grant
Improving the evaluation of high-risk deceased donor kidneys for transplantation
Organization WASHINGTON UNIVERSITYLocation SAINT LOUIS, UNITED STATESPosted 1 Apr 2026Deadline 28 Feb 2031
NIHUS FederalResearch GrantFY20263-D3-Dimensional3DAcuteAddressAgeAllograftingAnatomic SitesAnatomic structuresAnatomyAnimalsAtrophicAtrophyAutograftAutologous TransplantationAutotransplantBilateralBiological MarkersBiopsyBlood VesselsBody TissuesCessation of lifeChronic Kidney FailureChronic Renal DiseaseChronic Renal FailureClassificationClinicalClinical TrialsCollaborationsDataDeathDetectionEuthanasiaEvaluationFamily suidaeFerritinFibrosisFoundationsFutureGlomerular Filtration RateGoalsGraft SurvivalHealthHeterogeneityHistologicHistologicallyHistopathologyHumanImageImaging DeviceImaging InstrumentImaging ToolImmunochemical ImmunologicImmunologicImmunologicalImmunologicallyImmunologicsIndividualIschemia-Reperfusion InjuryKidneyKidney DiseasesKidney GraftingKidney TransplantationKidney TransplantsKidney Urinary SystemLabelLength of LifeLifeLocationLongevityMR ImagingMR TomographyMRIMRIsMachine LearningMagnetic Resonance ImagingMapsMeasurementMeasuresMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMercy KillingModelingModern ManMorphologyNMR ImagingNMR TomographyNephronsNephropathyNuclear Magnetic Resonance ImagingOrganOutcomePathologicPathologyPatientsPersonsPigsPopulationProtocolProtocols documentationRenal DiseaseRenal GraftingRenal TransplantationRenal TransplantsRenal functionReperfusion DamageReperfusion InjuryResearchResearch ResourcesResourcesSampling BiasesSclerosisSensitivity and SpecificitySiteSpecificitySuidaeSwineSystematicsTestingTissuesTitrationsTransplantationTubularTubular formationUriniferous TubeValidationVisualizationWorkZeugmatographyagesallotransplantallotransplantationautologous graftautotransplantationbio-markersbiologic markerbiomarkercandidate biomarkercandidate markercandidate validationchronic kidney diseaseclinical practicedeceased donordeceased organ donorsdensityevidence baseex vivo imagingglomerular sclerosisglomerulosclerosishealth assessmenthigh riskimage guidanceimage guidedimagingimaging biomarkerimaging markerimaging platformimaging-based biological markerimaging-based biomarkerimaging-based markerimprovedindexinginnovateinnovationinnovativeinterstitialischemia injuryischemic injurykidney allograftkidney disorderkidney functionkidney txmachine based learningnew approachesnovelnovel approachesnovel strategiesnovel strategyoutcome predictionpig modelpiglet modelporcineporcine modelposthumous donorsposthumous organ donorpotential biological markerpotential biomarkerprimary outcomerenalrenal allograftrenal arteryrenal disordersuidswine modelthree dimensionaltooltransplantusabilityvalidationsvascular
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PROJECT SUMMARY/ABSTRACT
Kidney allografts are a life-saving but limited resource. Nearly ~5000 deaths each year can be attributed to the
disproportionate number of patients who need an allograft compared to the number of available kidneys. The
majority of available kidneys are from deceased donors. Astonishingly, ~2500 procured kidneys are…
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