grant
Inflammation Phenotypes in Pediatric Sepsis Induced Multiple Organ Failure Renewal
Organization UNIVERSITY OF PITTSBURGH AT PITTSBURGHLocation PITTSBURGH, UNITED STATESPosted 1 Mar 2014Deadline 30 Jun 2028
NIHUS FederalResearch GrantFY20250-11 years old21+ years old7S Gamma GlobulinAddressAdultAdult HumanAmericanAnti-InflammatoriesAnti-Inflammatory AgentsAnti-inflammatoryAssayAtrophic ArthritisAutoimmune StatusAutoimmunityBig DataBigDataBioassayBioinformaticsBiological AssayBlood PlasmaBurkitt HerpesvirusBurkitt Lymphoma VirusCCL2CCL2 geneCancersCessation of lifeCharacteristicsChemokine, CC Motif, Ligand 2ChildChild YouthChildren (0-21)ClinicalClinical DataClinical TrialsClinical Trials DesignClottingCoagulationCoagulation ProcessComputersCytochrome P-450Cytochrome P-450 Enzyme SystemCytochrome P450Cytochrome P450 Family GeneD-GlucoseDNA Molecular BiologyData SetDeathDextroseDimethylbiguanidineDimethylguanylguanidineDiseaseDisorderDisseminated SclerosisEB virusEBVEBV InfectionsEBV latencyEnergy ExpenditureEnergy MetabolismEnrollmentEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEpstein Barr VirusEpstein-Barr Virus InfectionsEpstein-Barr Virus latencyEpstein-Barr viral infectionsFundingGene variantGenesGlucoseHHV-4HHV4Hereditary Metabolic DisorderHourHuman GeneticsHuman Herpesvirus 4IgGImmuneImmune mediated therapyImmune responseImmunesImmunityImmunoglobulin GImmunologically Directed TherapyImmunomodulationImmunotherapyInborn Errors of MetabolismIndividualInfectionInfectious Mononucleosis VirusInflammationInflammatoryIntermediary MetabolismInvestigatorsLaboratoriesLatent virus infection phaseLeadLifeLinkLong COVIDLong COVID-19Long coronavirus diseaseLong coronavirus disease 2019Long-term infectionLupus Erythematosus DisseminatusLymphocytopeniaLymphopeniaMCAFMCP-1MCP1MOF syndromeMachine LearningMacrophage ActivationMacrophage activation syndromeMalignant NeoplasmsMalignant TumorMeasuresMediatingMetabolicMetabolic PathwayMetabolic ProcessesMetabolismMetforminMethylationMolecularMolecular BiologyMonocyte Chemoattractant Protein-1Monocyte Chemotactic Protein-1Monocyte Chemotactic and Activating FactorMonocyte Chemotactic and Activating ProteinMonocyte Chemotactive and Activating FactorMonocyte Secretory Protein JEMultiple Organ Dysfunction SyndromeMultiple Organ FailureMultiple SclerosisN,N-dimethyl-imidodicarbonimidic diamideNGS MethodNGS systemNamesOrganOrgan failureOutcomeOxidative PhosphorylationOxidative Phosphorylation PathwayP450PathogenicityPatientsPb elementPhenotypePlacebo ControlPlasmaPlasma SerumPrecision medicine trialPrimary ImmunodeficiencyProliferatingResearchResearch PersonnelResearchersReticuloendothelial System, Serum, PlasmaRheumatoid ArthritisRoleSCYA2SLESamplingSepsisSmall Inducible Cytokine A2SubgroupSystemic Lupus ErythematosusSystemic Lupus ErythematousSystemic Lupus ErythmatosusTechnologyTestingTherapy trialThrombocytopeniaThrombopeniaUnited StatesVariantVariationViral GeneticsVirusadulthoodaerobic glycolysisallelic variantbiobankbiorepositorychildren with sepsischronic COVIDchronic COVID-19chronic infectionchronic novel coronavirus disease 2019congenital immune deficiencycongenital immunodeficiencycustomized therapycustomized treatmentcytokinedeath due to sepsisdeath related to sepsisdesigndesigningdisseminated lupus erythematosusdrug repositioningdrug repurposingenrollepigeneticallyexomegenetic immune defectgenetic immune deficiencygenetic immunodeficiencygenetic variantgenomic variantheavy metal Pbheavy metal leadhigh riskhost responseimmune modulationimmune regulationimmune system responseimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based therapiesimmune-based treatmentsimmuno therapyimmunologic reactivity controlimmunomodulatoryimmunoregulationimmunoregulatoryimmunoresponseimprovedinborn errors in immunityinborn errors of immunityinborn immunodeficiencyinborn metabolism disorderindividual patientindividualized medicineindividualized patient treatmentindividualized therapeutic strategyindividualized therapyindividualized treatmentindividuals with sepsisinherited immune defectinherited immune deficiencyinherited immunodeficiencyinsular sclerosiskidslatent viral infectionlatent virus infectionlong haul COVIDlong haul COVID-19long haul coronavirus diseaselong haul coronavirus disease 2019long-hauler COVIDlong-hauler COVID-19long-hauler coronavirus disease 2019long-hauler syndromelong-term COVIDlong-term COVID-19long-term coronavirus diseaselong-term coronavirus disease 2019machine based learningmalignancymetabolism measurementmetabolomicsmetabonomicsmortalitymortality associated with sepsismortality in sepsismultiorgan failuremultiple organ system failurenamenamednamingneoplasm/cancernew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext gen sequencingnext generation sequencingnext generation therapeuticsnextgen sequencingnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapypathogenpatient specific therapiespatient specific treatmentpatients with sepsispediatric sepsispediatric septicpeople with sepsispersistent COVID-19persistent infectionpersonalization of treatmentpersonalized medicinepersonalized therapypersonalized treatmentplacebo controlledpost COVID syndromepost COVID-19 syndromepost acute COVID syndromepost acute COVID-19post acute COVID-19 syndromepost acute SARS-CoV-2post acute coronavirus disease 2019post acute coronavirus disease 2019 syndromepost acute coronavirus disease syndromepost acute severe acute respiratory syndrome coronavirus 2post coronavirus disease 2019 syndromepost coronavirus disease syndromepost-acute phases of COVID-19precision medicineprecision-based medicineprimary immune defectprimary immune deficiencyprolonged COVID-19 symptomsrepurposing agentrepurposing medicationresponserheumatic arthritissepsis associated deathsepsis associated mortalitysepsis caused deathssepsis deathsepsis groupssepsis in childrensepsis induced deathsepsis induced mortalitysepsis lethalitysepsis mortalitysepsis patientssepsis populationsepsis related deathssepsis related mortalitysepsis subjectsseptic childrenseptic deathseptic groupseptic individualsseptic mortalityseptic patientsseptic peopleseptic populationseptic subjectsocial rolesubjects with sepsissystemic lupus erythematosistailored medical treatmenttailored therapytailored treatmenttargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmentthromboticunique treatmentvirus geneticsyoungster
Description preview
Project Abstract
Every year over 1 million American adults and children develop overwhelming infection leading to a rotting of
their body we call ‘sepsis’, and death in up to 1 of 4 afflicted. We and others have asked the question “why do
patients continue to die of organ shutdown?” In the previous funding period we used clinical information and…
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