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In-Vivo Monitoring of Therapeutic Drug Transport Across Biological Barriers
Organization JOHNS HOPKINS UNIVERSITYLocation BALTIMORE, UNITED STATESPosted 1 Sept 2021Deadline 2 Sept 2025 ⚠️
NIHUS FederalResearch GrantFY2025AcidityAcquired brain injuryAffectAminobenzyl PenicillinAminobenzylpenicillinAminoglycosidesAmmon HornAmoxicillinAmoxicillineAmoxilAmoxycillinAmpicillinAntibiotic AgentsAntibiotic DrugsAntibiotic PremedicationAntibiotic ProphylaxisAntibioticsBacteriaBehaviorBenzylpenicillinBiologicalBiopsyBloodBlood Reticuloendothelial SystemBlood capillariesBody TissuesBrainBrain InjuriesBrain Nervous SystemBrain regionCell LineCellLineCerebrospinal FluidCharacteristicsChemical StructureChemicalsChemoreceptorsClinicalCommon Rat StrainsComplexCornu AmmonisDangerousnessDataDetectionDevelopmentDoseDrug KineticsDrug TherapyDrug TransportDrugsEncephalonEndotheliumEnvironmentExposure toExtracellular SpaceFamilyFutureGaramicinGaramycinGenopticGenoptic S.O.P.GentamicinsGlycopeptide AntibioticsGlycopeptidesGoalsHippocampusHydroxyampicillinImplantIn VitroIn vivo analysisIndustryInfectionIntercellular SpaceInvestigatorsIrrigationJugular VeinsKanamycinKineticsKnowledgeLibrariesLiverMapsMeasurementMeasuresMedicalMedicationMembraneMethodologyMiscellaneous AntibioticModelingMolecularMolecular TransportMonitorNatureOperative ProceduresOperative Surgical ProceduresOrganPenetrating Brain InjuryPenetrationPenicillin GPerfusionPermeabilityPharmaceutical PreparationsPharmacokineticsPharmacological TreatmentPharmacotherapyPolymoxPorosityPreparationProphylactic treatmentProphylaxisProstateProstate GlandProstaticProstatic GlandRatRats MammalsRattusRegimenResearchResearch PersonnelResearch ResourcesResearchersResistance developmentResistant developmentResourcesSamplingStrains Cell LinesStructureStructure of jugular veinSurgicalSurgical InterventionsSurgical ProcedureTestingThalamic structureThalamusTherapeuticTherapeutic AgentsTimeTissuesTobramycinTobrexTransport ProcessTravelTrimoxU-GencinUtimoxVancomycinWorkWymoxaptamerbasebasesbeta lactam antibioticbeta-Lactamsbiologicblood cerebrospinal fluid barrierbrain damagebrain-injuredcapillarycarrier mediated transportcerebral spinal fluidchemical propertycomputer based predictioncontinuous monitoringcostcultured cell linedeveloping resistancedevelopmentaldrug developmentdrug interventiondrug treatmentdrug/agenthepatic body systemhepatic organ systemhippocampalimprovedin vivoin vivo evaluationin vivo monitoringin vivo testingirrigation therapymembrane structurenew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapypassive transportpersonalized drugspharmaceutical interventionpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticsprecision drugspredictive modelingpreparationspreventpreventingprogramsreal time monitoringrealtime monitoringresponsesensing technologysensorsensor technologysensor-based technologyside effectspatial and temporalspatial temporalspatiotemporalspinal fluidstandard of caresurgerytemporal measurementtemporal resolutionthalamictherapeutically effectivetime measurementtissue woundtumoruptakewoundwoundingwoundsβ lactam antibioticβ-Lactams
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Description preview
Project Summary
The ability of therapeutic drugs to access specific organs strongly depends on the nature of the blood-tissue
barrier at said organs. The prostate and brain, for example, have tight barriers with no intercellular gaps, and
most drugs cannot permeate them at sufficiently high levels to be therapeutically effective. Thus,…
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