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Implications of gastrointestinal motility and diet on irritable bowel syndrome associated symptoms
Organization CHILDREN'S HOSP OF PHILADELPHIALocation PHILADELPHIA, UNITED STATESPosted 1 Feb 2025Deadline 30 Apr 2025 ⚠️
NIHUS FederalResearch GrantFY20250-11 years old21+ years old4-O-beta-D-galactopyranosyl-D-glucoseAbdominal PainAddressAdherenceAdultAdult HumanAffectAnxietyAutomobile DrivingC syndromeCaringCell Communication and SignalingCell SignalingCharacteristicsChildChild YouthChildren (0-21)ColonComplexConstipationCountryDataDefecationDevelopmentDevicesDiagnosisDiagnostic MethodDiagnostic ProcedureDiagnostic TechniqueDiarrheaDietDietary InterventionDietary intakeDisaccharidesDiseaseDisorderDysfunctionEatingFailureFoodFood AdditivesFood IntakeFoundationsFunctional disorderFutureGI microbiotaGastrointestinal MotilityGastrointestinal TransitGastrointestinal microbiotaGoalsHealthHourHypersensitivityIatrogenesisImpairmentIndividualIngestionIntakeIntestinalIntestinesIntracellular Communication and SignalingIrritable Bowel SyndromeIrritable ColonJointsKnowledgeLactoseLifeLinkLocomotor ActivityLongitudinal observation studyLongitudinal, observational studyManometryManometry BiochemistryMeasuresMedicalMonosaccharidesMotilityMotor ActivityMucous ColitisNerveNutritionNutrition InterventionsNutritional InterventionsNutritional statusOligosaccharidesOpitz trigonocephaly syndromeOrganPathway interactionsPatientsPatternPersonalized medical approachPhenotypePhysiopathologyPlayPopulationPsychosocial StressQOLQuality of lifeReference RangesReference ValuesReportingRiskRoleSeveritiesSignal TransductionSignal Transduction SystemsSignalingSmall IntestinesSocial DevelopmentStomachStressSymptomsSystemTechniquesTestingTimeVisceralWait TimeWheatadulthoodalleviate symptomameliorating symptomassociated symptombiological signal transductionbowelbowel movementco-morbid symptomco-occuring symptomcomorbid symptomcompare to controlcomparison controlconcurrent symptomcooccuring symptomcostcustomized therapycustomized treatmentdecrease symptomdevelopmentaldiagnostic tooldiet interventiondietarydietsdisorders of gut-brain interactiondrivingeggenteric microbial communityenteric microbiotafeedingfewer symptomsgastricgastrointestinalgastrointestinal microbial floragastrointestinal symptomgut communitygut floragut microbe communitygut microbial communitygut microbial compositiongut microbial consortiagut microbiotagut microbioticgut microflorahealth dataiatrogeniciatrogenicallyiatrogenicityimprove symptomimprovedindividualized approachindividualized medicineindividualized patient treatmentindividualized therapeutic strategyindividualized therapyindividualized treatmentingestinnovateinnovationinnovativeintestinal floraintestinal microbiotaintestinal microfloraintestinal tract microflorakidsmicrobialnon-invasive diagnosisnon-invasive diagnosticnoninvasive diagnosisnoninvasive diagnosticnovelpain reliefpain sensationpainful sensationpathophysiologypathwaypatient specific therapiespatient specific treatmentpersonalization of treatmentpersonalized approachpersonalized medicinepersonalized therapypersonalized treatmentpharmacologicpolyolprecision approachprospectivepsychosocialreduce symptomsrelieve painrelieves symptomssmall bowelsocial rolespastic colonsymptom alleviationsymptom associationsymptom comorbiditysymptom improvementsymptom reductionsymptom reliefsymptomatic improvementtailored approachtailored medical treatmenttailored therapytailored treatmenttherapeutic targettime usetooltrigonocephaly syndromeunique treatmentwirelessyoungster
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PROJECT SUMMARY
Irritable bowel syndrome (IBS) is a disorder of gut-brain interaction affecting about 11% of the global population
and ~ 10-20% of adults in Western countries, and highly prevalent in children, impairing social development and
quality of life (QoL). Abdominal pain, bloating, constipation and/or diarrhea are characteristic symptoms…
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