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Improving safety and access to immune effector cell therapy with artificial intelligence technology
Organization UNIVERSITY OF MINNESOTALocation MINNEAPOLIS, UNITED STATESPosted 1 Feb 2024Deadline 31 Jan 2026 ⚠️
NIHUS FederalResearch GrantFY2025AI AugmentedAI assistedAI basedAI botAI drivenAI enhancedAI integratedAI poweredAI systemAI technologyAccuracy of DiagnosisAdrenal Cortex HormonesAffectArtificial IntelligenceArtificial Intelligence enhancedAttentionAugmented by AIAugmented by the AIAugmented with AIAugmented with the AIBrain EdemaBrain SwellingCAR T cell therapyCAR T cellsCAR T therapyCAR modified T cellsCAR-TCAR-TsCancer PatientCancer TreatmentCaringCell TherapyCessation of lifeClassificationClinicalClinical PharmacologyClinical ProtocolsClinical ResearchClinical StudyClinical TrialsCognitiveCognitive DisturbanceCognitive ImpairmentCognitive ManifestationsCognitive SymptomsCognitive declineCognitive function abnormalComaComatoseComplicationComputer ReasoningConfusionConfusional StateCorticoidsCorticosteroidsDataDeathDetectionDisturbance in cognitionDoseDysgraphiasEarly DiagnosisEarly identificationEarly treatmentEffector CellEncephalopathiesExhibitsExpressive AphasiaFearFrightGenerationsGoalsHealth InformaticsHematologyHourHumanICANSIRBIRBsImmediate MemoryImmuneImmune MonitoringImmune mediated therapyImmunesImmunodiagnosesImmunodiagnosisImmunologic DiagnosisImmunologic MonitoringImmunological DiagnosisImmunological MonitoringImmunologically Directed TherapyImmunomonitoringImmunotherapeutic agentImmunotherapyImpaired cognitionIndividualInfusionInfusion proceduresInpatientsInstitutional Review BoardsIntracranial EdemaIntubationLanguageLearningMachine IntelligenceMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMeasurementMemoryMemory DeficitMemory impairmentMental ConfusionModalityModelingModern ManMonitorMotorNatural Language ProcessingNeurobehavioral ManifestationsNeurobehavioral Signs and SymptomsNeurocognitiveOutcomePatient MonitoringPatient SelectionPatientsPersonsPhonePositionPositioning AttributeProtocolProtocols documentationProviderPublic Health InformaticsRiskSafetySensitivity and SpecificitySeveritiesShort-Term MemorySpecificitySpeechSteroid CompoundSteroidsStimulusStressSymptomsSystematicsSystems AnalysesSystems AnalysisT cells for CARTechnologyTelephoneTestingTimeTransmissionWorkanti-cancer therapyartificial intelligence assistedartificial intelligence augmentedartificial intelligence basedartificial intelligence drivenartificial intelligence integratedartificial intelligence poweredartificial intelligence technologyassociated symptomautomated analysiscancer therapycancer-directed therapycell based interventioncell mediated interventioncell mediated therapiescell-based therapeuticcell-based therapycellular therapeuticcellular therapychat botchatbotchimeric antigen T cell receptorchimeric antigen receptor (CAR) T cell therapychimeric antigen receptor (CAR) T cellschimeric antigen receptor Tchimeric antigen receptor T cell therapychimeric antigen receptor T cellschimeric antigen receptor T therapychimeric antigen receptor fusion protein T-cellschimeric antigen receptor modified T cellsco-morbid symptomco-occuring symptomcognitive assessmentcognitive dysfunctioncognitive losscognitive testingcomorbid symptomcomputer human interactionconcurrent symptomconsumer informaticsconversational AIconversational agentconversational botcooccuring symptomcost effectivedebilitating symptomdesigndesigningdevelop softwaredeveloping computer softwarediagnostic accuracydiagnostic tooldysgraphiaearly detectionearly screeningearly therapyeffective therapyeffective treatmentenhanced with AIenhanced with Artificial Intelligenceimmune cell therapy associated neurologic toxicityimmune drugsimmune effector cell mediated neurotoxicity syndromeimmune effector cell-associated neurotoxicityimmune effector cell-associated neurotoxicity syndromeimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based therapeuticsimmune-based therapiesimmune-based treatmentsimmuno therapyimmunologic therapeuticsimmunotherapeuticsimmunotherapy agentimprovedinfusionsman-machine interactionmemory dysfunctionmultidisciplinarynatural language understandingneurobehavioral symptomneurocognitive testneuron toxicityneuronal toxicityneurotoxicitynew approachesnovel approachesnovel strategiesnovel strategypatient responsepatient specific responsepre-clinical studypreclinical studypreventpreventingprospectiverandom forestresponseresponsive patientrisk minimizationscreeningscreeningssoftware developmentstandard of caresymptom associationsymptom clustersymptom comorbiditytherapeutic outcometherapy outcometransmission processverbalwet brainworking memory
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Description preview
PROJECT SUMMARY
Immune effector cell-associated neurotoxicity syndrome (ICANS) is a cluster of symptoms associated with
immunotherapy that did not show up in pre-clinical studies but has been found in 40-90% of the people
undergoing immunotherapy as part of cancer treatment. The purpose of ICANS detection and prompt
treatment is to halt ICANS…
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