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In Utero Exposure to Medications for Cardiometabolic Conditions and Risk of Congenital Malformations
Organization HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTHLocation BOSTON, UNITED STATESPosted 15 Jul 2025Deadline 18 Sept 2025 ⚠️
NIHUS FederalResearch GrantFY20250-11 years old1st trimesterACE InhibitorsAddressAdult-Onset Diabetes MellitusAdverse effectsAgonistAngiotensin I-Converting Enzyme InhibitorsAngiotensin-Converting Enzyme AntagonistsAngiotensin-Converting Enzyme InhibitorsAnimalsAnti-Hypertensive AgentsAnti-Hypertensive DrugsAnti-HypertensivesAnti-diabetic AgentsAnti-diabetic DrugsBMIBMI percentileBMI z-scoreBP reductionBirth DefectsBloodBlood PressureBlood Reticuloendothelial SystemBody Weight decreasedBody mass indexChildChild YouthChildren (0-21)CholesterolChronicClinicalClinical TrialsCohort StudiesCommon Rat StrainsCommunicationConcurrent StudiesCongenital AbnormalityCongenital Anatomical AbnormalityCongenital DefectsCongenital DeformityCongenital MalformationDataData BasesData SetData SourcesDatabasesDevelopmentDomestic RabbitDrug PrescribingDrug PrescriptionsDrugsEarly Placental PhaseEffectivenessElectronic Health RecordEmbryo DevelopmentEmbryogenesisEmbryonic DevelopmentEquilibriumExclusionExposure toFamiliarityFecundabilityFecundityFertilityFetusFirst Pregnancy TrimesterFirst TrimesterFutureGLP-1GLP-1 receptorGLP-I receptorGestationGlp-1Glycohemoglobin AGlycosylated hemoglobin AGoalsGuidelinesHb A1Hb A1a+bHb A1cHbA1HbA1cHealthHemoglobin A(1)High PrevalenceHumanHumulin RHypercholesteremiaHypertensionHypotensive AgentHypotensive DrugsIndividualInsulinInvestigatorsKetosis-Resistant Diabetes MellitusKininase II AntagonistsKininase II InhibitorsKnowledgeLeadershipLinkLive BirthMachine LearningMaternal AgeMaternal HealthMaturity-Onset Diabetes MellitusMeasurementMedicationMedicineMentorsMentorshipMethodsModern ManNIDDMNon-Insulin Dependent DiabetesNon-Insulin-Dependent Diabetes MellitusNoninsulin Dependent DiabetesNoninsulin Dependent Diabetes MellitusNovolin RObesityOralOryctolagus cuniculusOutcomePerinatalPerinatal CarePerinatal EpidemiologyPeripartumPharmaceutical EpidemiologyPharmaceutical PreparationsPharmacoepidemiologyPhasePositionPositioning AttributePregnancyPregnant WomenPrevalencePublic Health SchoolsQuetelet indexRabbitsRabbits MammalsRatRats MammalsRattusRegular InsulinRegulationRelative RisksResearchResearch DesignResearch PersonnelResearchersResidualResidual stateRiskRisk FactorsSafetyScoring MethodSlow-Onset Diabetes MellitusStable Diabetes MellitusStudy TypeT2 DMT2DT2DMTeratogenicTeratogenic effectsTeratogenicityTeratogensTrainingType 2 Diabetes MellitusType 2 diabetesType II Diabetes MellitusType II diabetesUncertain RiskUncertaintyUnited StatesUnplanned pregnancyVascular Hypertensive DiseaseVascular Hypertensive DisorderVisceralWeightWeight LossWeight ReductionWomanadiposityadult onset diabetesadverse consequenceadverse maternal outcomesadverse outcomeage at pregnancyagedanti-diabeticanti-hypertensionbalancebalance functionblood pressure reductionbody weight losscardiometaboliccardiometabolismcareerchildbearing ageclinical careclinical practiceco-morbidco-morbiditycohortcomorbiditycorpulencedata basedevelopmentaldoubtdrug epidemiologydrug/agentearly in pregnancyearly pregnanciesearly pregnancyearly stage of pregnancyelectronic health care recordelectronic health medical recordelectronic health plan recordelectronic health registryelectronic medical health recordexpectant motherexpectant womenexpecting motherexpecting womenexposed in uterofertile agefetalfetal exposureglucagon-like peptide 1glucagon-like peptide-1 receptorhemoglobin A1chigh blood cholesterolhigh blood pressurehigh dimensionalityhuman datahypercholesterolemiahyperpiesiahyperpiesishypertensive diseasehypertensive disorderimprovedin utero exposureindividuals who are pregnantinfant outcomeinnovateinnovationinnovativeinsightinsurance claimsintra-uterine environmental exposureintrauterine environmental exposureketosis resistant diabeteskidslower BPlower blood pressurelowers blood pressuremachine based learningmalformationmaternal outcomematurity onset diabetesmedication prescriptionmother outcomenovelpeople who are pregnantpharmacoepidemiologicpharmacoepidemiologicalpost-doctoral trainingpregnant femalespregnant motherspregnant peoplepregnant populationsprenatal exposureprenatally exposedprepregnancyprescribed medicationpreventpreventingreduce BPreduce blood pressurereduction in BPreduction in blood pressurereproductive agereproductive yearsresearch studyskeletalskillsstillbirthstillbornstudy designthose who are pregnanttreatment choicetype 2 DMtype II DMtype two diabetesunintended pregnancyweight loss interventionweight loss therapyweight loss treatmentweightswomen who are pregnantwt-lossyoungster
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Project Summary/Abstract
Given increases in recent decades to the prevalence of obesity among women of reproductive age and
to maternal ages, a substantial number of women are entering pregnancy with poor cardiometabolic health,
leading to adverse maternal and infant outcomes. While effective medications are available for both weight
loss and for…
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