grant
Influence of hypoxia on the antiviral functions of human intestinal epithelial cells
Organization UNIVERSITY OF FLORIDALocation GAINESVILLE, UNITED STATESPosted 4 Apr 2025Deadline 31 Mar 2030
NIHUS FederalResearch GrantFY2025AddressAlimentary CanalAllyAutomobile DrivingBacteriaBiochemicalBiomedical EngineeringCasein Kinase TSCasein Kinase-2Cell BodyCell Communication and SignalingCell DifferentiationCell Differentiation processCell SignalingCellsCessation of lifeChildhoodClinicalDataDeathDephosphorylationDevelopmentDiarrheaDigestive TractDiseaseDisorderEnteralEntericEnterocytesEnvironmentEpithelial CellsEpitheliumFLJ11330FaceFlareGI TractGastrointestinal TractGastrointestinal tract structureGenesGoalsHumanHypoxiaHypoxicIFNIFN-regulatory factor 3IRF-3 proteinIRF3IRF3 geneImmuneImmune responseImmunesImpairmentIndividualInfectionInflammationInflammatory Bowel DiseasesInflammatory Bowel DisorderInnate Immune ResponseInterferon Regulatory Factor 3InterferonsIntestinalIntestinesIntracellular Communication and SignalingKnowledgeLifeLife CycleLife Cycle StagesLiteratureMaintenanceMediatingModelingModern ManMolecularNF-Kb-Activating Kinase GeneNorovirusNorwalk-like VirusesO elementO2 elementOrganoidsOutcomeOxygenOxygen DeficiencyPartner in relationshipPathogenicityPathologyPatientsPhosphatasesPhosphohydrolasesPhosphomonoesterasesPhosphoprotein PhosphatasePhosphoprotein Phosphatase-2CPhosphoprotein PhosphohydrolasePhosphoric Monoester HydrolasesPhysiologicPhysiologicalPredispositionPreparationProductionProgenitor CellsProtein DephosphorylationProtein Kinase CK2Protein Kinase CKIIProtein Phosphatase CProtein Phosphatase GeneProtein Phosphatase-1Protein Phosphatase-2AProtein phosphataseProteinsReceptor ProteinResearch ProposalsRotavirusSignal TransductionSignal Transduction SystemsSignalingStructureSusceptibilityT2KTBK1TBK1 geneTechnologyTranslatingVillusViralViral ActivityViral DiseasesViral FunctionViral PhysiologyVirusVirus DiseasesVirus ReplicationWorkalimentary tractbio-engineeredbio-engineersbioengineeringbiological engineeringbiological signal transductionbowelcasein kinase IIcell typecellular differentiationcellular targetingchip modelchip systemcombatcommensal floracommensal microbescommensal microbiotacommensal microfloradevelopmentaldigestive canaldrivingenteral infectionenteral pathogenenteric infectionenteric pathogenenteric pathogen infectionenteric viral infectionenteric virus infectionenteropathogenenteropathogen infectionenteropathogenic infectionexperienceexperimentexperimental researchexperimental studyexperimentsfacesfacialglobal healthgut homeostasishost responsehuman pathogenimmune system responseimmunoresponseimprovedinfected with enteropathogeninflammatory disease of the intestineinflammatory disorder of the intestineintestinal autoinflammationintestinal epitheliumintestinal infectionintestinal pathogenintestine infectionintestine pathogenlife coursematemortalitynew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnormoxianovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targeton a chipon chiporgan chiporgan on a chiporgan on chippathogenpediatricpharmacologicpreparationspreservationreceptorresponsespatial integrationstem cellsviral infectionviral multiplicationviral replicationvirus infectionvirus multiplicationvirus-induced disease
Description preview
Project Summary
Enteric viruses infect or initiate their lifecycle through the gastro-intestinal tract. Pathogenic enteric viruses
(e.g. rotavirus, norovirus) are of major clinical importance as they cause a great fraction of pediatric diarrheal
cases globally and can lead to life threatening infection in immune compromised patients. The…
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