grant
Improving health among disadvantaged girls to slow pubertal onset and reduce long-term health risks
Organization UNIVERSITY OF WASHINGTONLocation SEATTLE, UNITED STATESPosted 1 Jul 2025Deadline 30 Jun 2030
NIHUS FederalResearch GrantFY20250-11 years oldAccelerationActive Follow-upAddressAdult-Onset Diabetes MellitusAgeAlcohol DrinkingAlcohol consumptionAnimalsAreaBMIBMI percentileBMI z-scoreBehavior Conditioning TherapyBehavior ModificationBehavior TherapyBehavior TreatmentBehavior assessmentBehavioral Conditioning TherapyBehavioral ModificationBehavioral TherapyBehavioral TreatmentBlood PressureBody ImageBody Weight decreasedBody mass indexBreastCancersCardiovascular DiseasesChildChild YouthChildhoodChildren (0-21)ClinicalConditioning TherapyControl GroupsDHA SulfateDHEA SulfateDehydroepiandrosterone SulfateDehydroisoandrosterone SulfateDeliberate Self-HarmDevelopmentDietDietary qualityDisadvantagedDiseaseDisorderDrug usageEatingEating DisordersEconomic IncomeEconomical IncomeEconomicsEffectivenessEligibilityEligibility DeterminationEmotionalEndocrine Gland SecretionEntire hair of pubisEtOH drinkingEtOH useEthnic OriginEthnicityFamilyFood IntakeFrequenciesHealthHealth StatusHealth behaviorHealth behavior changeHormonesHouseholdHousingIGF-1IGF-IIGF-I-SmCImpoverishedIncomeInflammationInsulin ResistanceInsulin-Like Growth Factor 1Insulin-Like Growth Factor IInsulin-Like Somatomedin Peptide IIntakeInterstitial Cell Stimulating HormoneInterstitial Cell-Stimulating HormoneInterventionKetosis-Resistant Diabetes MellitusKnowledgeLeptinLeuteinizing HormoneLevel of HealthLifeLife CycleLife Cycle StagesLinkLuteinizing HormoneLutropinMalignant NeoplasmsMalignant TumorMaturity-Onset Diabetes MellitusMeasuresMediatingMenarcheMental DepressionMetabolic hormoneMethodsNIDDMNon-Insulin Dependent DiabetesNon-Insulin-Dependent Diabetes MellitusNoninsulin Dependent DiabetesNoninsulin Dependent Diabetes MellitusNutritionalOb Gene ProductOb ProteinObese Gene ProductObese ProteinObesityOutcomeOver weightOverweightPathway interactionsPatient Self-ReportPerformancePhysical activityPituitary Lutenizing HormonePovertyPrasterone SulfatePrepuberal stateProcessProteinsProtocol ScreeningPubertyPubic HairQuestionnairesQuetelet indexRaceRacesRecombinant Luteinizing HormoneReportingResearchRiskRisk FactorsSchoolsSelf-Injurious BehaviorSelf-ReportSleepSlow-Onset Diabetes MellitusSocioeconomically disadvantagedSomatomedin CStable Diabetes MellitusStagingT2 DMT2DT2DMTeenTeenagersTherapeutic HormoneTherapeutic LHTimeType 2 Diabetes MellitusType 2 diabetesType II Diabetes MellitusType II diabetesWeightWeight GainWeight IncreaseWeight LossWeight ReductionWeight maintenance regimenWorkactive followupadiposityadult onset diabetesadverse childhood eventsadverse childhood experiencesagesalcohol ingestionalcohol intakealcohol product usealcohol usealcoholic beverage consumptionalcoholic drink intakebehavior interventionbehavioral assessmentbehavioral interventionbody perceptionbody weight gainbody weight increasebody weight losscardiometaboliccardiometabolic riskcardiometabolismcardiovascular disorderchild adipositychild obesitychildhood adipositychildhood obesitycorpulencecostdeliberate self harmdepressiondevelopmentaldiet qualitydietsdrug useearly experienceeconomicethanol consumptionethanol drinkingethanol ingestionethanol intakeethanol product useethanol useevidence baseexperiencefamily supportfollow upfollow up assessmentfollow-upfollowed upfollowupfollowup assessmentgirlshealth levelhealth related behaviorimprovedincomesindexinginitiation of sexual activityinsulin resistantinsulin toleranceintentional self harmintentional self injuryketosis resistant diabeteskidsknowledge baselife courselower income familiesmalignancymalleable riskmaturity onset diabetesmodifiable riskmortalitymotherhoodneoplasm/cancernovelnutritiousobese childrenobesity during childhoodobesity in childrenobesity interventionobesity preventionobesity therapyobesity treatmentpathwaypediatricpediatric obesitypeerphysical conditioningphysical healthprepubertalprepubertyprevent obesityprospectivepubertal timingracialracial backgroundracial originself esteemself harmself injurysexual debutsexual initiationsleep amountsleep durationsleep episodesleep intervalsleep lengthsleep periodsleep quantitysleep timesocialsocio-economic disadvantagesocio-economically disadvantagedsocio-economically underprivilegedsocioeconomic disadvantagesocioeconomically underprivilegedteen yearsteenagetime asleeptime during sleeptime in sleeptime spent asleeptime spent sleepingtreatment programtype 2 DMtype II DMtype two diabetesweight controlweight loss interventionweight loss therapyweight loss treatmentweight managementweightswt gainwt-lossyoungster
Description preview
Girls who experience puberty earlier than their same-age peers are at disproportionate risk for poor outcomes
across domains of emotional, social, and physical health, setting the stage for life-long hardships. Just some of
these outcomes include depression, self-harm, low self-esteem, poor body image, disordered eating, poor school
performance,…
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