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Improving Husbandry and Data Reproducibility Through Automated Health Monitoring in Zebrafish Facilities

Organization NEMAMETRIX, INC.Location Eugene, UNITED STATESPosted 1 Aug 2023Deadline 30 Apr 2026 ⚠️
NIHUS FederalResearch GrantFY202521+ years oldAchievementAchievement AttainmentAdultAdult HumanAffectAgarAlgorithmic SoftwareAlgorithmic ToolsAlgorithmsAnimal ModelAnimal Models and Related StudiesAnimalsAquacultureAreaBehavioralBrachydanio rerioC elegansC. elegansC.elegansCaenorhabditis elegansConsumptionDanio rerioDataData AnalysesData AnalysisData BasesDatabasesDevelopmentDiseaseDisorderEcologic MonitoringEcological MonitoringEnsureEnvironmental MonitoringEthical IssuesFishesFundingGenesHealthHeightHourHumanImageImaging DeviceImaging InstrumentImaging ToolLaboratoriesLengthMiceMice MammalsModern ManMonitorMorphologyMovementMurineMusNematodaNematodesNutritionOrthologOrthologous GenePatternPhasePhenotypePopulationProviderReportingReproducibilityResearchRestSBIRScientistSiteSmall Business Innovation ResearchSmall Business Innovation Research GrantSoftware AlgorithmStandardizationSystemSystems AnalysesSystems AnalysisTemperatureTestingTherapeuticTimeUnited StatesVeterinariansVisualWorkZebra DanioZebra FishZebrafishadulthoodanimal imagingautomated algorithmautomatic algorithmbody movementcostcost effectivedata basedata interpretationdata managementdesigndesigningdevelop softwaredeveloping computer softwaredevelopmentaldrug developmentenhance healthspanenvironmental testingexperimentexperimental researchexperimental studyexperimentsextend healthspanextending healthy lifespanfeedingglobal healthhealthspan extensionhuman diseasehuman modelimage processingimagingimaging systemimprove healthspanimprovedincrease healthspaninsightlife spanlifespanmarine culturemodel of animalmodel of humanproduct developmentprolong healthspanpromote healthspanprototyperesponseroundwormscreeningscreeningssoftware developmenttoolwastingwater quality

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ABSTRACT / SUMMARY
The zebrafish is an invaluable tool for developing and screening human therapeutics and modeling human
diseases. This animal model is strikingly genetically similar to humans, sharing 70% of all human genes (by
comparison, mice have orthologs of ~80% of human genes), and 82-90% of human disease-associated genes.
Currently,…

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