major clinical importance as they cause a great fraction of pediatric diarrheal
cases globally and can lead to life threatening infection in immune compromised patients. The…
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