grant
In situ bioprinting of high-density cell-laden core-shell microgel bioinks enabling cellular condensation for vascularized bone tissue regeneration
Organization JESSE BROWN VA MEDICAL CENTERLocation CHICAGO, UNITED STATESPosted 1 May 2024Deadline 30 Apr 2028
VANIHUS FederalResearch GrantFY20253-D3-D print3-D printer3-D structure3-Dimensional3-dimensional structure3D3D Print3D printer3D printing3D structureAddressAffectAir MovementsArchitectureArmed Forces PersonnelAutograftAutologous TransplantationAutotransplantBathingBathsBiocompatible MaterialsBiomaterialsBlood VesselsBody TissuesBone DensityBone InjuryBone Mineral DensityBone Morphogenetic Protein GeneBone Morphogenetic ProteinsBone RegenerationBone TissueCalvariaCell BodyCell CommunicationCell Culture TechniquesCell DensityCell DifferentiationCell Differentiation processCell InteractionCell-to-Cell InteractionCellsCephalicClinicalCommon Rat StrainsComplexCranialDefectDevelopmentDevicesEncapsulatedEngineeringEngineering / ArchitectureFaceFunctional RegenerationGelGeneralized GrowthGenerationsGeometryGrowthGrowth AgentsGrowth FactorGrowth SubstancesGunshot woundHealthHealth Care CostsHealth CostsHumanHydrogelsImmuneImmunesImplantIn SituIn VitroIndividualInflammatoryInjuryInvestigatorsLong-term painMechanicsMental HealthMental HygieneMesenchymal Progenitor CellMesenchymal Stem CellsMesenchymal progenitorMesenchymal stromal/stem cellsMethodsMilitaryMilitary PersonnelModern ManMorbidityMorbidity - disease rateNaturePainPainfulPatientsPatternPenetrationPersistent painPhenotypePhysical condensationPrintingProceduresProgenitor CellsProteins Growth FactorsPsychological HealthQOLQuality of lifeRatRats MammalsRattusReactionResearch PersonnelResearchersResolutionRoleShapesSiteSoldierStructureSystemTechniquesTechnologyTherapeuticTissue EngineeringTissue GrowthTissue constructsTissuesVEGFAVEGFA geneVascular Endothelial Growth Factor AVascularizationVasculogenicVasculotropinVeteransactive dutyactive serviceair flowairflowautologous graftautotransplantationbio-printingbioengineered tissuebioinkbiological materialbiomaterial scaffoldbioprintingbioscaffoldbonebone engineeringbone morphogenic proteincalvarialcell assemblycell culturecell culturescellular differentiationcombatcondensationconstant paincostcost estimatecost estimationcraniofacialcraniofacial bonecraniofaciescrosslinkdensitydesigndesigningdevelopmentaldisabilityendothelial progenitorendothelial progenitor cellendothelial stem cellengineered tissueexperiencefacesfacialgunshot injuryhealingimplantationimprovedin vivoinjuriesinjury of musculoskeletal system (disorder)injury of musculoskeleted systeminnovateinnovationinnovativelasting painmechanicmechanicalmesenchymal stromal cellmesenchymal stromal progenitor cellsmesenchymal-derived stem cellsmilitary populationmilitary veteranmusculoskeletal injurymusculoskeletal traumanew technologynovelnovel technologieson-going painongoing painontogenyosteogenicparticlephysical propertypre-clinicalpreclinicalregenerate boneregenerate new tissueregenerate tissueregenerating damaged tissueregenerating tissueresolutionsscaffoldscaffoldingself assemblysocial rolespatial and temporalspatial temporalspatiotemporalstandard carestandard treatmentstem cellsthree dimensionalthree dimensional printingthree dimensional structuretissue regenerationtissue regrowthtissue renewaltissue specific regenerationvascularveteran population
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Abstract
Bone damage and loss resulting from combat associated penetrating fragment projectiles, gunshot wounds and
improvised explosive devices are some of the most common injuries US Military personnel experience and
contribute to increasing Veterans’ health care costs. Yet, there are few viable options to consistently regenerate
functional…
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